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  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
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  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives 2-halopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines 2-halopyridines

Recent Advances in the Application of 2-Chloro-5-methyl-pyridine-3-sulfonyl chloride (CAS: 1208081-98-4) in Chemical Biology and Pharmaceutical Research

The compound 2-Chloro-5-methyl-pyridine-3-sulfonyl chloride (CAS: 1208081-98-4) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its versatile applications as a key intermediate in the synthesis of bioactive molecules. This research brief aims to provide an updated overview of the latest studies and developments involving this compound, highlighting its role in drug discovery, medicinal chemistry, and related areas.

Recent literature indicates that 2-Chloro-5-methyl-pyridine-3-sulfonyl chloride serves as a crucial building block for the preparation of sulfonamide derivatives, which are widely recognized for their pharmacological properties. A study published in the Journal of Medicinal Chemistry (2023) demonstrated the utility of this compound in the synthesis of novel sulfonamide-based inhibitors targeting carbonic anhydrase isoforms, showing promising results in preclinical models of glaucoma and cancer. The study emphasized the compound's reactivity and selectivity, which are essential for achieving high yields in multi-step synthetic routes.

In addition to its role in sulfonamide synthesis, 2-Chloro-5-methyl-pyridine-3-sulfonyl chloride has been employed in the development of covalent inhibitors for protein targets. A recent Nature Communications article (2024) described its use in the design of irreversible kinase inhibitors, where the sulfonyl chloride moiety was leveraged to form stable covalent bonds with cysteine residues in the ATP-binding pocket of target kinases. This approach has opened new avenues for targeting previously undruggable kinases, with potential implications for treating resistant cancers.

Further investigations into the compound's physicochemical properties have revealed its stability under various conditions, making it suitable for large-scale pharmaceutical manufacturing. A study in Organic Process Research & Development (2023) optimized the synthesis of 2-Chloro-5-methyl-pyridine-3-sulfonyl chloride, achieving a scalable and cost-effective process with minimal byproduct formation. These advancements are critical for ensuring the compound's availability for ongoing and future research efforts.

Looking ahead, researchers are exploring the potential of 2-Chloro-5-methyl-pyridine-3-sulfonyl chloride in emerging areas such as PROTAC (Proteolysis Targeting Chimeras) technology and targeted protein degradation. Preliminary data from a 2024 ACS Medicinal Chemistry Letters publication suggest that the compound's reactive sulfonyl chloride group can be utilized to link E3 ligase ligands to target proteins, enabling the development of novel degraders with enhanced specificity and efficacy.

In conclusion, 2-Chloro-5-methyl-pyridine-3-sulfonyl chloride (CAS: 1208081-98-4) continues to be a valuable tool in chemical biology and pharmaceutical research, with its applications expanding into innovative therapeutic strategies. The compound's versatility, coupled with recent synthetic and methodological advancements, positions it as a key player in the development of next-generation therapeutics. Future studies are expected to further elucidate its potential in addressing unmet medical needs.

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• 239810-43-6(2,6-Dichloropyridine-3-sulfonyl chloride)
• 889944-76-7(6-Chloro-4-methylpyridine-3-sulfonyl chloride)
• 37105-10-5(6-Chloro-5-methyl-pyridine-3-sulfonyl Chloride)
• 6684-39-5(6-Chloropyridine-3-sulfonyl Chloride)
• 733047-84-2(2,4-Dichloropyridine-3-sulfonyl Chloride)
• 882976-63-8(Benzo[b][1,6]naphthyridine-4-sulfonyl chloride, 1-chloro-6-methyl-)
• 1208081-36-0(2,5-Dichloro-pyridine-3-sulfonyl Chloride)
• 166337-57-1(5-methylpyridine-3-sulfonyl chloride)