Cas no 1204333-58-3 (2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine)

2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a boronic ester derivative of pyridine, characterized by its difluoro substitution at the 2- and 6-positions and a pinacol boronate group at the 4-position. This compound serves as a versatile intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the synthesis of complex biaryl structures. The electron-withdrawing fluorine substituents enhance its reactivity in palladium-catalyzed transformations, while the pinacol boronate group ensures stability and ease of handling. Its well-defined structure and high purity make it suitable for pharmaceutical and agrochemical applications, particularly in the development of fluorinated heterocycles. The compound is typically supplied as a crystalline solid with consistent batch-to-batch reproducibility.
2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine structure
1204333-58-3 structure
Product Name:2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No:1204333-58-3
MF:C11H14BF2NO2
MW:241.04217004776
MDL:MFCD12913987
CID:839929
PubChem ID:46739811
Update Time:2025-08-03

2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Chemical and Physical Properties

Names and Identifiers

    • 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
    • (2,6-Difluoro-4-pyridyl)-(2-hydroxy-1,1,2-trimethyl-propoxy)borinic acid
    • 2,6-Difluoropyridine-4-boronic acid, pinacol ester
    • Pyridine, 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
    • 2,5-DIFLUOROBENZYL CHLORIDE
    • QC-7112
    • 2,6-Difluoro-pyridine-4-boronic acid pinacol ester
    • SCHEMBL2370008
    • (2,6-DIFLUOROPYRIDIN-4-YL)BORONIC ACID PINACOL ESTER
    • AS-55661
    • DB-292333
    • DTXSID60675394
    • MFCD12913987
    • AKOS016011117
    • Z2044805577
    • FUGGRIAHIVRPNM-UHFFFAOYSA-N
    • CS-0038557
    • 2,6-DIFLUORO-4-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
    • 2,6-DIFLUOROPYRIDINE-4-BORONIC ACID PINACOL ESTER
    • EN300-6253605
    • 1204333-58-3
    • MB12072
    • MDL： MFCD12913987
    • Inchi： 1S/C11H14BF2NO2/c1-10(2)11(3,4)17-12(16-10)7-5-8(13)15-9(14)6-7/h5-6H,1-4H3
    • InChI Key： FUGGRIAHIVRPNM-UHFFFAOYSA-N
    • SMILES： FC1C=C(B2OC(C)(C)C(C)(C)O2)C=C(N=1)F

Computed Properties

  • Exact Mass: 241.10900
  • Monoisotopic Mass: 241.109
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 17
  • Rotatable Bond Count: 1
  • Complexity: 275
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 31.4A^2

Experimental Properties

  • Density: 1.205
  • Boiling Point: 363.89 °C at 760 mmHg
  • Flash Point: 173.875 °C
  • PSA: 31.35000
  • LogP: 1.65900

2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Customs Data

  • HS CODE：2934999090
  • Customs Data：

    China Customs Code:

    2934999090

    Overview:

    2934999090. Other heterocyclic compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Alichem
A029193726-5g
2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
 1204333-58-3 95%
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 $2629.08 2023-09-04
Alichem
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 1204333-58-3 95%
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Chemenu
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SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.
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SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.
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2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
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SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.
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TRC
D447513-250mg
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TRC
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2,6-Difluoropyridine-4-boronic acid, pinacol ester
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TRC
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2,6-Difluoropyridine-4-boronic acid, pinacol ester
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2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Production Method

2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Related Literature

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