• 1. Conjugation-extended viologens with thiophene derivative bridges: near-infrared electrochromism, electrofluorochromism, and smart window applications
  Meijuan Chang,Weinan Chen,Haodong Xue,Dingli Liang,Xuefeng Lu,Gang Zhou J. Mater. Chem. C 2020 8 16129
• 2. Multi-pyridine decorated Fe(ii) and Ru(ii) complexes by Pd(0)-catalysed cross couplings: new building blocks for metallosupramolecular assemblies
  Jiajia Yang,Jack K. Clegg,Qibai Jiang,Xiaoming Lui,Hong Yan,Wei Zhong,Jonathon E. Beves Dalton Trans. 2013 42 15625
• 3. A new 18F-heteroaryltrifluoroborate radio-prosthetic with greatly enhanced stability that is labelled by 18F–19F-isotope exchange in good yield at high specific activity
  Z. Liu,N. Hundal-Jabal,M. Wong,D. Yapp,K.-S. Lin,F. Bénard,D. M. Perrin Med. Chem. Commun. 2014 5 171
• 4. A heterofunctional ligand approach for the preparation of high connectivity coordination polymers: combining a “bridge” and “pillar” in one ligand
  Hydar A. AL-Fayaad,Kasun S. Athukorala Arachchige,Jack K. Clegg CrystEngComm 2020 22 5310
• 5. Temperature-controlled sequential Suzuki–Miyaura reactions for preparing unsymmetrical terphenyls
  Xinmin Li,Chun Liu,Lei Wang,Qing Ye,Xin Jin,Zilin Jin Org. Biomol. Chem. 2018 16 8719

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives
• Other Chemical Reagents Derivatization Reagents
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Comprehensive Overview of 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS No. 181219-01-2)

4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS No. 181219-01-2) is a highly versatile boronic ester derivative widely utilized in organic synthesis, pharmaceutical research, and material science. This compound, characterized by its pyridine ring and dioxaborolane moiety, has garnered significant attention due to its unique reactivity and applications in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern drug discovery and agrochemical development.

In recent years, the demand for boron-containing compounds like 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine has surged, driven by advancements in catalytic chemistry and the growing need for high-performance materials. Researchers and industries are particularly interested in its role as a building block for heterocyclic frameworks, which are critical in designing biologically active molecules. Its stability under ambient conditions and compatibility with diverse reaction conditions make it a preferred choice for small-molecule synthesis.

One of the most searched questions related to this compound is: "How is 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine used in drug development?" The answer lies in its ability to facilitate C-C bond formation, enabling the construction of complex pharmaceutical intermediates. For instance, it is employed in the synthesis of kinase inhibitors and antiviral agents, aligning with the current focus on targeted therapies and personalized medicine.

Another trending topic is the compound's utility in material science, especially in the development of organic electronic devices. Its electron-deficient pyridine ring and boron-based functional group contribute to tunable optoelectronic properties, making it valuable for OLEDs and sensors. This aligns with the global push toward sustainable technologies and green chemistry.

From a synthetic perspective, 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine offers advantages such as ease of handling and compatibility with aqueous conditions, addressing common challenges in large-scale production. Its CAS No. 181219-01-2 is frequently referenced in patents and academic publications, underscoring its industrial relevance. For researchers exploring boron chemistry, this compound serves as a gateway to innovative catalytic systems and functional materials.

In summary, 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS No. 181219-01-2) is a pivotal chemical entity bridging multiple disciplines. Its applications in drug discovery, material engineering, and catalysis reflect its adaptability to evolving scientific and industrial needs. As interest in boron-based compounds continues to rise, this compound remains at the forefront of cutting-edge research.

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