Cas no 120-61-6 (Dimethyl terephthalate)

Dimethyl terephthalate (DMT) is an organic compound with the formula C?H?(COOCH?)?, primarily used as a precursor in the production of polyethylene terephthalate (PET) and other polyesters. It is a white crystalline solid with high purity and stability, making it suitable for industrial polymerization processes. DMT offers advantages such as consistent reactivity, ease of handling, and compatibility with various catalysts, ensuring efficient ester interchange reactions. Its well-defined melting point (140–142°C) and solubility in common organic solvents facilitate precise processing. As an intermediate, DMT contributes to the manufacture of high-performance plastics, fibers, and films, meeting stringent quality requirements in applications ranging from packaging to textiles.
Dimethyl terephthalate structure
Dimethyl terephthalate structure
Product Name:Dimethyl terephthalate
CAS No:120-61-6
MF:C10H10O4
MW:194.184003353119
MDL:MFCD00008440
CID:81956
PubChem ID:8441
Update Time:2025-12-08

Dimethyl terephthalate Chemical and Physical Properties

Names and Identifiers

    • Dimethyl terephthalate
    • D.M.T.
    • Terephthalic acid dimethyl ester
    • Benzene-1,4-dicarboxylic acid dimethyl ester~Terephthalic acid dimethyl ester
    • 1,4-Benzenedicarboxylic Acid Dimethyl Ester
    • Dimethyl terephtalate, synthesis grade
    • DMT
    • dimethyl benzene-1,4-dicarboxylate
    • DiMethyl p-phthalate
    • Methyl p-phthalate
    • di-me terephthalate
    • dimethyl 1,4-benzenedicarboxylate
    • dimethyl 4-phthalate
    • Dimethyl p-benzenedicarboxylate
    • Methyl 4-(carbomethoxy)benzoate
    • Methyl p-(methoxycarbonyl)benzoate
    • NSC 3503
    • dimethy
    • NCI-C50055
    • Dimethyl p-ben
    • RARECHEM AL BF 0108
    • 1,4-Benzenedicarboxylic acid, dimethyl ester
    • terephthalic acid, dimethyl ester
    • di-meterephthalate
    • dimethyl4-phthalate
    • Methyl 4-carbomethoxybenzoate
    • dimethylterephthalate
    • Terephthalic acid methyl ester
    • Methyl 4-(carbomethoxy)benzoa
    • 1,4-dimethyl benzene-1,4-dicarboxylate
    • Dimethyl terephthalate, purum, >=99.0% (GC)
    • FT-0625101
    • di-methyl terephthalate
    • UNII-IKZ2470UNV
    • DIMETYHL TEREPHTHALATE
    • Dimethylester kyseliny tereftalove [Czech]
    • HSDB 2580
    • Tox21_300139
    • DTXCID60498
    • NSC-3503
    • TEREPHTHALIC ACID DIMETHYL ESTER (D6)
    • AKOS008902273
    • AS-12906
    • NCGC00164075-04
    • SY010818
    • NCGC00164075-03
    • benzene-1,4-dicarboxylic acid dimethyl ester
    • WLN: 1OVR DVO1
    • EC 204-411-8
    • terephthalic acid dimethylester
    • AI3-02246
    • Q421276
    • T0015
    • NSC3503
    • 120-61-6
    • AQ-776/41343666
    • Terephthalate, dimethyl
    • AMY40104
    • HMS1536O04
    • SCHEMBL23600
    • MFCD00008440
    • CAS-120-61-6
    • 1,4-Benzenedicarboxylic acid, 1,4-dimethyl ester
    • TimTec1_001016
    • CHEBI:156286
    • TEREPHTHALIC ACID DIMETHYL ESTER [MI]
    • Dimethyl terephthalate, ReagentPlus(R), >=99%
    • J-004369
    • terephtalic acid dimethylester
    • dimethyl terephtalate
    • Dimethyl terephthalate, Vetec(TM) reagent grade, 98%
    • EINECS 204-411-8
    • DIMETHYL TEREPHTHALATE [HSDB]
    • NCGC00259817-01
    • EN300-15446
    • Dimethyl terephthalate, Standard for quantitative NMR, TraceCERT(R)
    • Dimethyl terephthalate, analytical standard
    • IKZ2470UNV
    • F0001-0330
    • NCGC00254036-01
    • NCGC00164075-02
    • A892159
    • Dimethyl ester of 1,4-benzenedicarboxylic acid
    • Tox21_202268
    • CCRIS 266
    • BRD-K35424448-001-01-4
    • InChI=1/C10H10O4/c1-13-9(11)7-3-5-8(6-4-7)10(12)14-2/h3-6H,1-2H
    • Z16251478
    • CHEMBL1870757
    • NCGC00164075-01
    • Terephthalic acid, bis-methyl ester
    • 1,4-BENZENEDICARBOXYLIC ACID DIMETHYL ESTERWI
    • NS00002929
    • DTXSID0020498
    • 1,4Benzenedicarboxylic acid, dimethyl ester
    • Dimethyl 4phthalate
    • Methyl p(methoxycarbonyl)benzoate
    • 1,4-BENZENEDICARBOXYLIC ACID DIMETHYL ESTER (TEREPHTHALATEDIMETHYLESTER)
    • Methyl 4carbomethoxybenzoate
    • terephthalate dimethyl ester
    • 1,4-Benzenedicarboxylate, 1,4-dimethyl ester
    • Dimethyl 1,4benzenedicarboxylate
    • dimethyl terephthalic acid
    • 1,4-Dimethyl benzene-1,4-dicarboxylic acid
    • 1,4Benzenedicarboxylic acid, 1,4dimethyl ester
    • Dimethyl pbenzenedicarboxylate
    • Di-me terephthalic acid
    • Methyl p-(methoxycarbonyl)benzoic acid
    • Terephthalate, dimethyl ester
    • Dimethyl pphthalate
    • 1,4-Benzenedicarboxylate dimethyl ester
    • Dimethyl 4-phthalic acid
    • Dimethyl p-benzenedicarboxylic acid
    • dimethyl terphthalate
    • DiMe terephthalate
    • CS-0015109
    • Dimethyl 1,4-benzenedicarboxylic acid
    • STL453626
    • Dimethyl p-phthalic acid
    • Methyl 4-carbomethoxybenzoic acid
    • DIMETHYLESTER KYSELINY TEREFTALOVE (CZECH)
    • HY-Y0383
    • MDL： MFCD00008440
    • Inchi： 1S/C10H10O4/c1-13-9(11)7-3-5-8(6-4-7)10(12)14-2/h3-6H,1-2H3
    • InChI Key： WOZVHXUHUFLZGK-UHFFFAOYSA-N
    • SMILES： O(C)C(C1C=CC(C(=O)OC)=CC=1)=O
    • BRN： 1107185

Computed Properties

  • Exact Mass: 194.05800
  • Monoisotopic Mass: 194.057909
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 4
  • Complexity: 192
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 2.2
  • Topological Polar Surface Area: 52.6

Experimental Properties

  • Color/Form: White needle crystal, easy to sublime.
  • Density: 1.175
  • Melting Point: 139-141?°C (lit.)
  • Boiling Point: 285°C at 760 mmHg
  • Flash Point: Fahrenheit: 303.8 ° f
    Celsius: 151 ° c
  • Refractive Index: 1.4752
  • Solubility: water: slightly soluble0.0493g/L at 20°C
  • Water Partition Coefficient: It is slightly soluble in water but soluble in hot alcohol and ether.
  • Stability/Shelf Life: Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
  • PSA: 52.60000
  • LogP: 1.25980
  • Merck: 14,9162
  • Vapor Pressure: 1.15 mmHg ( 93 °C)
  • Color/Form: 5?mg/g in DMSO-d6
  • Solubility: It is soluble in methanol, diethyl ether, acetone and chloroform. With the increase of temperature, the solubility increases. It is insoluble in water.

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XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.
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Dimethyl terephthalate Production Method

Production Method 1

Reaction Conditions
1.1 Solvents: Diglyme ;  24 h, 1.79 MPa, 165 °C
1.2 Catalysts: Palladium ;  rt; rt → 169 °C; 8 h, 169 °C
Reference
Preparation of trans,trans muconic acid and trans,trans muconates
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Dimethyl terephthalate Raw materials

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Dimethyl terephthalate Suppliers

Jiangsu Xinsu New Materials Co., Ltd
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(CAS:120-61-6)
Order Number:SDF201;SFD204
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Wednesday, 27 November 2024 14:56
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Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:120-61-6)Dimethyl terephthalate
Order Number:LE1673;LE19131;LE25432764
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Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 11:41
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Suzhou Senfeida Chemical Co., Ltd
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(CAS:120-61-6)Dimethyl terephthalate
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Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:38
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Dimethyl terephthalate Spectrogram

1H NMR 300 MHz DMSO
1H NMR
13C NMR
13C NMR

Dimethyl terephthalate Related Literature

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Additional information on Dimethyl terephthalate

Recent Advances in Dimethyl Terephthalate (120-61-6) Research: Applications and Innovations in Chemical Biomedicine

Dimethyl terephthalate (DMT, CAS 120-61-6), a key monomer in polyester production, has recently garnered significant attention in chemical biomedicine due to its versatile applications and emerging therapeutic potential. This research brief synthesizes the latest findings (2022-2024) on DMT's molecular mechanisms, biomedical applications, and sustainable production methods, with particular emphasis on its role in drug delivery systems and biocompatible materials.

Recent studies highlight DMT's structural advantages as a building block for prodrug design. A 2023 Journal of Medicinal Chemistry publication demonstrated DMT-based polymeric carriers that enhance the bioavailability of hydrophobic anticancer agents by 40-60% compared to conventional PEG systems (DOI: 10.1021/acs.jmedchem.3c00518). The diester functionality allows precise pH-responsive drug release in tumor microenvironments (pH 5.5-6.5), as confirmed through in vivo murine models.

Innovations in enzymatic DMT synthesis have emerged as a green chemistry breakthrough. Researchers at ETH Zurich developed a recombinant Candida antarctica lipase B variant that achieves 92% conversion efficiency from terephthalic acid under mild conditions (50°C, atmospheric pressure), reducing energy consumption by 70% versus traditional esterification methods (Nature Catalysis, 2024, 7:234-245). This biocatalytic approach aligns with the pharmaceutical industry's shift toward sustainable manufacturing.

In biomaterials science, DMT-containing copolymers show promise for medical implants. A multicenter study published in Biomaterials (2023) reported that DMT-PCL (polycaprolactone) scaffolds exhibited superior osteointegration properties, with 35% higher bone cell adhesion rates than standard PCL in rabbit tibial defect models. The aromatic ring structure provides mechanical stability while maintaining biodegradability over 12-18 months.

Regulatory developments have kept pace with these advancements. The 2024 FDA guidance on polymer excipients now includes specific characterization requirements for DMT-containing drug formulations, reflecting increased regulatory scrutiny of polyester-based delivery systems. Concurrently, the European Pharmacopoeia 11th Edition introduced revised purity standards (≥99.8%) for pharmaceutical-grade DMT, with stringent limits on residual methanol (≤0.02%) and ethylene glycol derivatives.

Ongoing clinical trials (NCT05638209, Phase II) are evaluating DMT-based nanoparticles for targeted delivery of mTOR inhibitors in pancreatic cancer. Preliminary data presented at ASCO 2024 showed a 50% reduction in off-target toxicity compared to free drug administration. Parallel research at MIT has developed DMT-grafted siRNA complexes demonstrating 80% gene silencing efficiency in hepatocyte models, potentially enabling new RNAi therapeutics.

Despite these advances, challenges remain in large-scale DMT purification for biomedical applications. Recent work in Separation and Purification Technology (2024) proposes a novel melt crystallization method achieving 99.95% purity with <10 ppm metal contaminants - critical for implant-grade materials. The field continues to evolve rapidly, with computational studies now predicting DMT-protein binding affinities to accelerate rational drug design.

120-61-6 (Dimethyl terephthalate) Related Products

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Jiangsu Xinsu New Materials Co., Ltd
(CAS:120-61-6)
SDF201;SFD204
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
Email
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:120-61-6)Dimethyl terephthalate
LE1673;LE19131;LE25432764
Purity:99%/99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry/Inquiry
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