• 1. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 2. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridine carboxaldehydes

Introduction to 4-Bromo-5-methyl-2-pyridinecarbaldehyde (CAS No. 1196157-14-8)

4-Bromo-5-methyl-2-pyridinecarbaldehyde, with the CAS number 1196157-14-8, is a versatile compound that has garnered significant attention in the fields of medicinal chemistry and organic synthesis. This compound is characterized by its unique structure, which includes a bromo substituent at the 4-position, a methyl group at the 5-position, and an aldehyde functional group at the 2-position of the pyridine ring. The combination of these functional groups endows 4-Bromo-5-methyl-2-pyridinecarbaldehyde with a range of chemical properties that make it a valuable intermediate in the synthesis of various bioactive molecules.

The pyridine ring is a fundamental building block in many pharmaceuticals and agrochemicals due to its aromatic nature and ability to form stable complexes with metal ions. The presence of the bromo substituent in 4-Bromo-5-methyl-2-pyridinecarbaldehyde provides a reactive handle for further chemical modifications, such as cross-coupling reactions, which are crucial for the synthesis of complex organic molecules. Additionally, the aldehyde group offers opportunities for condensation reactions, making this compound a key starting material in the development of novel drugs and materials.

Recent research has highlighted the potential applications of 4-Bromo-5-methyl-2-pyridinecarbaldehyde in various areas. For instance, studies have shown that compounds derived from this structure exhibit potent biological activities, including anti-inflammatory, antimicrobial, and anticancer properties. One notable example is its use as an intermediate in the synthesis of pyridyl-containing antitumor agents. These agents have shown promising results in preclinical studies, demonstrating their ability to inhibit cancer cell proliferation and induce apoptosis.

In addition to its pharmaceutical applications, 4-Bromo-5-methyl-2-pyridinecarbaldehyde has also been explored for its potential in materials science. The unique electronic properties of pyridine derivatives make them suitable for use in organic electronics and photovoltaic devices. Researchers have utilized this compound to synthesize conjugated polymers with enhanced charge transport properties, which are essential for improving the performance of organic solar cells and other electronic devices.

The synthetic accessibility of 4-Bromo-5-methyl-2-pyridinecarbaldehyde has been well-documented in the literature. Several efficient synthetic routes have been developed to produce this compound on both laboratory and industrial scales. One common approach involves the bromination of 5-methylpyridine followed by oxidation to introduce the aldehyde functionality. These methods are highly reproducible and scalable, making 4-Bromo-5-methyl-2-pyridinecarbaldehyde readily available for further research and development.

The stability and reactivity of 4-Bromo-5-methyl-2-pyridinecarbaldehyde have also been extensively studied. This compound is generally stable under standard laboratory conditions but can undergo various chemical transformations when exposed to specific reagents or conditions. For example, it can readily undergo nucleophilic addition reactions at the aldehyde carbon, forming new C-N or C-O bonds. These reactions are often used to introduce additional functional groups or to form more complex molecular architectures.

In summary, 4-Bromo-5-methyl-2-pyridinecarbaldehyde (CAS No. 1196157-14-8) is a multifaceted compound with significant potential in both pharmaceutical and materials science applications. Its unique structural features and synthetic versatility make it an invaluable tool for researchers and chemists working on the development of new bioactive molecules and advanced materials. As ongoing research continues to uncover new applications and properties of this compound, its importance in the scientific community is likely to grow even further.

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