• 1. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 2. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
• 3. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
• 4. An approach to biodegradable star polymeric architectures using disulfide coupling?
  Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584
• 5. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126

4-Bromo-2-Methyl-Pyridine-3-Carbaldehyde (CAS No. 1060805-93-7): An Overview of Its Synthesis, Properties, and Applications

4-Bromo-2-methyl-pyridine-3-carbaldehyde (CAS No. 1060805-93-7) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and organic synthesis. This compound, characterized by its unique structural features, has been extensively studied for its potential applications in drug discovery and as a key intermediate in the synthesis of various bioactive molecules.

The chemical structure of 4-bromo-2-methyl-pyridine-3-carbaldehyde consists of a pyridine ring with a bromo substituent at the 4-position, a methyl group at the 2-position, and an aldehyde functional group at the 3-position. These substituents contribute to its reactivity and make it a valuable building block in synthetic chemistry.

Recent advancements in synthetic methodologies have led to the development of efficient routes for the preparation of 4-bromo-2-methyl-pyridine-3-carbaldehyde. One notable method involves the bromination of 2-methyl-pyridine-3-carbaldehyde followed by selective bromination at the 4-position. This approach has been optimized to achieve high yields and purity, making it suitable for large-scale production.

In terms of physical properties, 4-bromo-2-methyl-pyridine-3-carbaldehyde is a solid at room temperature with a melting point of approximately 75°C. It is soluble in common organic solvents such as dichloromethane, ethanol, and dimethylformamide (DMF). The compound's solubility profile makes it easy to handle and process in various chemical reactions.

The reactivity of 4-bromo-2-methyl-pyridine-3-carbaldehyde is primarily attributed to its aldehyde functional group and the electron-withdrawing nature of the bromo substituent. This combination allows for a wide range of chemical transformations, including condensation reactions, reduction to form alcohols, and coupling reactions with nucleophiles. These reactions are crucial for the synthesis of complex molecules with diverse biological activities.

In the context of medicinal chemistry, 4-bromo-2-methyl-pyridine-3-carbaldehyde has been explored as a starting material for the synthesis of potential therapeutic agents. For instance, recent studies have demonstrated its utility in the development of novel inhibitors targeting specific enzymes involved in disease pathways. One such application involves the synthesis of pyridine-based inhibitors for kinases, which are key targets in cancer therapy.

Beyond its direct use in drug discovery, 4-bromo-2-methyl-pyridine-3-carbaldehyde serves as an important intermediate in the preparation of other bioactive compounds. Its versatility as a synthetic precursor has been leveraged in the synthesis of various heterocyclic systems with potential pharmaceutical applications. For example, it has been used to synthesize pyrazoles, pyrimidines, and other nitrogen-containing heterocycles that exhibit anti-inflammatory, antiviral, and anticancer properties.

The environmental impact and safety profile of 4-bromo-2-methyl-pyridine-3-carbaldehyde are also important considerations. While it is not classified as a hazardous material under current regulations, proper handling and storage practices are recommended to ensure safety in laboratory settings. This includes using appropriate personal protective equipment (PPE) and following standard laboratory protocols for handling organic compounds.

In conclusion, 4-bromo-2-methyl-pyridine-3-carbaldehyde (CAS No. 1060805-93-7) is a multifaceted compound with significant potential in both academic research and industrial applications. Its unique chemical structure and reactivity make it an invaluable tool for synthetic chemists and medicinal chemists alike. As research continues to uncover new applications and optimization strategies, this compound is likely to play an increasingly important role in the development of novel therapeutic agents and advanced materials.

• 531521-25-2(3-PYRIDINECARBOXALDEHYDE, 5-BROMO-2,4,6-TRIMETHYL-)
• 1196157-14-8(4-\u200bBromo-\u200b5-\u200bmethyl-\u200b2-\u200bpyridinecarbaldehyde)
• 94781-48-3(4-bromo-3-methyl-1H-Pyrrole-2-carboxaldehyde)
• 1432087-58-5(4-bromo-2,5-dimethyl-1H-pyrrole-3-carbaldehyde)
• 1956318-85-6(4-bromo-2,3-dimethylpyridine hydrochloride)
• 1060805-96-0(4-bromo-6-methyl-pyridine-3-carboxylic acid)
• 1060805-91-5(4-Bromo-6-methylnicotinaldehyde)
• 477585-20-9(4-Bromo-2,3,5-trimethylpyridine)
• 1060805-98-2(4-Bromo-2-methylnicotinic acid)
• 259807-91-5(4-Bromo-2,3-dimethylpyridine)