• 1. Alt-proteins: A promising future
• 2. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
• 3. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
• 4. An intermolecular C–C coupling reaction of iridium complexes?
  Kathrin Kutlescha,Rhett Kempe New J. Chem., 2010,34, 1954-1960
• 5. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives 2-halopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines 2-halopyridines

Introduction to 2-chloro-6-(trifluoromethyl)pyridine-4-carbonitrile (CAS No. 1196155-38-0)

2-chloro-6-(trifluoromethyl)pyridine-4-carbonitrile (CAS No. 1196155-38-0) is a highly specialized organic compound that has garnered significant attention in the field of pharmaceutical and agrochemical research. This compound, characterized by its unique structural features, serves as a crucial intermediate in the synthesis of various biologically active molecules. The presence of both chloro and trifluoromethyl substituents on the pyridine ring imparts distinct electronic and steric properties, making it a valuable building block for medicinal chemists.

The chloro group at the 2-position and the trifluoromethyl group at the 6-position of the pyridine core contribute to the compound's reactivity and its potential applications in drug discovery. The carbonitrile moiety at the 4-position further enhances its utility as a precursor for more complex molecules. This compound's structural design allows for facile functionalization, enabling researchers to explore a wide range of derivatives with tailored biological activities.

In recent years, there has been a growing interest in the development of novel compounds with enhanced pharmacological properties. 2-chloro-6-(trifluoromethyl)pyridine-4-carbonitrile has emerged as a key intermediate in the synthesis of small-molecule inhibitors targeting various therapeutic areas. Its incorporation into drug candidates has shown promise in preclinical studies, particularly in the treatment of inflammatory diseases and cancer.

One of the most compelling aspects of this compound is its role in the development of kinase inhibitors. Kinases are enzymes that play a critical role in many cellular processes, and their dysregulation is often associated with disease states. By leveraging the structural features of 2-chloro-6-(trifluoromethyl)pyridine-4-carbonitrile, researchers have been able to design molecules that selectively inhibit specific kinases, thereby modulating signaling pathways involved in disease progression.

The trifluoromethyl group is particularly noteworthy due to its ability to enhance metabolic stability and binding affinity. This substituent is frequently employed in medicinal chemistry to improve the pharmacokinetic properties of drug candidates. In addition, the chloro group can serve as a handle for further chemical modifications, allowing for the introduction of additional functional groups that may enhance biological activity.

Recent advancements in computational chemistry have further facilitated the use of 2-chloro-6-(trifluoromethyl)pyridine-4-carbonitrile in drug discovery. Molecular modeling studies have revealed that this compound can be effectively incorporated into binding pockets of target proteins, providing insights into its potential as a lead compound. These studies have also highlighted the importance of optimizing substitution patterns to maximize binding affinity and selectivity.

The synthesis of 2-chloro-6-(trifluoromethyl)pyridine-4-carbonitrile involves multi-step organic transformations that require careful optimization to ensure high yields and purity. Modern synthetic methodologies have enabled more efficient routes to this intermediate, reducing costs and improving scalability. These advancements have made it more feasible for pharmaceutical companies to explore derivatives of this compound as potential drug candidates.

In conclusion, 2-chloro-6-(trifluoromethyl)pyridine-4-carbonitrile (CAS No. 1196155-38-0) represents a significant advancement in synthetic chemistry with broad applications in pharmaceutical research. Its unique structural features make it an invaluable intermediate for the development of novel therapeutic agents targeting various diseases. As research continues to uncover new biological activities and synthetic strategies, this compound is poised to play an even greater role in future drug discovery efforts.

• 1060810-25-4([2-chloro-6-(trifluoromethyl)pyridin-4-yl]methanamine)
• 1227575-01-0(4-(Bromomethyl)-2-chloro-6-(trifluoromethyl)pyridine)
• 1804703-53-4(2-Chloro-6-(difluoromethyl)isonicotinonitrile)
• 749256-90-4(2-Chloro-4-methyl-6-trifluoromethyl-pyridine)
• 1060807-47-7(2-Chloro-6-(trifluoromethyl)pyridine-4-carbaldehyde)
• 1196154-47-8(2-chloro-4-(chloromethyl)-6-(trifluoromethyl)pyridine)
• 81565-21-1(2-chloro-4,6-bis(trifluoromethyl)pyridine)
• 1156542-25-4(6-chloro-4-(trifluoromethyl)pyridine-2-carbonitrile)
• 22123-14-4(2-Chloro-6-methyl-4-(trifluoromethyl)pyridine)
• 1227563-82-7(2-Chloro-6-(trifluoromethyl)pyridine-4-acetonitrile)