• 1. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 2. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 3. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 4. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 5. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305

3-(4-Fluorophenyl)phenylmethylamine Hydrochloride (CAS 1195901-44-0): A Comprehensive Scientific Profile

In the realm of fluorinated aromatic compounds, 3-(4-Fluorophenyl)phenylmethylamine Hydrochloride (CAS 1195901-44-0) has emerged as a compound of significant interest to researchers and pharmaceutical developers. This white to off-white crystalline powder, with its molecular formula C₁₃H₁₃FN·HCl, represents an important building block in modern medicinal chemistry and drug discovery processes.

The compound's structural features – particularly the 4-fluorophenyl group and the phenylmethylamine backbone – make it a versatile intermediate in synthesizing various biologically active molecules. Recent literature indicates growing applications in developing central nervous system (CNS) targeted compounds, aligning with current research trends in neuropharmacology. The hydrochloride salt form enhances stability and solubility, crucial factors for pharmaceutical applications.

From a chemical perspective, 3-(4-Fluorophenyl)phenylmethylamine Hydrochloride demonstrates several noteworthy characteristics. The fluorine substitution at the para position of one phenyl ring influences the compound's electronic distribution, potentially affecting its binding affinity to biological targets. This modification has become increasingly popular in drug design, as evidenced by the rising number of fluorine-containing pharmaceuticals approved in recent years.

The synthesis of CAS 1195901-44-0 typically involves multi-step organic reactions, with careful control of reaction conditions to ensure high purity. Analytical techniques like HPLC, NMR spectroscopy, and mass spectrometry are routinely employed for quality control. The compound's melting point ranges between 210-215°C, and it shows good stability under standard storage conditions (room temperature, protected from moisture).

In pharmaceutical research, this compound serves as a key intermediate for developing potential therapeutic agents. Its structural motif appears in several investigational compounds targeting neurotransmitter systems. The amine hydrochloride functionality makes it particularly valuable for creating salt forms of drug candidates, improving their pharmacokinetic properties. Researchers are exploring derivatives of 3-(4-Fluorophenyl)phenylmethylamine for various applications, though specific therapeutic uses remain under investigation.

The market for fluorinated pharmaceutical intermediates has seen steady growth, driven by increasing demand for novel drug candidates. CAS 1195901-44-0 fits well within this trend, with several contract research organizations and fine chemical suppliers listing it in their catalogs. Pricing and availability vary depending on purity requirements and order quantities, with most suppliers offering custom synthesis options.

From a safety standpoint, standard laboratory precautions apply when handling 3-(4-Fluorophenyl)phenylmethylamine Hydrochloride. While not classified as highly hazardous, proper personal protective equipment (gloves, safety glasses) and adequate ventilation are recommended. Material Safety Data Sheets (MSDS) provide detailed handling instructions for this compound.

Recent scientific literature highlights the compound's utility in structure-activity relationship (SAR) studies. Medicinal chemists frequently employ this scaffold to explore how fluorination affects biological activity, a hot topic in contemporary drug discovery. The 4-fluorophenyl group often enhances metabolic stability and membrane permeability – two critical factors in drug development.

Analytical methods for characterizing 3-(4-Fluorophenyl)phenylmethylamine Hydrochloride continue to evolve. Advanced techniques like LC-MS/MS and high-field NMR provide detailed structural information, ensuring precise quality control. These methods are particularly important for pharmaceutical applications where impurity profiles must meet stringent regulatory standards.

The compound's stability under various conditions has been extensively studied. It demonstrates good thermal stability and resistance to hydrolysis under neutral conditions. However, like many amine hydrochlorides, it may degrade under strongly basic conditions or at elevated temperatures. Proper storage in airtight containers with desiccants maintains its quality over extended periods.

In the context of green chemistry, researchers are exploring more sustainable synthetic routes to fluorinated aromatic amines. Recent advances in catalytic fluorination and flow chemistry may lead to more efficient production methods for compounds like CAS 1195901-44-0. These developments align with the pharmaceutical industry's growing emphasis on environmentally friendly manufacturing processes.

From a regulatory perspective, 3-(4-Fluorophenyl)phenylmethylamine Hydrochloride is not currently controlled under international drug conventions. However, researchers and manufacturers should stay informed about evolving regulations concerning pharmaceutical intermediates and precursor chemicals. Compliance with local and international chemical control laws remains essential for all users.

The scientific community continues to discover new applications for this versatile compound. Recent patent literature reveals its incorporation into novel molecular architectures with potential biological activity. As drug discovery paradigms shift toward more complex molecules, intermediates like 3-(4-Fluorophenyl)phenylmethylamine Hydrochloride gain increasing importance in medicinal chemistry workflows.

For researchers sourcing this material, several factors warrant consideration. Purity specifications (typically ≥95% to ≥98%), analytical certificates, and supplier reliability are crucial selection criteria. Many contract manufacturing organizations now offer custom synthesis of fluorinated aromatic compounds, providing flexibility for specialized research needs.

Looking ahead, the demand for 3-(4-Fluorophenyl)phenylmethylamine Hydrochloride and similar fluorinated building blocks will likely grow. The continued success of fluorine-containing drugs and the exploration of new therapeutic targets ensure ongoing interest in these valuable synthetic intermediates. Researchers and suppliers alike should monitor developments in this dynamic segment of fine chemicals.

• 776291-03-3(4'-Fluoro-biphenyl-4-methanamine)
• 893649-06-4([1,1'-Biphenyl]-4-methanamine,3'-fluoro-)
• 884504-18-1((4'-Fluoro[1,1'-biphenyl]-2-yl)methanamine)
• 600735-62-4([1,1'-Biphenyl]-3-methanamine, 2'-fluoro-)
• 140-75-0((4-fluorophenyl)methanamine)
• 177976-50-0(3-(4-fluorophenyl)phenylmethanamine)
• 659-41-6(4-Fluorobenzylamine Hydrochloride)
• 600735-64-6(3-(3-fluorophenyl)phenylmethanamine)
• 893649-05-3([1,1'-Biphenyl]-4-methanamine,2'-fluoro-)
• 518357-40-9(4-(4-Fluorophenyl)PhenylMethanamine Hydrochloride)