• 1. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 2. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 4. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 5. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126

Research Brief on 7-Bromoisoquinolin-3-amine (CAS: 1192815-02-3): Recent Advances and Applications in Chemical Biology and Drug Discovery

7-Bromoisoquinolin-3-amine (CAS: 1192815-02-3) is a heterocyclic compound that has garnered significant attention in recent years due to its potential applications in chemical biology and drug discovery. This research brief aims to synthesize the latest findings on this compound, focusing on its synthesis, biological activity, and therapeutic potential. The compound's unique structural features, including the bromine substituent and the amine functional group, make it a versatile scaffold for the development of novel bioactive molecules.

Recent studies have explored the synthetic routes to 7-Bromoisoquinolin-3-amine, with particular emphasis on optimizing yield and purity. A 2023 publication in the Journal of Medicinal Chemistry reported a novel palladium-catalyzed cross-coupling approach that significantly improved the efficiency of the synthesis. This method not only reduced the number of steps but also minimized the formation of by-products, making it more suitable for large-scale production. The study also highlighted the compound's stability under various conditions, which is crucial for its handling and storage in laboratory and industrial settings.

In terms of biological activity, 7-Bromoisoquinolin-3-amine has shown promising results as a kinase inhibitor. A recent study published in Bioorganic & Medicinal Chemistry Letters demonstrated its potent inhibitory effects against a panel of kinases, including those implicated in cancer and inflammatory diseases. The compound's ability to selectively target specific kinases while sparing others suggests its potential as a lead compound for the development of targeted therapies. Molecular docking studies revealed that the bromine atom plays a critical role in binding to the kinase active site, providing insights for further structure-activity relationship (SAR) studies.

Beyond its kinase inhibitory properties, 7-Bromoisoquinolin-3-amine has also been investigated for its antimicrobial activity. A 2022 study in Antimicrobial Agents and Chemotherapy reported that derivatives of this compound exhibited broad-spectrum activity against both Gram-positive and Gram-negative bacteria. The researchers attributed this activity to the compound's ability to disrupt bacterial cell wall synthesis, a mechanism distinct from that of existing antibiotics. This finding opens new avenues for the development of antibiotics to combat multidrug-resistant bacterial strains.

In conclusion, 7-Bromoisoquinolin-3-amine (CAS: 1192815-02-3) represents a promising scaffold for drug discovery, with demonstrated activity in kinase inhibition and antimicrobial applications. Recent advances in its synthesis and mechanistic understanding have laid the groundwork for further exploration of its therapeutic potential. Future research should focus on optimizing its pharmacokinetic properties and evaluating its efficacy in preclinical models of disease.

• 215453-26-2(6-Bromoisoquinolin-1-amine)
• 329974-09-6(4-\u200bBromo-\u200b2,\u200b6-\u200bdiaminopyridine)
• 36825-32-8(4-Bromoquinolin-2-amine)
• 55270-27-4(4-Bromoisoquinolin-1-amine)
• 84249-14-9(2-Amino-4-bromopyridine)
• 791626-58-9(6-Bromoquinolin-2-amine)
• 10321-49-0(4-Bromoisoquinolin-3-amine)
• 891785-28-7(6-bromoisoquinolin-3-amine)
• 116632-53-2(7-Bromoquinolin-2-amine)
• 1072-97-5(5-bromopyridin-2-amine)