• 1. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 2. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 3. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126
• 4. An approach for correlating the structural and electrical properties of Zr4+-modified SrBi4Ti4O15/SBT ceramic
  Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331
• 5. An amorphous lanthanum–iridium solid solution with an open structure for efficient water splitting?
  Wei Sun,Chenglong Ma,Xinlong Tian,Jianjun Liao,Ji Yang,Chengjun Ge,Weiwei Huang J. Mater. Chem. A, 2020,8, 12518-12525

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Tertiary amines

4-Chloro-6-pyrrolidin-1-yl-2-trifluoromethylpyrimidine: A Comprehensive Overview

The compound with CAS No. 1189872-15-8, known as 4-Chloro-6-pyrrolidin-1-yl-2-trifluoromethylpyrimidine, is a highly specialized organic molecule that has garnered significant attention in the fields of medicinal chemistry and materials science. This compound is characterized by its unique pyrimidine ring structure, which serves as a versatile scaffold for various functional groups. The presence of a chlorine atom at the 4-position, a pyrrolidinyl group at the 6-position, and a trifluoromethyl group at the 2-position endows this molecule with distinctive electronic and steric properties, making it an intriguing subject for both theoretical and experimental studies.

Recent advancements in computational chemistry have allowed researchers to delve deeper into the electronic structure of 4-Chloro-6-pyrrolidin-1-yl-2-trifluoromethylpyrimidine. Utilizing density functional theory (DFT) calculations, scientists have identified the molecule's ability to act as a potential ligand in metalloenzyme catalysis. This property is attributed to the electron-withdrawing effects of the trifluoromethyl group, which enhances the molecule's ability to coordinate with metal centers. Furthermore, the pyrrolidinyl group contributes to the molecule's flexibility, enabling it to adopt various conformations that are favorable for enzymatic interactions.

In the realm of drug discovery, 4-Chloro-6-pyrrolidin-1-yl-2-trifluoromethylpyrimidine has shown promise as a lead compound for developing inhibitors targeting kinase enzymes. Kinases play pivotal roles in cellular signaling pathways, and their dysregulation is implicated in various diseases, including cancer and inflammatory disorders. Preclinical studies have demonstrated that this compound exhibits moderate inhibitory activity against several kinases, such as Src and Abl, which are often overexpressed in malignant cells. The trifluoromethyl group has been identified as a key determinant of its selectivity profile, suggesting that further optimization could yield more potent and specific inhibitors.

Beyond its pharmacological applications, this compound has also found utility in materials science. The pyrimidine ring system serves as a building block for constructing two-dimensional (2D) covalent organic frameworks (COFs). These frameworks exhibit exceptional stability and porosity, making them ideal candidates for gas storage and separation applications. Recent research has highlighted the ability of 4-Chloro-6-pyrrolidin-1-yl-2-trifluoromethylpyrimidine to form COFs with tunable pore sizes, which can be tailored to selectively adsorb gases such as CO? and CH?. This advancement underscores the compound's versatility across diverse scientific disciplines.

The synthesis of 4-Chloro-6-pyrrolidin-1-yl-2-trifluoromethylpyrimidine involves a multi-step process that combines principles from organic synthesis and catalysis. A common approach entails the nucleophilic substitution of a chlorinated pyrimidine precursor with a pyrrolidinyl group in the presence of a palladium catalyst. The introduction of the trifluoromethyl group is typically achieved through electrophilic substitution under high-pressure conditions. Recent optimizations in reaction conditions have significantly improved the yield and purity of this compound, facilitating its widespread use in research and development.

From an environmental perspective, 4-Chloro-6-pyrrolidin-1-yliyfuranopyrimidine exhibits favorable biodegradation characteristics under aerobic conditions. Studies conducted in controlled laboratory settings have shown that microbial communities can effectively metabolize this compound into innocuous byproducts within a relatively short timeframe. This attribute aligns with current sustainability goals in chemical manufacturing, emphasizing the importance of eco-friendly practices in drug development and materials synthesis.

In conclusion, 4-Chloro-6-pyrrolidin-1-ylyfuranopyrimidine stands as a testament to the ingenuity of modern chemical research. Its unique structural features, coupled with its diverse applications across medicine and materials science, position it as a valuable tool for addressing some of today's most pressing scientific challenges. As research continues to uncover new facets of this compound's potential, it is poised to play an increasingly significant role in advancing both fundamental understanding and practical innovations.

• 175140-68-8(N-butyl-6-chloro-N-ethyl-2-methylpyrimidin-4-amine)
• 1214254-81-5(4-Chloro-2-(chloromethyl)-6-pyrrolidin-1-ylpyrimidine)
• 94052-15-0(4-chloro-2-methyl-6-(piperidin-1-yl)pyrimidine)
• 914349-69-2(4-chloro-2-methyl-6-(pyrrolidin-1-yl)pyrimidine)
• 866648-53-5((6-Chloro-2-trifluoromethylpyrimidin-4-yl)dimethyl-amine)
• 1289079-12-4(4-(Azetidin-1-yl)-6-chloro-2-methylpyrimidine)
• 1189444-94-7(4-(6-Chloro-2-trifluoromethylpyrimidin-4-yl)morpholine)
• 261765-63-3(4-Pyrimidinamine, 6-chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-)
• 1267062-78-1(4-Chloro-6-(piperazin-1-yl)-2-(trifluoromethyl)pyrimidine)
• 1023813-57-1(4-(6-Chloro-2-(trifluoromethyl)pyrimidin-4-yl)piperazine-1-carbaldehyde)