Cas no 1189112-05-7 (HO-PEG14-OH)

HO-PEG14-OH is a linear polyethylene glycol (PEG) derivative featuring terminal hydroxyl groups at both ends of a 14-unit PEG chain. This water-soluble compound is widely utilized in bioconjugation, drug delivery, and material science due to its excellent biocompatibility, low toxicity, and tunable hydrophilicity. The 14-ethylene oxide repeat units provide an optimal balance between molecular weight and flexibility, making it suitable for spacer applications in linker chemistry or surface modification. Its bifunctional hydroxyl groups enable further derivatization, facilitating crosslinking or attachment to other molecules. HO-PEG14-OH is particularly valued for its stability under physiological conditions and its ability to enhance solubility and reduce immunogenicity in therapeutic formulations.
HO-PEG14-OH structure
HO-PEG14-OH structure
Product Name:HO-PEG14-OH
CAS No:1189112-05-7
MF:C28H58O15
MW:634.751131534576
CID:2094828
Update Time:2025-05-28

HO-PEG14-OH Chemical and Physical Properties

Names and Identifiers

    • PEG-14
    • HO-14-OH
    • HO-dPEG14-OH
    • PEG15
    • tetradecaethylene glycol
    • 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
    • Q27464382
    • 3,6,9,12,15,18,21,24,27,30,33,36,39-Tridecaoxahentetracontane-1,41-diol
    • HO-PEG14-OH
    • Inchi： 1S/C28H58O15/c29-1-3-31-5-7-33-9-11-35-13-15-37-17-19-39-21-23-41-25-27-43-28-26-42-24-22-40-20-18-38-16-14-36-12-10-34-8-6-32-4-2-30/h29-30H,1-28H2
    • InChI Key： ILLKMACMBHTSHP-UHFFFAOYSA-N
    • SMILES： O(CCOCCOCCOCCOCCOCCOCCO)CCOCCOCCOCCOCCOCCOCCO

Computed Properties

  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 15
  • Heavy Atom Count: 43
  • Rotatable Bond Count: 40
  • Complexity: 439
  • Topological Polar Surface Area: 160

Experimental Properties

  • Density: 1.116±0.06 g/cm3 (20 oC 760 Torr),
  • Solubility: Extremely soluble (1000 g/l) (25 o C),

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HO-PEG14-OH Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:1189112-05-7)HO-PEG14-OH
Order Number:A945264
Stock Status:in Stock
Quantity:1g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 15:51
Price ($):219.0

HO-PEG14-OH Related Literature

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Additional information on HO-PEG14-OH

Comprehensive Overview of HO-PEG14-OH (CAS No. 1189112-05-7): Properties, Applications, and Innovations

HO-PEG14-OH, identified by its CAS number 1189112-05-7, is a high-purity polyethylene glycol (PEG) derivative widely utilized in pharmaceuticals, biotechnology, and material science. This 14-unit PEG chain terminated with hydroxyl groups at both ends offers exceptional solubility, biocompatibility, and low immunogenicity, making it a cornerstone in drug delivery systems and bioconjugation. Its unique structure enables precise control over molecular weight and functionality, addressing critical challenges in modern research and industrial applications.

The growing demand for PEG-based compounds like HO-PEG14-OH is driven by advancements in nanomedicine and targeted therapy. Researchers frequently search for "PEGylation techniques" or "HO-PEG14-OH solubility," reflecting its role in enhancing drug stability and prolonging circulation time. Recent studies highlight its use in mRNA vaccine formulations, where PEG derivatives stabilize lipid nanoparticles—a topic gaining traction due to global health initiatives. Additionally, its application in 3D bioprinting as a bioink modifier aligns with trends in regenerative medicine.

From a chemical perspective, HO-PEG14-OH (CAS 1189112-05-7) exhibits a molecular weight of approximately 700 Da, with each ethylene oxide unit contributing to its hydrophilic character. This property is pivotal for "aqueous phase reactions" and "protein PEGylation," frequently queried in academic databases. The compound’s low toxicity and FDA-approved status for certain applications further bolster its adoption in cosmetic formulations and medical devices, meeting stringent regulatory standards.

Innovations in green chemistry have also spotlighted HO-PEG14-OH as a sustainable alternative to traditional solvents. Searches for "eco-friendly PEG derivatives" underscore its role in reducing environmental impact while maintaining performance in industrial processes. Furthermore, its compatibility with click chemistry (e.g., azide-alkyne cycloaddition) enables rapid modular synthesis, a technique dominating recent literature on biomaterial engineering.

In summary, HO-PEG14-OH (CAS 1189112-05-7) represents a versatile tool bridging interdisciplinary research. Its alignment with cutting-edge fields like CRISPR delivery systems and theranostic nanoparticles ensures continued relevance. As queries for "PEGylation optimization" and "HO-PEG14-OH suppliers" rise, this compound remains pivotal in translating scientific breakthroughs into tangible solutions.

1189112-05-7 (HO-PEG14-OH) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:1189112-05-7)HO-PEG14-OH
A945264
Purity:99%
Quantity:1g
Price ($):219.0
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