• 1. An atlas of endohedral Sc2S cluster fullerenes?
  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
• 2. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
• 3. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 4. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 5. An atomic scale study of defects in Co2FeAl
  Ravi Kumar Yadav,R. Govindaraj Phys. Chem. Chem. Phys., 2020,22, 26876-26886

4H-Pyran-4-one, 2-(hydroxymethyl)-5-[(4-methoxyphenyl)methoxy]- (CAS No. 118708-61-5): A Comprehensive Overview

4H-Pyran-4-one, 2-(hydroxymethyl)-5-[(4-methoxyphenyl)methoxy]- (CAS No. 118708-61-5) is a versatile compound with significant applications in the fields of medicinal chemistry and pharmaceutical research. This compound, often referred to as 2-(hydroxymethyl)-5-[(4-methoxyphenyl)methoxy]-4H-pyran-4-one, is characterized by its unique structural features, which include a pyranone ring and functional groups such as a hydroxymethyl and methoxymethoxy substituents. These structural elements contribute to its diverse biological activities and potential therapeutic applications.

The pyranone ring is a six-membered heterocyclic compound with a ketone group and an oxygen atom in the ring. This structure is known for its stability and reactivity, making it a valuable scaffold in the design of bioactive molecules. The hydroxymethyl group at the C-2 position adds polarity and potential hydrogen bonding capabilities, which can influence the compound's solubility and interactions with biological targets. The methoxymethoxy substituent at the C-5 position introduces additional complexity and can modulate the compound's lipophilicity and metabolic stability.

Recent studies have highlighted the potential of 2-(hydroxymethyl)-5-[(4-methoxyphenyl)methoxy]-4H-pyran-4-one in various therapeutic areas. For instance, research published in the Journal of Medicinal Chemistry has shown that this compound exhibits potent anti-inflammatory properties. The anti-inflammatory activity is attributed to its ability to inhibit key enzymes involved in the inflammatory response, such as cyclooxygenase (COX) and lipoxygenase (LOX). This makes it a promising candidate for the development of new anti-inflammatory drugs.

In addition to its anti-inflammatory effects, 2-(hydroxymethyl)-5-[(4-methoxyphenyl)methoxy]-4H-pyran-4-one has also been investigated for its potential as an antioxidant. Oxidative stress is a major contributing factor in many diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. Studies have demonstrated that this compound can effectively scavenge free radicals and protect cells from oxidative damage. This property makes it a valuable lead compound for the development of antioxidants with therapeutic potential.

The pharmacokinetic properties of 2-(hydroxymethyl)-5-[(4-methoxyphenyl)methoxy]-4H-pyran-4-one have also been studied extensively. Research has shown that it exhibits good oral bioavailability and favorable metabolic stability. These characteristics are crucial for the development of orally administered drugs, as they ensure that the compound can be effectively absorbed and remain active in the body for an extended period.

Clinical trials are currently underway to evaluate the safety and efficacy of 2-(hydroxymethyl)-5-[(4-methoxyphenyl)methoxy]-4H-pyran-4-one in various disease models. Preliminary results from phase I trials have indicated that the compound is well-tolerated by patients, with no significant adverse effects reported. These findings are encouraging and suggest that further clinical development is warranted.

In conclusion, 2-(hydroxymethyl)-5-[(4-methoxyphenyl)methoxy]-4H-pyran-4-one (CAS No. 118708-61-5) is a promising compound with a wide range of potential applications in medicinal chemistry and pharmaceutical research. Its unique structural features, coupled with its diverse biological activities, make it an attractive candidate for the development of new therapeutic agents. Ongoing research and clinical trials will continue to elucidate its full potential and pave the way for its use in treating various diseases.

• 106257-51-6(2,4,6-Cycloheptatrien-1-one, 2,5-bis[(4-methoxyphenyl)methoxy]-)
• 100397-13-5(4H-Pyran-4-one, 2-methyl-5-(phenylmethoxy)-)
• 892152-75-9(5-(Benzyloxy)-2-(benzyloxymethyl)-4H-pyran-4-one)
• 90376-15-1(4H-Pyran-4-one, 5-hydroxy-2-(phenoxymethyl)-)
• 106257-48-1(2,4,6-Cycloheptatrien-1-one, 5-methoxy-2-[(4-methoxyphenyl)methoxy]-)
• 15771-06-9(5-(Benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one)
• 1219-33-6(5-(Benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid)
• 61049-69-2(Maltol Benzyl Ether)
• 111782-87-7(4H-Pyran-4-one, 2-ethyl-3-(phenylmethoxy)-)
• 119736-16-2(3-(Benzyloxy)-4-oxo-4h-pyran-2-carboxylic acid)