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  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 2. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
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• 3. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Aminopyrimidines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Aminopyrimidines and derivatives

N-(Piperidin-3-yl)pyrimidin-2-amine Hydrochloride (CAS 1185312-44-0): A Comprehensive Overview

N-(Piperidin-3-yl)pyrimidin-2-amine hydrochloride (CAS 1185312-44-0) is a specialized chemical compound that has garnered significant attention in pharmaceutical and biochemical research. This piperidine-pyrimidine derivative is known for its unique structural properties, making it a valuable intermediate in drug discovery and development. With the increasing demand for novel therapeutic agents, compounds like N-(Piperidin-3-yl)pyrimidin-2-amine HCl are being extensively studied for their potential applications in treating various diseases.

The molecular structure of N-(Piperidin-3-yl)pyrimidin-2-amine hydrochloride combines a piperidine ring with a pyrimidine moiety, which is a common scaffold in many bioactive molecules. This combination enhances its binding affinity to biological targets, particularly in the central nervous system (CNS). Researchers are particularly interested in its role as a kinase inhibitor or GPCR modulator, which aligns with current trends in precision medicine and targeted therapies.

One of the most searched questions about CAS 1185312-44-0 relates to its solubility and stability. This compound is typically soluble in water and polar organic solvents, making it suitable for various experimental conditions. Its hydrochloride salt form improves bioavailability, a critical factor in drug development. Recent studies have explored its potential in neurodegenerative disease research, a hot topic in 2024 due to the rising global prevalence of conditions like Alzheimer's and Parkinson's.

From a synthetic chemistry perspective, N-(Piperidin-3-yl)pyrimidin-2-amine HCl serves as a versatile building block. Its amine-functionalized piperidine core allows for further derivatization, enabling researchers to create libraries of compounds for high-throughput screening. This approach is particularly valuable in fragment-based drug design, another trending area in pharmaceutical research.

The pharmaceutical industry shows growing interest in piperidine-containing compounds like 1185312-44-0 due to their improved pharmacokinetic properties. Market analyses indicate increasing demand for such intermediates, especially in the development of CNS-targeting drugs and anticancer agents. This aligns with current healthcare priorities and the ongoing search for more effective treatments with fewer side effects.

Quality control is paramount when working with N-(Piperidin-3-yl)pyrimidin-2-amine hydrochloride. Analytical methods such as HPLC and LC-MS are commonly employed to ensure purity and consistency. Researchers frequently search for proper storage conditions - this compound should be kept in a cool, dry environment, protected from light and moisture to maintain stability.

Recent advancements in computational chemistry and AI-assisted drug discovery have brought renewed attention to compounds like CAS 1185312-44-0. Virtual screening techniques can predict its interactions with various biological targets, accelerating the identification of potential therapeutic applications. This synergy between experimental and computational approaches represents the cutting edge of modern drug development.

From a regulatory perspective, N-(Piperidin-3-yl)pyrimidin-2-amine HCl is classified as a research chemical. It's important to note that proper safety protocols must be followed when handling this material, including the use of personal protective equipment. While not classified as hazardous under standard conditions, prudent laboratory practices should always be observed.

The future outlook for 1185312-44-0 appears promising. With ongoing research into its pharmacological properties and potential therapeutic applications, this compound may play a significant role in the development of next-generation medications. Its structural features make it particularly interesting for addressing unmet medical needs in neurology and oncology.

For researchers sourcing N-(Piperidin-3-yl)pyrimidin-2-amine hydrochloride, it's crucial to work with reputable suppliers who can provide comprehensive analytical data and certificates of analysis. The compound's quality can significantly impact research outcomes, making supplier selection a critical consideration in experimental design.

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