• 1. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 2. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 3. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
  José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
• 4. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 5. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312

Comprehensive Overview of 4-Bromo-1-[(oxan-2-yl)methyl]-1H-pyrazole (CAS No. 1183588-29-5)

4-Bromo-1-[(oxan-2-yl)methyl]-1H-pyrazole (CAS No. 1183588-29-5) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research. This brominated pyrazole derivative features a unique tetrahydropyranylmethyl substitution, which enhances its reactivity and potential applications in drug discovery. Researchers are particularly interested in its role as a versatile building block for synthesizing biologically active molecules, given its ability to participate in cross-coupling reactions and serve as a pharmacophore scaffold.

The compound’s molecular structure combines a pyrazole core with a 4-bromo substituent and a tetrahydropyranylmethyl group, making it a valuable intermediate in medicinal chemistry. Recent studies highlight its utility in developing kinase inhibitors and antimicrobial agents, aligning with the growing demand for novel therapeutic candidates. Its CAS No. 1183588-29-5 is frequently searched in scientific databases, reflecting its relevance in high-throughput screening and structure-activity relationship (SAR) studies.

In the context of green chemistry, 4-Bromo-1-[(oxan-2-yl)methyl]-1H-pyrazole has been explored for its potential in sustainable synthesis. The compound’s stability under mild reaction conditions makes it suitable for catalytic transformations, a topic of high interest in industrial R&D. Additionally, its low toxicity profile (as per available data) positions it as a safer alternative to traditional halogenated intermediates, addressing environmental concerns in chemical manufacturing.

From a commercial perspective, the demand for CAS 1183588-29-5 is driven by its applications in custom synthesis and contract research organizations (CROs). Suppliers often highlight its high purity (>98%) and compatibility with Pd-catalyzed reactions, which are critical for API development. The compound’s long-term storage stability further enhances its appeal for large-scale procurement.

Emerging trends in AI-driven drug discovery have also spotlighted 4-Bromo-1-[(oxan-2-yl)methyl]-1H-pyrazole as a candidate for virtual screening libraries. Computational models frequently incorporate its structural features to predict bioactivity against targets like G-protein-coupled receptors (GPCRs). This aligns with the pharmaceutical industry’s focus on rational drug design and fragment-based lead discovery.

In summary, 4-Bromo-1-[(oxan-2-yl)methyl]-1H-pyrazole (CAS No. 1183588-29-5) represents a multifaceted tool for modern chemical research. Its synthetic flexibility, biological relevance, and commercial accessibility make it a compound of enduring interest across academia and industry. Future studies may explore its derivatives for niche applications in material science or bioconjugation, further expanding its utility.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)