Cas no 1179609-46-1 (2-fluoro-4-(2-methoxyphenyl)benzoic Acid)

2-Fluoro-4-(2-methoxyphenyl)benzoic acid is a fluorinated aromatic carboxylic acid derivative with a methoxyphenyl substituent, offering unique structural features for synthetic and pharmaceutical applications. Its fluorine atom enhances metabolic stability and binding affinity, while the methoxy group contributes to electronic modulation and solubility. This compound serves as a versatile intermediate in medicinal chemistry, particularly in the development of bioactive molecules targeting CNS disorders or inflammation. The benzoic acid moiety allows for further functionalization, enabling conjugation or salt formation. High purity and well-defined reactivity make it suitable for precision synthesis in drug discovery and material science research. Its balanced lipophilicity aids in optimizing pharmacokinetic properties in lead optimization studies.
2-fluoro-4-(2-methoxyphenyl)benzoic Acid structure
1179609-46-1 structure
Product Name:2-fluoro-4-(2-methoxyphenyl)benzoic Acid
CAS No:1179609-46-1
MF:C14H11FO3
MW:246.233747720718
MDL:MFCD12859208
CID:1207627
PubChem ID:53211101
Update Time:2025-06-21

2-fluoro-4-(2-methoxyphenyl)benzoic Acid Chemical and Physical Properties

Names and Identifiers

    • 2-fluoro-4-(2-methoxyphenyl)benzoic Acid
    • DTXSID20681133
    • 3-Fluoro-2'-methoxy[1,1'-biphenyl]-4-carboxylic acid
    • AKOS005820883
    • 1179609-46-1
    • MFCD12859208
    • 2-Fluoro-4-(2-methoxyphenyl)benzoic acid, 95%
    • MDL： MFCD12859208
    • Inchi： 1S/C14H11FO3/c1-18-13-5-3-2-4-10(13)9-6-7-11(14(16)17)12(15)8-9/h2-8H,1H3,(H,16,17)
    • InChI Key： UHROEDFMTLAQAI-UHFFFAOYSA-N
    • SMILES： FC1=C(C(=O)O)C=CC(=C1)C1C=CC=CC=1OC

Computed Properties

  • Exact Mass: 246.06922237g/mol
  • Monoisotopic Mass: 246.06922237g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 18
  • Rotatable Bond Count: 3
  • Complexity: 295
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.1
  • Topological Polar Surface Area: 46.5?2

2-fluoro-4-(2-methoxyphenyl)benzoic Acid Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
abcr
AB326513-5 g
2-Fluoro-4-(2-methoxyphenyl)benzoic acid, 95%; .
 1179609-46-1 95%
5g
 €1159.00 2023-06-21
abcr
AB326513-5g
2-Fluoro-4-(2-methoxyphenyl)benzoic acid, 95%; .
 1179609-46-1 95%
5g
 €1159.00 2025-04-22

2-fluoro-4-(2-methoxyphenyl)benzoic Acid Related Literature

Additional information on 2-fluoro-4-(2-methoxyphenyl)benzoic Acid

2-Fluoro-4-(2-Methoxyphenyl)Benzoic Acid: A Comprehensive Overview

The compound 2-fluoro-4-(2-methoxyphenyl)benzoic acid, identified by the CAS number 1179609-46-1, is a significant molecule in the field of organic chemistry and pharmacology. This compound has garnered attention due to its unique structural properties and potential applications in drug discovery and material science. In this article, we delve into the chemical structure, synthesis, properties, and recent advancements in research related to this compound.

The molecular structure of 2-fluoro-4-(2-methoxyphenyl)benzoic acid comprises a benzoic acid backbone with two substituents: a fluoro group at the 2-position and a methoxy-substituted phenyl group at the 4-position. This arrangement imparts distinct electronic and steric properties to the molecule, making it a versatile building block for various chemical transformations. The presence of the methoxy group introduces electron-donating effects, while the fluoro group contributes electron-withdrawing characteristics, creating a balance that is often desirable in pharmaceutical compounds.

Recent studies have explored the synthesis of 2-fluoro-4-(2-methoxyphenyl)benzoic acid through various routes, including Friedel-Crafts acylation and Ullmann coupling reactions. These methods have been optimized to enhance yield and purity, making the compound more accessible for large-scale production. Researchers have also investigated the stereochemistry of the molecule, revealing that the spatial arrangement of substituents plays a critical role in its reactivity and biological activity.

In terms of applications, 2-fluoro-4-(2-methoxyphenyl)benzoic acid has shown promise in medicinal chemistry as a lead compound for anti-inflammatory and anticancer agents. Preclinical studies have demonstrated its ability to inhibit key enzymes involved in inflammation pathways, suggesting potential therapeutic benefits. Additionally, its derivatives have been explored for their antiproliferative effects on cancer cells, highlighting its role in oncology research.

The compound's stability under various conditions has also been a focus of recent investigations. Studies indicate that 2-fluoro-4-(2-methoxyphenyl)benzoic acid exhibits good thermal stability and resistance to hydrolysis, making it suitable for use in diverse chemical environments. Its solubility properties have been optimized through structural modifications, further expanding its applicability in drug delivery systems.

In conclusion, 2-fluoro-4-(2-methoxyphenyl)benzoic acid (CAS No. 1179609-46-1) is a multifaceted compound with significant potential across multiple disciplines. Its unique structure, coupled with recent advancements in synthesis and application studies, positions it as a valuable asset in both academic research and industrial development.

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