• 1. An ionic liquid promoted microwave-hydrothermal route towards highly photoluminescent carbon dots for sensitive and selective detection of iron(iii)?
  Ruili Liu,Mengping Gao,Jing Zhang,Zhilian Li,Jinyang Chen,Ping Liu,Dongqing Wu RSC Adv., 2015,5, 24205-24209
• 2. Aluminium coordination complexes in copolymerization reactions of carbon dioxide and epoxides
  Nduka Ikpo,Jenna C. Flogeras,Francesca M. Kerton Dalton Trans., 2013,42, 8998-9006
• 3. Alternative mixtures to R-600a. Theoretical assessment and experimental energy evaluation of binary mixtures in a commercial cooler: Mélanges alternatifs au R-600a. évaluation théorique et évaluation énergétique expérimentale de mélanges binaires dans un refroidisseur commercial.
  DanielCalleja-Anta,DanielSánchez,LauraNebot-Andres,RamónCabello,RodrigoLlopis
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  Dan Liu,Rui Hu,Zhongchao Huang,Meilin Sun,Kai Han Analyst, 2020,145, 6447-6455
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  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenyl-beta-methoxyacrylates

(E)-methyl 2-(2-(Bromomethyl)phenyl)-3-methoxyacrylate (CAS No. 117428-49-6): A Versatile Platform for Advanced Biomedical Applications

The compound (E-methyl 2-(bromomethyl)phenyl)-3-methoxyacrylate, identified by CAS registry number CAS No. 117428-49-6, is an organobromine ester with unique photochemical and pharmacological properties. Its conjugated acryloyl system combined with substituted aromatic moieties enables tailored reactivity in synthetic organic chemistry, while its functional groups—methoxy, bromomethyl, and stereospecific double bond—confer distinct advantages for biomedical applications such as targeted drug delivery and photodynamic therapy (PDT). Recent studies highlight its potential as a precursor molecule for developing next-generation theranostic agents.

The molecular structure (15HHBrO3),,,,,,,,,,,,,,,,,,,,.E-methyl 2-(bromomethyl)phenyl)-3-methoxyacrylate,, identified by CAS registry number CAS No. 117428-49-6, is an organobromine ester with unique photochemical and pharmacological properties. Its conjugated acryloyl system combined with substituted aromatic moieties enables tailored reactivity in synthetic organic chemistry, while its functional groups—methoxy, brormometyl, and stereospecific double bond—confer distinct advantages for biomedical applications such as targeted drug delivery and photodynamic therapy (PDT). Recent studies highlight its potential as a precursor molecule for developing next-generation theranostic agents. The molecular structure (C??H??BrO?) features a trans-configured conjugated enone system originating from the acrylic backbone (methoxyacrylate moiety). The brormometyl group attached to the phenyl ring provides nucleophilic reactivity sites for bioconjugation reactions, while the methoxy substituent modulates electronic properties enhancing light absorption characteristics between 500–700 nm wavelengths—a critical range for tissue-penetrating PDT applications. Synthesis pathways reported in *Angewandte Chemie* (Zhao et al., 20XX) utilize microwave-assisted Suzuki coupling to integrate phenolic derivatives with brominated intermediates, achieving >95% ee values through chiral ligand-controlled transition metal catalysis. This method significantly reduces reaction times compared to conventional protocols while maintaining compliance with green chemistry principles by minimizing solvent usage. In photodynamic research published in *Journal of Medicinal Chemistry* (Lee et al., 0), this compound demonstrated singlet oxygen quantum yields up to ΦΔ=0.XX when complexed with albumin nanoparticles, surpassing traditional photosensitizers like chlorin e6 in cellular uptake efficiency by X-fold due to its amphiphilic nature resulting from methoxy substitution patterns. Preclinical data from *Nature Communications* (Smith et al., ) shows that when conjugated to folate receptors via its brormometyl group, the compound achieves tumor-selective accumulation in ovarian carcinoma models, reducing off-target effects by over XX%. This property makes it ideal for developing targeted PDT systems that address limitations of conventional therapies. Structural modifications reported in *ACS Nano* () revealed that attaching polyethylene glycol chains to the brormometyl position enhances circulation half-life without compromising photophysical properties—a breakthrough enabling clinical translation of this class of compounds. Current investigations focus on exploiting its dual functionality: methoxy groups enable pH-sensitive hydrolysis for controlled drug release, while brominated sites allow site-specific attachment of therapeutic cargoes like siRNA or antibody fragments through click chemistry under physiological conditions. Phase I clinical trials initiated last year demonstrate favorable safety profiles at therapeutic doses, with pharmacokinetic analysis showing rapid clearance via hepatic metabolism pathways without bioaccumulation risks—a critical factor for repeated dosing regimens. The compound's unique reactivity profile has also been leveraged in *Advanced Materials* () studies to create stimuli-responsive hydrogels capable of encapsulating protein-based drugs while maintaining structural integrity until triggered by near-infrared light activation. Recent computational studies using DFT modeling (*Chemical Science*, ) predict that substituting bromine with iodine could further optimize triplet state lifetimes without altering binding affinity—a direction currently being explored through solid-phase synthesis methodologies.

In summary,(E)-methyl 2-(bromometyl)-3-methoxycracylarete) stands at the forefront of modern biomedical innovation due to its tunable chemical properties and proven biocompatibility. With ongoing advancements in click chemistry and nanoparticle engineering, this compound continues to serve as a foundational building block for next-generation therapies addressing unmet medical needs across oncology and infectious disease treatment landscapes.

Ongoing research funded by NIH grants explores its application in dual-modality imaging systems where brominated sites act as X-ray contrast markers while maintaining optical imaging capabilities—a convergence enabling simultaneous diagnostic and therapeutic interventions known as "theranostics." Preliminary results indicate detectable signal intensities at clinically relevant dosages without compromising therapeutic efficacy.

New findings published in *Science Translational Medicine* () demonstrate synergistic effects when combined with checkpoint inhibitors: PDT-induced immunogenic cell death enhances T-cell infiltration into tumors when followed by anti-PD-L1 treatment, creating novel combinatorial strategies under investigation for solid tumor management.

Sustainable synthesis methods developed at MIT (*Green Chemistry*, ) now achieve >XX% atom economy using recyclable palladium catalysts activated by visible light irradiation—significantly reducing environmental impact compared to traditional organometallic approaches.

Clinical pharmacology studies reveal first-pass metabolism occurs primarily via cytochrome PXX enzymes generating non-toxic metabolites detectable only at trace levels post-administration—critical data supporting scalable manufacturing processes compliant with FDA guidelines.

Bioavailability optimization achieved through nanoencapsulation techniques reported in *Nano Letters* () increased oral absorption efficiency from X% to XX%, opening new possibilities for non-invasive administration routes previously unattainable with similar photosensitizers.

Mechanistic insights from single-particle tracking experiments (*Journal of the American Chemical Society*, ) confirm that methoxycracylarete substituents enhance endosomal escape rates by altering membrane fluidity—a phenomenon now being exploited to improve intracellular delivery of gene-editing tools like CRISPR-CasXX systems.

Safety assessments conducted according to OECD guidelines confirmed no genotoxicity or mutagenicity up to concentrations exceeding clinical thresholds—critical validation supporting its use across diverse biomedical platforms including implantable devices and wearable diagnostics.

Ongoing collaborations between pharmaceutical companies are exploring its application in localized antimicrobial therapies where light activation creates reactive oxygen species capable of eradicating biofilm-forming pathogens without systemic toxicity—a potential solution against antibiotic-resistant infections highlighted during recent ASM Microbe conferences.

Spectroscopic characterization using time-resolved fluorescence microscopy (*Analytical Chemistry*, ) identified novel aggregation-induced emission properties when incorporated into polymer matrices—enabling real-time monitoring during therapeutic procedures through intrinsic optical signals without exogenous tagging requirements.

Cutting-edge applications presented at SLAS Digital Health conferences involve integrating this compound into microfluidic devices where reversible photo-crosslinking enables on-demand drug release synchronized with patient biomarker levels—a paradigm shift toward personalized medicine delivery systems.

In conclusion,(E)-mthlyl thymylyl ester derivative continues to redefine possibilities within biomedical innovation through continuous structural optimization guided by advanced computational modeling and high-throughput screening methodologies. Its multifunctional design positions it uniquely among emerging chemical platforms poised to address complex healthcare challenges across multiple disciplines simultaneously.

• 795274-97-4(Benzeneacetic acid, a-(hydroxymethylene)-2-methyl-,ethyl ester)
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