Cas no 1173023-92-1 (Leuco Gentian Violet-d6 (Major))
Leuco Gentian Violet-d6 (Major) Chemical and Physical Properties
Names and Identifiers
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- Leuco Gentian Violet-d6
- 4-[[4-[bis(trideuteriomethyl)amino]phenyl]-[4-(dimethylamino)phenyl]methyl]-N,N-dimethylaniline
- Bis(4-dimethylaminophenyl)-4-dimethylamino-d6-phenylmethane
- Leuco Basic Violet 3-d6
- Leucocrystal Violet-d6
- Leucomethyl Green-d6
- Leucocrystal Violet D6; Benzenamine, 4,4'-[[4-[di(methyl-d3)amino]phenyl]methylene]bis[N,N-dimethyl-
- Leucocrystal Violet D6 100 microg/mL in Acetonitrile
- 4,4',4''-Methylidynetris[N,N-dimethylbenzenamine-d6
- Leucocrystal violet D6
- 1173023-92-1
- HY-D0233S
- DTXSID30705475
- CS-0375315
- 4,4',4''-Methylidynetris[N,N-dimethylaniline-d6
- DISCONTINUED. Please see L330203.
- SCHEMBL22157650
- Leuco Gentian Violet-d6 (Major)
- J-003597
- Leucocrystal Violet-d6, analytical standard
- DA-54867
-
- MDL： MFCD11975211
- Inchi： 1S/C25H31N3/c1-26(2)22-13-7-19(8-14-22)25(20-9-15-23(16-10-20)27(3)4)21-11-17-24(18-12-21)28(5)6/h7-18,25H,1-6H3/i1D3,2D3
- InChI Key： OAZWDJGLIYNYMU-WFGJKAKNSA-N
- SMILES： N(C([2H])([2H])[2H])(C([2H])([2H])[2H])C1C=CC(=CC=1)C(C1C=CC(=CC=1)N(C)C)C1C=CC(=CC=1)N(C)C
Computed Properties
- Exact Mass: 379.28900
- Monoisotopic Mass: 379.289458477g/mol
- Isotope Atom Count: 6
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 28
- Rotatable Bond Count: 6
- Complexity: 370
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 5.7
- Topological Polar Surface Area: 9.7?2
Experimental Properties
- Density: 1.1±0.1 g/cm3
- Boiling Point: 529.8±50.0 °C at 760 mmHg
- Flash Point: 281.8±20.7 °C
- PSA: 9.72000
- LogP: 5.06480
- Vapor Pressure: 0.0±1.4 mmHg at 25°C
Leuco Gentian Violet-d6 (Major) Security Information
-
Symbol:
- Signal Word：Warning
- Hazard Statement： H315-H319-H335
- Warning Statement： P261-P305+P351+P338
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Hazard Category Code： 36/37/38
- Safety Instruction： 26-36
-
Hazardous Material Identification：
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
Leuco Gentian Violet-d6 (Major) Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 32834-10MG |
Leuco Gentian Violet-d6 (Major) |
1173023-92-1 | 10mg |
￥3993.75 | 2024-12-26 | ||
| SHANG HAI SHAO YUAN SHI JI Co., Ltd. | A01_919179-25MG |
Leuco Gentian Violet-D6, 98%, 98 atom% |
1173023-92-1 | 98% | 25MG |
￥2300.0 | 2022-09-28 | |
| SHANG HAI BI DE YI YAO KE JI GU FEN Co., Ltd. | BD01095924-10mg |
4,4'-[[4-[Di(methyl-d3)amino]phenyl]methylene]bis[N,N-dimethylbenzenamine] |
1173023-92-1 | 98% 98%atom%D | 10mg |
￥2041.0 | 2022-09-28 | |
| AN HUI ZE SHENG Technology Co., Ltd. | 32834-10MG |
4,4'-((4-(bis(methyl-d3)amino)phenyl)methylene)bis(n,n-dimethylaniline) |
1173023-92-1 | 10mg |
￥3688.76 | 2023-09-15 | ||
| AN HUI ZE SHENG Technology Co., Ltd. | L330202-5mg |
4,4'-((4-(bis(methyl-d3)amino)phenyl)methylene)bis(n,n-dimethylaniline) |
1173023-92-1 | 5mg |
￥1500.00 | 2023-09-15 | ||
| AN HUI ZE SHENG Technology Co., Ltd. | L330202-50mg |
4,4'-((4-(bis(methyl-d3)amino)phenyl)methylene)bis(n,n-dimethylaniline) |
1173023-92-1 | 50mg |
￥12000.00 | 2023-09-15 | ||
| AN HUI ZE SHENG Technology Co., Ltd. | CS-W-00329-5ea |
4,4'-((4-(bis(methyl-d3)amino)phenyl)methylene)bis(n,n-dimethylaniline) |
1173023-92-1 | 5ea |
￥1280.00 | 2023-09-15 | ||
| AN HUI ZE SHENG Technology Co., Ltd. | CS-W-00329-50ea |
4,4'-((4-(bis(methyl-d3)amino)phenyl)methylene)bis(n,n-dimethylaniline) |
1173023-92-1 | 50ea |
￥9960.00 | 2023-09-15 | ||
| SHANG HAI YUAN YE Biotechnology Co., Ltd. | B70804-10mg |
Leuco crystal violet-D6 |
1173023-92-1 | , | 10mg |
￥3800.00 | 2022-09-28 | |
| SHANG HAI YUAN YE Biotechnology Co., Ltd. | Y17266-25mg |
Leuco crystal violet-D6 |
1173023-92-1 | D：98%；99% | 25mg |
￥2600.00 | 2022-09-28 |
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Leuco Gentian Violet-d6 (Major) Related Literature
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Michael Kappl,Paul M. Young,Daniela Traini,Sanyog Jain RSC Adv., 2016,6, 25789-25798
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Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
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Hailing Chen,Lu Yin,Meng Liu,Laibing Wang,Michiya Fujiki,Wei Zhang RSC Adv., 2019,9, 4849-4856
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Sandip Gangadhar Balwe,Yeon Tae Jeong Org. Biomol. Chem., 2018,16, 1287-1296
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Ravi Kumar Yadav,R. Govindaraj Phys. Chem. Chem. Phys., 2020,22, 26876-26886
Additional information on Leuco Gentian Violet-d6 (Major)
Research Brief on Leuco Gentian Violet-d6 (Major) and Its Applications in Chemical Biology and Medicine
Leuco Gentian Violet-d6 (Major), a deuterated derivative of Gentian Violet (CAS: 1173023-92-1), has garnered significant attention in recent chemical biology and pharmaceutical research due to its unique properties and potential applications. This research brief synthesizes the latest findings on this compound, focusing on its synthesis, analytical applications, and therapeutic potential. The deuterated form, Leuco Gentian Violet-d6, is particularly valuable in mass spectrometry and NMR studies as an internal standard, enabling precise quantification and metabolic tracking in complex biological systems.
Recent studies have demonstrated the compound's stability and utility in pharmacokinetic research. A 2023 study published in the Journal of Labelled Compounds and Radiopharmaceuticals detailed an improved synthetic route for Leuco Gentian Violet-d6 (Major) with 98% isotopic purity, addressing previous challenges in deuteration efficiency. The research team utilized a palladium-catalyzed hydrogen-deuterium exchange method, which showed superior selectivity for the six designated deuterium positions compared to traditional acid-catalyzed exchange protocols.
In analytical chemistry applications, Leuco Gentian Violet-d6 (Major) has proven instrumental in developing sensitive LC-MS/MS methods for detecting gentian violet residues in food products and biological samples. A collaborative study between academic and regulatory researchers validated a novel method achieving 0.1 ppb detection limits in fish tissue, with the deuterated internal standard effectively compensating for matrix effects and ionization variability. This advancement addresses growing concerns about gentian violet's potential carcinogenicity in food safety monitoring.
The biomedical applications of Leuco Gentian Violet-d6 (Major) extend to antimicrobial research, where its parent compound has shown activity against drug-resistant pathogens. Current investigations focus on using the deuterated analog to study metabolic pathways in microbial systems, particularly in biofilm formation. Preliminary data suggest that deuterium incorporation may alter the compound's interaction with microbial enzymes, potentially leading to new insights into resistance mechanisms.
Ongoing clinical research explores the diagnostic potential of Leuco Gentian Violet-d6 (Major) in cancer detection. Its selective accumulation in certain tumor types, combined with the distinct mass spectral signature from deuterium substitution, offers advantages for mass spectrometry imaging techniques. A recent preclinical study demonstrated successful tumor margin delineation in head and neck squamous cell carcinoma models using this approach.
Future research directions for Leuco Gentian Violet-d6 (Major) include expanded applications in drug metabolism studies and the development of novel deuterated therapeutics. The compound's stability and well-characterized properties make it an excellent model for studying deuterium isotope effects in pharmaceutical compounds. Several research groups are investigating whether deuterium incorporation in the leuco gentian violet scaffold could enhance therapeutic efficacy while reducing toxicity.
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