• 1. XXIV.—The nitration of m-bromophenol
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• 2. Organic chemistry
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• 3. Diversity-orientated synthesis of macrocyclic heterocycles using a double SNAr approach
  Piotr Raubo,Rodrigo J. Carbajo,William McCoull,Joanna Raubo,Morgan Thomas Org. Biomol. Chem. 2021 19 6274

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenols Nitrophenols
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

Comprehensive Overview of 3-Bromo-5-nitrophenol (CAS No. 116632-23-6): Properties, Applications, and Industry Insights

3-Bromo-5-nitrophenol (CAS No. 116632-23-6) is a halogenated nitroaromatic compound widely recognized for its versatile applications in organic synthesis and specialty chemicals. With the molecular formula C₆H₄BrNO₃, this compound features a phenol core substituted with a bromine atom at the 3-position and a nitro group at the 5-position. Its unique structural attributes make it a valuable intermediate in pharmaceuticals, agrochemicals, and advanced material research. The growing demand for halogenated phenols and nitroaromatic derivatives in R&D underscores its significance in modern chemistry.

The synthesis of 3-Bromo-5-nitrophenol typically involves nitration or bromination reactions, optimized for high yield and purity. Researchers frequently explore its reactivity in coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig cross-couplings, to construct complex molecular architectures. Recent studies highlight its role in developing fluorescent probes and photoactive materials, aligning with trends in sustainable chemistry and green synthesis. As industries prioritize eco-friendly solvents and catalytic processes, this compound’s adaptability to aqueous-phase reactions has garnered attention.

From an analytical perspective, 3-Bromo-5-nitrophenol exhibits distinct spectroscopic properties. NMR and IR spectra confirm its structural integrity, while HPLC methods ensure precise quantification in formulations. Its stability under controlled conditions makes it suitable for long-term storage, though precautions against light and moisture are recommended. Regulatory compliance, including REACH and TSCA registrations, further validates its safe handling protocols.

Emerging applications of 3-Bromo-5-nitrophenol extend to bioconjugation chemistry and drug discovery, where its electrophilic sites facilitate selective modifications. For instance, it serves as a precursor in synthesizing kinase inhibitors or antimicrobial agents, addressing global health challenges. The compound’s compatibility with high-throughput screening platforms also enhances its utility in pharmaceutical innovation.

Market trends indicate rising interest in custom synthesis and scalable production of 116632-23-6, driven by demand from Asia-Pacific and North American regions. Suppliers emphasize GMP-grade manufacturing to meet stringent quality standards, while patent filings reveal novel derivatives for niche applications. For researchers, optimizing atom economy and waste reduction in its synthesis remains a focal point.

In conclusion, 3-Bromo-5-nitrophenol exemplifies the intersection of traditional organic chemistry and cutting-edge industrial needs. Its multifaceted roles—from intermediate synthesis to material science—underscore its enduring relevance. Future advancements may explore its potential in renewable energy sectors or biodegradable polymers, reflecting the compound’s adaptability to evolving scientific paradigms.

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