Diversity-orientated synthesis of macrocyclic heterocycles using a double SNAr approach?
Organic & Biomolecular Chemistry Pub Date: 2021-06-25 DOI: 10.1039/D1OB00612F
Abstract
An efficient macrocyclisation approach based on the double aromatic nucleophilic substitution (SNACK) was developed. This methodology allows a facile incorporation of heterocyclic motifs into macrocyclic rings and rapid synthesis of a significant number of structurally diverse macrocycles. SNACK macrocyclisation enables preparation of stable diastereoisomers of conformationally restricted macrocycles (atropisomers). Practical application of SNACK macrocyclisation in a drug discovery project was exemplified by the identification of high affinity macrocyclic binders of B-cell lymphoma 6 (BCL6).
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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