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Comprehensive Guide to Uridine-5'-triphosphate Trisodium Salt Dihydrate (CAS No. 116295-90-0): Properties, Applications, and Innovations

Uridine-5'-triphosphate Trisodium Salt Dihydrate (CAS No. 116295-90-0) is a biologically significant nucleotide derivative widely utilized in biochemical research, pharmaceutical development, and diagnostic applications. This compound, often abbreviated as UTP Trisodium Salt, plays a pivotal role in cellular metabolism, RNA synthesis, and energy transfer processes. Its unique chemical structure and high purity make it indispensable in modern life sciences.

The molecular formula of Uridine-5'-triphosphate Trisodium Salt Dihydrate is C₉H₁₂N₂O₁₅P₃Na₃·2H₂O, with a molecular weight of 586.11 g/mol. As a hydrated trisodium salt, it exhibits excellent solubility in aqueous solutions, making it ideal for in vitro and in vivo studies. Researchers frequently employ this compound in PCR amplification, cell culture, and enzyme assays, where its stability and reactivity are critical.

Recent advancements in genetic engineering and mRNA vaccine technology have spurred renewed interest in UTP Trisodium Salt. Its role as a precursor in RNA synthesis aligns with the growing demand for nucleotide-based therapeutics. For instance, the compound's application in transcription kits and capping analogs has become a hot topic among biotech companies exploring next-generation gene therapies and vaccine platforms.

From a quality perspective, high-grade Uridine-5'-triphosphate Trisodium Salt Dihydrate must meet stringent HPLC and NMR purity standards (>98%). Suppliers often highlight its low endotoxin levels and sterility, which are crucial for sensitive applications like cell-based assays and clinical diagnostics. Storage recommendations typically include -20°C conditions to maintain stability, though some studies suggest lyophilized forms may offer extended shelf life.

The commercial landscape for CAS 116295-90-0 reflects its diverse utility. Major distributors categorize it under research chemicals, biochemical reagents, or pharmaceutical intermediates. Pricing varies based on purity grades, with GMP-grade material commanding premium values for therapeutic applications. Emerging markets in Asia-Pacific regions show particularly strong growth, driven by expanding biopharmaceutical sectors.

Environmental and safety considerations for handling UTP Trisodium Salt Dihydrate follow standard laboratory protocols. While not classified as hazardous, proper PPE (personal protective equipment) including gloves and lab coats is recommended. Disposal should comply with institutional guidelines for organic compounds, with particular attention to preventing aquatic environmental contamination.

Future research directions for Uridine-5'-triphosphate Trisodium Salt may explore its potential in neurological disorders treatment, given uridine's documented neuroprotective effects. Additionally, its incorporation into artificial cell systems and synthetic biology constructs presents exciting possibilities for bioengineers. The compound's compatibility with CRISPR-Cas9 systems also warrants further investigation for genome editing applications.

For researchers sourcing CAS 116295-90-0, verification of certificates of analysis (CoA) and material safety data sheets (MSDS) remains essential. Reputable suppliers typically provide batch-specific documentation including HPLC chromatograms and mass spectrometry data. Recent industry trends emphasize blockchain-tracked supply chains to ensure authenticity of nucleotide reagents.

In conclusion, Uridine-5'-triphosphate Trisodium Salt Dihydrate represents a cornerstone molecule bridging fundamental research and applied biotechnology. Its versatility across molecular biology, drug discovery, and diagnostic development ensures sustained relevance in an era of rapid biomedical innovation. As nucleotide therapeutics gain momentum, this compound's strategic importance will likely continue to grow in both academic and industrial settings.

• 19817-92-6(Uridine triphosphate trisodium salt)
• 63-39-8(Uridine 5'-triphosphate)
• 59985-21-6(Diquafosol)
• 285978-18-9(Uridine triphosphate-)
• 211427-08-6(Diquafosol tetrasodium)
• 74674-72-9(Uridine 5'-(tetrahydrogen triphosphate), sodium salt (1:))
• 60102-52-5(2,4(1H,3H)-Pyrimidinedione,1-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-b-D-arabinofuranosyl]-)
• 10003-94-8(Uridine5'-(pentahydrogen tetraphosphate) (9CI))
• 58658-46-1(Uridine 5'-(hexahydrogen pentaphosphate))
• 876068-85-8(Uridine 5'-(tetrahydrogen triphosphate), 3-methyl-)