• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 3. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Introduction to b-Alanine-2,2,3,3-d4 (CAS No. 116173-67-2)

b-Alanine-2,2,3,3-d4 is a deuterated derivative of b-alanine, a non-proteinogenic amino acid that plays a crucial role in various biological processes. The compound is characterized by the substitution of four hydrogen atoms with deuterium atoms at the 2, 2', 3, and 3' positions, making it a valuable tool in biochemical research and pharmaceutical development. With a CAS number of 116173-67-2, this compound has garnered significant attention due to its unique properties and potential applications.

The significance of b-alanine in biological systems cannot be overstated. It is a key component of gamma-aminobutyric acid (GABA), a neurotransmitter that plays a vital role in inhibitory neural signaling. Additionally, b-alanine is essential for the synthesis of carnosine, an antioxidant peptide found in muscle tissues that helps mitigate oxidative stress and improve exercise performance. The deuterated version, b-Alanine-2,2,3,3-d4, offers researchers a means to study the metabolic pathways and interactions of b-alanine with greater precision.

In recent years, the demand for stable isotope-labeled compounds has surged due to their utility in metabolic studies and drug development. b-Alanine-2,2,3,3-d4 provides a non-radioactive alternative for tracing metabolic pathways and understanding the kinetics of amino acid metabolism. This compound is particularly useful in mass spectrometry-based assays, where isotopic labeling enhances sensitivity and specificity. The use of deuterated compounds like b-Alanine-2,2,3,3-d4 allows for the detection of subtle changes in metabolic fluxes that might be overlooked with traditional labeled analogs.

One of the most compelling applications of b-Alanine-2,2,3,3-d4 is in the field of drug discovery and development. By incorporating deuterium atoms into biomolecules, researchers can modulate the pharmacokinetic properties of drugs. Deuterium labeling has been shown to increase the metabolic stability of pharmaceuticals, thereby extending their half-life and improving therapeutic efficacy. For instance, studies have demonstrated that deuterium-labeled GABA analogs exhibit enhanced binding affinity and reduced degradation rates compared to their non-deuterated counterparts. This has opened up new avenues for developing more effective anxiolytic agents.

The synthesis of b-Alanine-2,2,3,3-d4 presents unique challenges due to the need for precise isotopic labeling. Advanced chemical techniques such as isotopic exchange reactions and catalytic hydrogenation are employed to achieve the desired deuterium incorporation. These methods require stringent control over reaction conditions to ensure high isotopic purity and yield. The growing interest in deuterated compounds has led to significant advancements in synthetic methodologies, making it increasingly feasible to produce complex labeled molecules like b-Alanine-2,2,3,3-d4 on a scalable basis.

Recent research has also highlighted the potential of b-Alanine-2,2,3,3-d4 in studying aging-related processes. Carnosine levels have been observed to decline with age, correlating with increased oxidative stress and cellular dysfunction. By using labeled b-alanine, researchers can investigate how changes in carnosine levels impact aging phenotypes and explore potential interventions to counteract age-related decline. This line of inquiry has significant implications for developing interventions aimed at promoting healthy aging.

The use of b-Alanine-2,2,3,3-d4 extends beyond basic research into applied sciences as well. In nutrition science， this compound is being explored as a potential supplement for enhancing physical performance and cognitive function. While more studies are needed to fully understand its effects， preliminary evidence suggests that b-alanine supplementation can improve muscle endurance and mental focus by increasing carnosine levels in tissues. This has sparked interest among athletes and health enthusiasts looking for natural ways to boost their performance.

From a regulatory perspective， the use of deuterated compounds like b-Alanine-2， 23， 33-d4 requires careful consideration。 Regulatory agencies such as the FDA have established guidelines for the approval of drugs containing stable isotopes。 These guidelines ensure that labeled compounds are safe for human use and that their isotopic modifications do not alter their pharmacological properties adversely。 The growing acceptance of deuterated drugs has created a favorable environment for further research and development in this area。

The future prospects for b-Alanine-23， 33-d4 are promising， with ongoing research uncovering new applications across multiple disciplines。 As analytical techniques continue to evolve， the ability to detect and analyze isotopically labeled compounds will only improve， further expanding their utility in scientific inquiry。 Whether it's advancing our understanding of basic biological processes or developing novel therapeutic agents， compounds like b-Alanine-23， 33-d4 are poised to play a pivotal role in shaping the future of science。

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• 64700-13-6(b-Alanine-3,3-t2 (9CI))
• 2679-14-3(N-Methyl-b-alanine)
• 285978-07-6(b-Alanine-13C3,15N)
• 39748-53-3(b-Alanine, potassium salt (1:1))
• 16690-93-0(b-Alanine, sodium salt (1:1))
• 36321-40-1(b-Alanine, calcium salt (2:1))
• 14405-06-2(b-Alanine-3-14C (6CI,8CI,9CI))
• 107-95-9(β-Alanine)
• 88606-93-3(β-Alanine, N-methyl-, monoammonium salt (9CI))