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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

b-Alanine-13C3,15N (CAS No. 285978-07-6): A Comprehensive Overview

b-Alanine-13C3,15N (CAS No. 285978-07-6) is a stable isotope-labeled derivative of b-alanine, a non-essential amino acid that plays a crucial role in various biological processes. This compound is extensively used in metabolic studies, drug development, and clinical research due to its unique properties and the ability to trace metabolic pathways without altering the biological activity of the parent molecule.

The chemical structure of b-Alanine-13C3,15N consists of a carboxyl group, an amino group, and a three-carbon backbone, where the carbon atoms are labeled with the stable isotope 13C and the nitrogen atom is labeled with 15N. This labeling allows for precise tracking of the compound's fate in biological systems using techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy.

In recent years, the use of stable isotope-labeled compounds like b-Alanine-13C3,15N has gained significant attention in the field of metabolomics. Metabolomics involves the comprehensive analysis of small molecules (metabolites) in biological systems and provides valuable insights into cellular metabolism, disease states, and drug efficacy. The stable isotopes in b-Alanine-13C3,15N enable researchers to distinguish between endogenous and exogenous sources of b-alanine, thereby facilitating a more accurate understanding of metabolic pathways.

One of the key applications of b-Alanine-13C3,15N is in the study of muscle metabolism. b-Alanine is a precursor to carnosine, a dipeptide that plays a critical role in buffering intracellular pH during intense exercise. By using b-Alanine-13C3,15N, researchers can trace the synthesis and degradation of carnosine in muscle tissue, providing insights into how exercise and dietary interventions affect muscle function and performance.

In addition to its role in muscle metabolism, b-Alanine-13C3,15N has been utilized in cancer research. Cancer cells often exhibit altered metabolic profiles compared to normal cells, and understanding these changes can lead to new therapeutic strategies. Studies have shown that cancer cells can upregulate the uptake and utilization of b-alanine for energy production and biosynthesis. By using b-Alanine-13C3,15N, researchers can track these metabolic changes and identify potential targets for intervention.

The pharmaceutical industry also benefits from the use of stable isotope-labeled compounds like b-Alanine-13C3,15N. In drug development, these compounds are used to study drug metabolism and pharmacokinetics (PK). By incorporating stable isotopes into drug molecules or their precursors, researchers can track the absorption, distribution, metabolism, and excretion (ADME) properties of drugs with high precision. This information is crucial for optimizing drug formulations and dosing regimens.

Clinical trials often employ stable isotope-labeled compounds to evaluate the efficacy and safety of new drugs. For example, in phase I trials, where safety and dosing are primary concerns, b-Alanine-13C3,15N can be used to monitor drug metabolism in real-time. This approach provides valuable data on how the body processes the drug and helps identify potential adverse effects early in the development process.

The use of stable isotopes like those found in b-Alanine-13C3,15N also extends to environmental research. In this context, these compounds are used to trace the fate of pollutants in ecosystems. For instance, by labeling pollutants with stable isotopes and releasing them into controlled environments, researchers can track their movement through soil, water, and air. This information is essential for developing strategies to mitigate environmental contamination.

In summary, b-Alanine-13C3,15N (CAS No. 285978-07-6) is a versatile compound with numerous applications in biological research. Its ability to provide detailed insights into metabolic pathways makes it an invaluable tool for scientists working in metabolomics, muscle physiology, cancer biology, pharmaceutical development, and environmental science. As research continues to advance in these fields, the demand for high-quality stable isotope-labeled compounds like b-Alanine-13C3,15N is likely to grow.

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