• 1. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 2. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 3. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 4. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 5. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143

Recent Advances in the Application of 3-Bromo-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde (CAS: 1159982-08-7) in Chemical Biology and Pharmaceutical Research

The compound 3-bromo-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde (CAS: 1159982-08-7) has recently emerged as a key intermediate in the synthesis of novel bioactive molecules, particularly in the fields of oncology and infectious diseases. This heterocyclic aldehyde, featuring a pyrrolopyridine core, has garnered significant attention due to its versatile reactivity and potential as a pharmacophore. Recent studies have demonstrated its utility in the development of kinase inhibitors, antiviral agents, and other targeted therapies.

A 2023 study published in the Journal of Medicinal Chemistry highlighted the role of 3-bromo-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde in the synthesis of selective JAK2 inhibitors. The researchers utilized this compound as a crucial building block to create a series of derivatives with improved potency and selectivity profiles. The bromo substituent at the 3-position proved particularly valuable for subsequent palladium-catalyzed cross-coupling reactions, enabling rapid diversification of the molecular scaffold.

In parallel developments, several research groups have explored the antiviral potential of derivatives based on this chemical structure. A recent preprint on bioRxiv described the synthesis and evaluation of 3-bromo-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde derivatives as potential inhibitors of SARS-CoV-2 main protease. The aldehyde functionality was strategically employed in reductive amination reactions to generate a library of compounds with varying pharmacological properties.

The synthetic accessibility of 3-bromo-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde has also been improved through recent methodological advances. A 2024 publication in Organic Letters detailed a novel one-pot synthesis approach that significantly increases the yield while reducing purification steps. This development is particularly important for scaling up production for preclinical and clinical studies.

From a structural perspective, computational chemistry studies have provided insights into the molecular interactions of derivatives containing this scaffold. Molecular docking simulations have shown that the planar pyrrolopyridine system can effectively engage in π-π stacking interactions with aromatic residues in protein binding sites, while the aldehyde group serves as a versatile handle for further structural modifications.

Looking forward, the unique combination of reactivity and biological activity displayed by 3-bromo-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde suggests it will continue to play an important role in medicinal chemistry campaigns. Several pharmaceutical companies have included derivatives of this compound in their pipelines, particularly for immune-oncology applications. The coming years are likely to see additional structure-activity relationship studies and optimization efforts focused on this promising scaffold.

• 757978-33-9(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde)
• 1190313-75-7(5-BroMo-4-Methyl-7-azaindole-3-carbaldehyde)
• 1082040-66-1(3-BroMo-4,5-diMethyl-7-azaindole)
• 1190310-82-7(methyl 3-bromo-1H-pyrrolo[2,3-b]pyridine-4-carboxylate)
• 1000340-35-1(4-Bromo-1H-pyrrolo[2,3-B]pyridine-3-carbaldehyde)
• 802264-75-1(3-Bromo-4-methyl-1H-pyrrolo[2,3-b]pyridine)
• 1190317-92-0(3-BroMo-7-azaindole-5-carbaldehyde)
• 944956-08-5(3-Bromo-4-phenyl-1H-pyrrolo[2,3-b]pyridine)
• 1190314-17-0(3-Bromo-1h-pyrrolo[2,3-b]pyridine-4-carboxylic acid)
• 1000340-54-4(3-Bromo-1H-pyrrolo[2,3-b]pyridine-4-carbonitrile)