Cas no 115321-98-7 (6a-Methyl Prednisone 21-Acetate)

6a-Methyl Prednisone 21-Acetate is a synthetic corticosteroid derivative with notable anti-inflammatory and immunosuppressive properties. Its structural modification, featuring a 6a-methyl group and a 21-acetate moiety, enhances metabolic stability and potency compared to unmodified prednisone derivatives. This compound is primarily utilized in research settings to study glucocorticoid receptor interactions and corticosteroid metabolism. The 21-acetate ester improves lipophilicity, facilitating cellular uptake, while the 6a-methyl group contributes to prolonged biological activity by reducing enzymatic degradation. These characteristics make it a valuable tool for investigating steroid pharmacology and developing refined therapeutic agents with optimized efficacy and pharmacokinetic profiles.
6a-Methyl Prednisone 21-Acetate structure
115321-98-7 structure
Product Name:6a-Methyl Prednisone 21-Acetate
CAS No:115321-98-7
MF:C24H30O6
MW:414.491407871246
CID:130725
Update Time:2025-09-28

6a-Methyl Prednisone 21-Acetate Chemical and Physical Properties

Names and Identifiers

    • Pregna-1,4-diene-3,11,20-trione,21-(acetyloxy)-17-hydroxy-6-methyl-, (6a)-
    • 6α-Methyl Prednisone 21-Acetate
    • 6a-Methylprednisone 21-Acetate
    • [2-[(6S,8S,9S,10R,13S,14S,17R)-17-hydroxy-6,10,13-trimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
    • 6α-Methyl Prednisone
    • 17,21-Dihydroxy-6
    • 6Alpha-Methyl Prednisone 21-Acetate
    • A)-21-(acetyloxy)-17-hydroxy-6-methylpregna-1,4-diene-3,11,20-trione
    • A-Methyl Prednisone 21-Acetate
    • A-methylpregna-1,4-diene-3,11,20-trione 21-Acetate
    • 17,21-Dihydroxy-6a-methylpregna-1,4-diene-3,11,20-trione 21-Acetate
    • (6a)-21-(acetyloxy)-17-hydroxy-6-methylpregna-1,4-diene-3,11,20-trione
    • 6a-Methyl Prednisone 21-Acetate
    • Inchi： 1S/C24H30O6/c1-13-9-16-17-6-8-24(29,20(28)12-30-14(2)25)23(17,4)11-19(27)21(16)22(3)7-5-15(26)10-18(13)22/h5,7,10,13,16-17,21,29H,6,8-9,11-12H2,1-4H3/t13-,16-,17-,21+,22-,23-,24-/m0/s1
    • InChI Key： KMSUNGHJCVAKKC-CEDBDYPOSA-N
    • SMILES： O[C@]1(C(COC(C)=O)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(C=C[C@]4(C)[C@H]3C(C[C@@]21C)=O)=O

Computed Properties

  • Exact Mass: 414.20400

Experimental Properties

  • PSA: 97.74000
  • LogP: 2.58260

6a-Methyl Prednisone 21-Acetate Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
M326035-1mg
6a-Methyl Prednisone 21-Acetate
 115321-98-7
1mg
 $ 187.00 2023-04-17
TRC
M326035-2mg
6a-Methyl Prednisone 21-Acetate
 115321-98-7
2mg
 $ 351.00 2023-04-17
TRC
M326035-5mg
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5mg
 $ 809.00 2023-09-07
TRC
M326035-10mg
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 115321-98-7
10mg
 $ 1454.00 2023-09-07
A2B Chem LLC
AA21312-1mg
Pregna-1,4-diene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-6-methyl-, (6α)-
 115321-98-7
1mg
 $770.00 2024-01-04
A2B Chem LLC
AA21312-2mg
Pregna-1,4-diene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-6-methyl-, (6α)-
 115321-98-7
2mg
 $1164.00 2024-01-04
A2B Chem LLC
AA21312-5mg
Pregna-1,4-diene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-6-methyl-, (6α)-
 115321-98-7
5mg
 $895.00 2024-04-20
A2B Chem LLC
AA21312-10mg
Pregna-1,4-diene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-6-methyl-, (6α)-
 115321-98-7
10mg
 $1514.00 2024-04-20
SHENG KE LU SI SHENG WU JI SHU
sc-207146-1mg
6α-Methylprednisone 21-Acetate,
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 ￥2482.00 2023-09-05
SHENG KE LU SI SHENG WU JI SHU
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6a-Methyl Prednisone 21-Acetate Related Literature

Related Categories

Additional information on 6a-Methyl Prednisone 21-Acetate

Comprehensive Overview of 6a-Methyl Prednisone 21-Acetate (CAS No. 115321-98-7): Properties, Applications, and Research Insights

6a-Methyl Prednisone 21-Acetate (CAS No. 115321-98-7) is a synthetic corticosteroid derivative with significant pharmacological relevance. This compound, structurally related to prednisone, features a 6a-methyl modification and a 21-acetate ester group, enhancing its stability and bioavailability. Researchers and pharmaceutical developers frequently explore its potential in anti-inflammatory and immunomodulatory therapies, aligning with current trends in precision medicine and targeted drug delivery.

The growing interest in 6a-Methyl Prednisone 21-Acetate is evident from its frequent mentions in academic literature and patent filings. Users searching for "corticosteroid derivatives" or "anti-inflammatory steroid analogs" often encounter this compound due to its unique structural attributes. Its CAS No. 115321-98-7 serves as a critical identifier in chemical databases, ensuring accurate retrieval for regulatory or research purposes.

Recent advancements in synthetic chemistry have spotlighted 6a-Methyl Prednisone 21-Acetate as a candidate for optimizing glucocorticoid receptor affinity. Studies suggest that the 6a-methyl group may reduce metabolic degradation, while the 21-acetate moiety improves membrane permeability—a combination addressing key challenges in steroid therapeutics. These features resonate with trending queries like "long-acting corticosteroids" and "steroid prodrug design."

From an industrial perspective, CAS 115321-98-7 is manufactured under stringent GMP conditions to ensure purity for preclinical studies. Analytical techniques such as HPLC and NMR confirm its identity, meeting global pharmacopeial standards. Discussions on platforms like ResearchGate often highlight its role in "structure-activity relationship (SAR) studies," reflecting the scientific community's focus on rational drug design.

Environmental and safety profiles of 6a-Methyl Prednisone 21-Acetate are rigorously evaluated, with data available in REACH dossiers. Unlike conventional steroids, its optimized structure may reduce ecological persistence—a topic gaining traction in "green pharmaceutical chemistry" forums. This aligns with ESG (Environmental, Social, and Governance) trends driving modern pharmaceutical R&D.

In conclusion, 6a-Methyl Prednisone 21-Acetate (CAS No. 115321-98-7) exemplifies innovation in steroid pharmacology. Its dual modifications address both efficacy and sustainability concerns, making it a compelling subject for researchers investigating "next-generation anti-inflammatory agents." As demand for targeted therapies grows, this compound’s scientific and commercial relevance will likely expand further.

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