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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines Pyrrolidine-2-ones
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines Pyrrolidones Pyrrolidine-2-ones

Comprehensive Overview of 5-(Aminomethyl)pyrrolidin-2-one Hydrochloride (CAS No. 115307-13-6): Properties, Applications, and Industry Insights

5-(Aminomethyl)pyrrolidin-2-one hydrochloride (CAS No. 115307-13-6) is a specialized organic compound gaining traction in pharmaceutical and biochemical research due to its unique structural features. This pyrrolidinone derivative combines a five-membered lactam ring with an aminomethyl functional group, making it a versatile intermediate in drug discovery. The hydrochloride salt form enhances its solubility and stability, addressing formulation challenges in modern therapeutics.

Recent studies highlight the compound's role as a precursor for nootropic agents and neurological disorder treatments, aligning with growing interest in cognitive enhancement solutions. Its molecular structure allows for blood-brain barrier penetration, a hot topic in neuropharmacology research. Industry data shows a 42% increase in patent filings involving pyrrolidinone scaffolds since 2020, reflecting its importance in CNS-targeted drug development.

The synthesis of 5-(aminomethyl)pyrrolidin-2-one hydrochloride typically involves reductive amination of corresponding carbonyl precursors, with optimized routes achieving >85% yield. Analytical characterization via HPLC-MS and NMR spectroscopy confirms the high purity (>98%) required for pharmaceutical applications. Researchers particularly value its chiral center for developing stereospecific bioactive molecules, a key focus area in precision medicine development.

In formulation science, the compound's hygroscopic nature necessitates controlled humidity packaging, while its aqueous solubility (≥50 mg/mL at pH 3-5) makes it suitable for injectable preparations. Stability studies indicate satisfactory shelf life under standard storage conditions, though lyophilized formulations show superior long-term performance – a crucial consideration for biopharmaceutical logistics professionals.

Emerging applications include its use as a ligand in catalytic systems for asymmetric synthesis, where the secondary amine moiety demonstrates notable chelating properties. This aligns with the pharmaceutical industry's push toward green chemistry principles, reducing heavy metal catalyst dependence. Computational modeling suggests potential in enzyme inhibition, particularly for protease targets relevant to viral infections.

Quality control protocols for CAS 115307-13-6 emphasize residual solvent analysis and heavy metal screening per ICH guidelines. The compound's thermal stability (decomposition >220°C) allows for various sterilization methods, addressing GMP manufacturing requirements. Recent analytical advancements enable detection of optical isomers at ≤0.1% levels, critical for chiral drug development programs.

Market analysts project 6.8% CAGR for pyrrolidinone-based intermediates through 2028, driven by demand for neurological therapeutics and anti-inflammatory agents. The compound's structure-activity relationship (SAR) profile shows promise for GPCR-targeted drugs, particularly in neurodegenerative disease research. Current investigations explore its potential as a bioisostere for proline derivatives in peptide mimetics.

From a regulatory perspective, 5-(aminomethyl)pyrrolidin-2-one hydrochloride requires proper REACH registration for European markets, with safety data confirming low acute toxicity (LD50 >2000 mg/kg oral, rat). Environmental fate studies demonstrate ready biodegradability, supporting its selection in sustainable pharmaceutical development initiatives. Proper handling involves standard laboratory PPE, with no unusual disposal requirements.

Innovative delivery systems incorporating this compound include nanoparticle carriers and transdermal patches, leveraging its molecular weight (150.6 g/mol) and logP value (-1.2) for optimized biodistribution. These developments respond to growing demand for non-invasive administration methods in chronic disease management. Comparative studies show advantages over similar cyclic amine building blocks in terms of metabolic stability.

The scientific community continues exploring structure-modification strategies to enhance the compound's pharmacokinetic profile. Recent publications demonstrate successful N-functionalization approaches that improve target binding affinity while maintaining favorable ADME properties. These advancements position CAS 115307-13-6 as a valuable tool in fragment-based drug design paradigms.

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