• 1. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 2. An apparatus for testing water by measurement of its electrical conductivity
  Analyst, 1912,37, 538-543
• 3. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126
• 4. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 5. An approach for correlating the structural and electrical properties of Zr4+-modified SrBi4Ti4O15/SBT ceramic
  Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Hydroxybenzoic acid derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Hydroxybenzoic acid derivatives

Professional Introduction to 2,4-Dihydroxy-3-methylbenzohydrazide (CAS No. 1142211-15-1)

2,4-Dihydroxy-3-methylbenzohydrazide, identified by its Chemical Abstracts Service (CAS) number 1142211-15-1, is a heterocyclic organic compound that has garnered significant attention in the field of pharmaceutical and biochemical research. This compound, characterized by its benzohydrazide moiety and hydroxyl substituents, exhibits a unique structural framework that positions it as a versatile intermediate in synthetic chemistry and a potential candidate for various biological applications.

The molecular structure of 2,4-Dihydroxy-3-methylbenzohydrazide consists of a benzene ring substituted with two hydroxyl groups at the 2- and 4-positions, a methyl group at the 3-position, and a hydrazide functional group. This specific arrangement imparts distinct chemical properties, including reactivity with nucleophiles and electrophiles, making it a valuable building block for the synthesis of more complex molecules. The presence of hydroxyl groups enhances its solubility in polar solvents, while the hydrazide moiety allows for further functionalization via condensation reactions.

In recent years, 2,4-Dihydroxy-3-methylbenzohydrazide has been explored in several cutting-edge research areas within pharmaceutical chemistry. One of the most promising applications lies in its role as a precursor in the synthesis of bioactive molecules. For instance, studies have demonstrated its utility in constructing Schiff bases, which are widely recognized for their pharmacological properties. These derivatives have shown potential in modulating enzyme activity and interacting with biological targets, making them attractive candidates for drug development.

Moreover, the compound has been investigated for its potential antimicrobial and antioxidant properties. Research indicates that derivatives of 2,4-Dihydroxy-3-methylbenzohydrazide can exhibit inhibitory effects against various microbial pathogens, including bacteria and fungi. This is attributed to their ability to disrupt essential metabolic pathways or membrane integrity in these organisms. Additionally, the hydroxyl groups in the molecule contribute to its antioxidant activity by scavenging free radicals and reducing oxidative stress.

The pharmacological significance of 2,4-Dihydroxy-3-methylbenzohydrazide extends to its potential role in addressing inflammatory conditions. Emerging research suggests that certain derivatives of this compound may modulate inflammatory responses by inhibiting key pro-inflammatory cytokines and enzymes. This makes it a promising candidate for developing novel anti-inflammatory agents that could offer therapeutic benefits in chronic inflammatory diseases.

Another area where 2,4-Dihydroxy-3-methylbenzohydrazide has shown promise is in the field of neurochemistry. Preliminary studies have indicated that derivatives of this compound may interact with central nervous system (CNS) receptors, potentially leading to applications in treating neurological disorders. The ability of these derivatives to cross the blood-brain barrier remains an active area of investigation, but initial findings are encouraging.

The synthetic chemistry of 2,4-Dihydroxy-3-methylbenzohydrazide also presents interesting challenges and opportunities. Researchers have developed efficient synthetic routes to this compound using various starting materials and catalysts. These methods often involve multi-step processes that highlight the compound's versatility as an intermediate. Advances in green chemistry have further refined these synthetic pathways, making them more sustainable and environmentally friendly.

In conclusion, 2,4-Dihydroxy-3-methylbenzohydrazide (CAS No. 1142211-15-1) is a multifaceted compound with significant potential in pharmaceutical research. Its unique structural features enable diverse applications in drug synthesis, antimicrobial agents, antioxidant formulations, anti-inflammatory treatments, and neurochemical investigations. As research continues to uncover new biological activities and synthetic methodologies for this compound, its importance in medicinal chemistry is likely to grow even further.

• 13221-86-8(2,4-Dihydroxybenzohydrazide)
• 23647-78-1(Benzoic acid,2-hydroxy-, 2-(2-hydroxybenzoyl)hydrazide)
• 1010-85-1(Benzoic acid,2-hydroxy-, 2-formylhydrazide)
• 936-02-7(benzoylhydrazine, O-hydroxy)
• 392741-20-7(Benzoic acid,2,4-dihydroxy-, 2-acetylhydrazide)
• 20349-50-2(N'-acetyl-2-hydroxybenzohydrazide)
• 30991-42-5(2-Hydroxy-3-methylbenzohydrazide)
• 15791-90-9(2,5-Dihydroxybenzohydrazide)
• 41697-08-9(2-Hydroxy-4-methoxybenzenecarbohydrazide)
• 5341-58-2(3-hydroxynaphthalene-2-carbohydrazide)