• 1. High-resolution two-field nuclear magnetic resonance spectroscopy
  Samuel F. Cousin,Cyril Charlier,Pavel Kade?ávek,Thorsten Marquardsen,Jean-Max Tyburn,Pierre-Alain Bovier,Simone Ulzega,Thomas Speck,Dirk Wilhelm,Frank Engelke,Werner Maas,Dimitrios Sakellariou,Geoffrey Bodenhausen,Philippe Pelupessy,Fabien Ferrage Phys. Chem. Chem. Phys. 2016 18 33187

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Comprehensive Introduction to Glycine-1-13C,15N (CAS No. 112898-03-0): Applications and Analytical Insights

Glycine-1-13C,15N (CAS No. 112898-03-0) is a stable isotope-labeled derivative of the simplest amino acid, glycine. This compound is widely utilized in nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), and metabolic research due to its unique isotopic enrichment. The incorporation of 13C at the 1-position and 15N in the amino group enhances its utility as a tracer in biochemical and pharmaceutical studies. Researchers increasingly rely on isotope-labeled glycine to investigate metabolic pathways, protein synthesis, and neurotransmitter dynamics, aligning with the growing demand for precision medicine and personalized therapeutics.

In the context of drug discovery, Glycine-1-13C,15N serves as a critical tool for elucidating mechanisms of action and optimizing pharmacokinetics. Its applications extend to neurodegenerative disease research, where it aids in studying glycine-mediated neurotransmission. Recent trends highlight its role in gut microbiome studies, as glycine metabolism influences microbial-host interactions—a topic gaining traction in probiotic and functional food research. The compound’s stability and low toxicity make it suitable for in vivo labeling experiments, addressing key questions in metabolic flux analysis.

From an analytical perspective, Glycine-1-13C,15N is indispensable for quantitative proteomics and stable isotope-resolved metabolomics (SIRM). Its use in LC-MS and GC-MS workflows improves data accuracy by minimizing background interference. Industry professionals frequently search for "13C-labeled amino acid suppliers" or "isotopic standards for metabolomics," reflecting the compound’s commercial relevance. Furthermore, its compatibility with high-resolution mass spectrometers aligns with the shift toward high-throughput omics technologies.

Environmental scientists also employ Glycine-1-13C,15N to trace nitrogen cycling in ecosystems, a hot topic in climate change mitigation research. The compound’s dual-labeling design allows simultaneous tracking of carbon and nitrogen atoms, answering pressing questions about soil health and agricultural sustainability. This multidisciplinary utility underscores its value across life sciences, agriculture, and environmental monitoring.

Quality control of Glycine-1-13C,15N adheres to stringent ISO-certified protocols, ensuring >98% isotopic purity—a key concern for researchers seeking reproducible results. FAQs like "how to store 13C-labeled compounds" or "best practices for glycine isotope experiments" emphasize user needs for stability and handling guidelines. As AI-driven drug design and machine learning in metabolomics advance, the demand for high-fidelity labeled compounds like Glycine-1-13C,15N will continue to rise, solidifying its role in next-generation scientific workflows.

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