• 1. An investigation of surface properties, local elastic modulus and interaction with simulated pulmonary surfactant of surface modified inhalable voriconazole dry powders using atomic force microscopy
  Michael Kappl,Paul M. Young,Daniela Traini,Sanyog Jain RSC Adv., 2016,6, 25789-25798
• 2. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 3. Alternative synthesis of the anti-baldness compound RU58841?
  RSC Adv., 2014,4, 14143-14148
• 4. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
• 5. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives 2-halopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines 2-halopyridines

Professional Introduction to 2-Bromo-6-(methoxymethyl)pyridine (CAS No. 112575-15-2)

2-Bromo-6-(methoxymethyl)pyridine, with the chemical formula C?H?BrNO?, is a significant compound in the field of pharmaceutical and agrochemical research. This compound serves as a versatile intermediate in the synthesis of various biologically active molecules. Its unique structural features, including a bromine substituent and a methoxymethyl group, make it a valuable building block for medicinal chemists and synthetic organic chemists. The CAS No. 112575-15-2 uniquely identifies this substance and ensures consistency in its documentation and use across scientific communities.

The bromo and methoxymethyl functional groups in 2-Bromo-6-(methoxymethyl)pyridine contribute to its reactivity, allowing for further functionalization through various chemical transformations. These properties have made it a popular choice in the development of novel pharmaceuticals, particularly in the synthesis of kinase inhibitors, antiviral agents, and other therapeutic compounds. Recent advancements in drug discovery have highlighted the importance of such intermediates in streamlining synthetic routes and improving yields.

In recent years, there has been growing interest in the use of heterocyclic compounds like pyridine derivatives in medicinal chemistry. Pyridine-based scaffolds are known for their ability to interact with biological targets effectively, making them integral to many drug molecules. The methoxymethyl group in 2-Bromo-6-(methoxymethyl)pyridine provides an additional point of modification, enabling chemists to explore diverse structural motifs. This flexibility has been exploited in the design of compounds targeting specific disease pathways.

One notable application of 2-Bromo-6-(methoxymethyl)pyridine is in the synthesis of small-molecule inhibitors for protein kinases. Protein kinases are critical enzymes involved in numerous cellular processes, and their dysregulation is associated with various diseases, including cancer. By modifying the pyridine core with bromo and methoxymethyl groups, researchers have been able to develop potent inhibitors with improved selectivity and efficacy. For instance, recent studies have demonstrated the use of this compound in generating inhibitors that selectively target specific kinases involved in tumor growth and progression.

TheCAS No. 112575-15-2 ensures that researchers can reliably source this compound from reputable suppliers while maintaining compliance with regulatory standards. This is particularly important in academic and industrial settings where precision and reproducibility are paramount. The compound's stability under various storage conditions also enhances its utility as an intermediate, allowing for long-term projects without significant degradation.

In addition to its role in kinase inhibition, 2-Bromo-6-(methoxymethyl)pyridine has been explored in the development of antiviral agents. The pyridine ring's ability to mimic natural nucleobases has been leveraged to design inhibitors that disrupt viral replication cycles. Researchers have utilized thebromo andmethoxymethyl groups to optimize binding interactions with viral proteins, leading to the discovery of promising candidates for further development.

The synthesis of 2-Bromo-6-(methoxymethyl)pyridine typically involves multi-step organic reactions starting from readily available precursors. The introduction of the bromine substituent at the 2-position can be achieved through electrophilic aromatic substitution reactions, while the methoxymethyl group is often incorporated via nucleophilic addition or etherification reactions. These synthetic strategies highlight the compound's versatility as a synthetic intermediate.

The growing body of research utilizing 2-Bromo-6-(methoxymethyl)pyridine underscores its importance in modern drug discovery. As new therapeutic targets are identified and characterized, compounds derived from this intermediate will continue to play a crucial role in developing innovative treatments. The continued exploration of its applications will likely uncover additional uses beyond those currently recognized.

In conclusion, 2-Bromo-6-(methoxymethyl)pyridine (CAS No. 112575-15-2) is a valuable compound with broad applications in pharmaceutical research. Its unique structural features enable diverse chemical modifications, making it an essential tool for medicinal chemists seeking to develop novel therapeutic agents. The ongoing research into its applications highlights its significance as a building block for future generations of drugs.

• 26218-75-7(Methyl 6-bromopyridine-2-carboxylate)
• 33674-96-3((6-Bromopyridin-2-yl)methanol)
• 588727-62-2(2,2'-BIPYRIDINE, 6-[[(6-BROMO-2-PYRIDINYL)METHOXY]METHYL]-6'-METHYL-)
• 399031-16-4(Pyridine, 2-bromo-6-(phenoxymethyl)-)
• 588727-60-0(PYRIDINE, 2,2'-[OXYBIS(METHYLENE)]BIS[6-BROMO-)
• 34199-87-6(2-Bromo-6-(1,3-dioxolan-2-yl)pyridine)
• 147133-46-8((6-Bromopyridin-2-yl)methyl acetate)
• 128507-76-6(Pyridine, 2-bromo-6-(dimethoxymethyl)-)
• 122918-26-7(2-Pyridinecarboximidic acid, 6-bromo-, methyl ester)
• 399031-17-5(Pyridine, 2-bromo-6-[(1-methylethoxy)methyl]-)