• 1. Aggregation, pretransitional behavior, and optical properties in the isotropic phase of lyotropic chromonic liquid crystals studied in high magnetic fields
  Tanya Ostapenko,Peter J. Collings,Samuel N. Sprunt,J. T. Gleeson Soft Matter, 2013,9, 9487-9498
• 2. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
• 3. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 4. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
• 5. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acids and conjugates Halogenated fatty acids

Comprehensive Guide to 4-Fluoro-2-hydroxybutanoic Acid (CAS No. 112505-18-7): Properties, Applications, and Research Insights

4-Fluoro-2-hydroxybutanoic acid (CAS No. 112505-18-7) is a fluorinated derivative of hydroxybutanoic acid, gaining attention in pharmaceutical and biochemical research due to its unique structural properties. This compound, characterized by a fluoro substitution at the fourth carbon and a hydroxyl group at the second position, serves as a versatile intermediate in organic synthesis. Its molecular formula, C₄H₇FO₃, and chiral center make it valuable for designing bioactive molecules, particularly in drug discovery and metabolic studies.

Recent trends highlight growing interest in fluorinated organic compounds, driven by their enhanced stability and bioavailability. Researchers frequently search for "4-Fluoro-2-hydroxybutanoic acid synthesis" or "CAS 112505-18-7 applications," reflecting demand for scalable production methods and novel uses. The compound’s role in peptide modification and enzyme inhibition studies aligns with current focuses on targeted therapies and precision medicine. Its compatibility with green chemistry principles also appeals to industries prioritizing sustainable practices.

From a technical perspective, 4-Fluoro-2-hydroxybutanoic acid exhibits a melting point range of 80–85°C and solubility in polar solvents like water and ethanol. These properties facilitate its incorporation into aqueous reaction systems, a key advantage for bioconjugation and prodrug development. Analytical techniques such as NMR spectroscopy and HPLC-MS are commonly employed to verify its purity, with impurities often monitored due to their impact on downstream applications.

Innovative applications of CAS 112505-18-7 include its use as a building block for fluorinated amino acid analogs, which mimic natural metabolites to study cellular pathways. This aligns with rising searches for "fluorine in drug design" and "metabolic engineering tools." Additionally, its potential in biodegradable polymer research addresses environmental concerns, linking to trending topics like "eco-friendly biomaterials."

Quality control protocols for 4-Fluoro-2-hydroxybutanoic acid emphasize strict storage conditions (2–8°C under inert atmosphere) to prevent degradation. Suppliers often provide technical data sheets detailing residual solvent levels and enantiomeric purity, critical for compliance with pharmaceutical standards. Regulatory frameworks like ICH guidelines and REACH further govern its commercial distribution.

Future research directions may explore CAS 112505-18-7 in catalysis or as a precursor for PET tracer development, areas gaining traction in academic literature. Collaborative studies between synthetic chemists and biologists could unlock its full potential, answering frequent queries like "how to modify fluorinated acids for better bioavailability." As industries seek alternatives to traditional compounds, this fluorinated hydroxy acid stands out for its adaptability and scientific relevance.

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