• 1. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 2. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 3. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 4. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyridines Pyrrolopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyridines

5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine: A Comprehensive Overview

5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine, also known by its CAS number 1111638-02-8, is a heterocyclic aromatic compound with significant potential in various fields of chemistry and materials science. This compound belongs to the class of pyrrolopyridines, which are fused bicyclic structures combining a pyrrole and a pyridine ring. The presence of a bromine atom at the 5-position and a methyl group at the 2-position introduces unique electronic and steric properties, making it an interesting subject for both fundamental research and practical applications.

The synthesis of 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine typically involves multi-step organic reactions. Recent advancements in catalytic methods have enabled more efficient pathways for constructing such fused heterocycles. For instance, researchers have employed transition metal-catalyzed coupling reactions to assemble the pyrrolopyridine framework with high regioselectivity. These methods not only improve the yield but also allow for greater control over the substitution patterns, which is crucial for exploring the compound's properties.

One of the most promising applications of 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine lies in its use as a building block for advanced materials. Its aromaticity and conjugated system make it suitable for applications in organic electronics, such as in the development of new semiconducting materials or light-emitting diodes (LEDs). Recent studies have demonstrated that incorporating this compound into polymer frameworks can enhance charge transport properties, paving the way for next-generation electronic devices.

In addition to its role in materials science, 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine has shown potential in medicinal chemistry. Its structural features allow for interactions with various biological targets, making it a candidate for drug discovery efforts. For example, researchers have investigated its ability to modulate ion channels and enzyme activities, which are critical in treating neurological disorders and cancer. The bromine substituent plays a key role in these interactions by introducing electron-withdrawing effects that can influence binding affinity.

The study of 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine's photophysical properties has also garnered significant attention. Its absorption and emission characteristics make it a strong candidate for applications in optoelectronics and sensing technologies. Recent experiments have revealed that this compound exhibits strong fluorescence under certain conditions, which could be exploited for designing sensors or imaging agents.

From an environmental perspective, understanding the stability and degradation pathways of 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine is essential for assessing its safety and sustainability. Researchers have conducted detailed studies on its behavior under various environmental conditions, including exposure to light and oxidizing agents. These studies aim to ensure that its use does not pose risks to ecosystems or human health.

In conclusion, 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine, with its unique structure and versatile properties, continues to be a focal point in contemporary chemical research. Its applications span across multiple disciplines, from materials science to medicinal chemistry, underscoring its importance as a valuable compound in modern scientific endeavors.

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