• 1. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 2. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 3. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 4. Enabling chloride salts for thermal energy storage: implications of salt purity?
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• 5. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzopyrazoles Indazoles

Comprehensive Overview of 6-Bromo-1,3-dimethyl-1H-indazole (CAS No. 1095539-84-6): Properties, Applications, and Research Insights

6-Bromo-1,3-dimethyl-1H-indazole (CAS No. 1095539-84-6) is a brominated indazole derivative that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural features. As a heterocyclic compound, it serves as a versatile building block in organic synthesis, particularly in the development of small-molecule inhibitors and biologically active compounds. The presence of both bromine and dimethyl groups at specific positions enhances its reactivity, making it a valuable intermediate for medicinal chemistry applications.

Recent studies highlight the growing demand for 6-Bromo-1,3-dimethyl-1H-indazole in drug discovery programs, especially for targeting kinase pathways and GPCRs (G-protein-coupled receptors). Researchers are exploring its potential in designing anticancer agents and anti-inflammatory drugs, aligning with the current focus on precision medicine. Its CAS No. 1095539-84-6 is frequently cited in patent literature, underscoring its industrial relevance.

From a synthetic perspective, 6-Bromo-1,3-dimethyl-1H-indazole exhibits excellent stability under standard laboratory conditions, facilitating its use in cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig animations. These reactions are pivotal for constructing complex pharmacophores, a topic widely searched in AI-driven chemistry platforms. The compound’s molecular weight (239.11 g/mol) and lipophilicity (LogP ~2.5) further optimize its drug-likeness, a key parameter in ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) studies.

Environmental and regulatory trends also influence the discourse around 6-Bromo-1,3-dimethyl-1H-indazole. With increasing emphasis on green chemistry, researchers are investigating solvent-free synthetic routes and catalytic methods to minimize waste. This aligns with searches for “sustainable indazole derivatives” and “eco-friendly bromination techniques” in scientific databases.

In analytical chemistry, 6-Bromo-1,3-dimethyl-1H-indazole is characterized by techniques like HPLC, NMR, and mass spectrometry. Its distinct 1H-NMR peaks (δ 7.5–8.0 ppm for aromatic protons) and UV-Vis absorption (λ_max ~290 nm) are critical for quality control, a topic frequently queried in laboratory forums.

Future prospects for CAS No. 1095539-84-6 include explorations in covalent drug design and PROTACs (Proteolysis-Targeting Chimeras), two trending areas in biopharmaceutical innovation. As the scientific community prioritizes AI-augmented molecular modeling, this compound’s role in virtual screening workflows is expected to expand.

In summary, 6-Bromo-1,3-dimethyl-1H-indazole exemplifies the intersection of structural diversity and therapeutic potential. Its applications span from bench-scale synthesis to high-throughput screening, addressing contemporary challenges in life sciences and material engineering.

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