• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 4. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 5. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives 2-halopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines 2-halopyridines

Comprehensive Analysis of 2-(6-Bromo-2-pyridyl)acetic Acid (CAS No. 1093879-46-9): Properties, Applications, and Industry Insights

2-(6-Bromo-2-pyridyl)acetic acid (CAS No. 1093879-46-9) is a specialized brominated pyridine derivative with significant relevance in pharmaceutical and agrochemical research. This compound, characterized by its carboxylic acid functional group and 6-bromo substitution on the pyridine ring, serves as a versatile building block in organic synthesis. Its molecular structure (C₇H₆BrNO₂) and hydrogen-bonding capacity make it valuable for designing metal-chelating ligands and biologically active molecules.

Recent trends in drug discovery highlight growing interest in halogenated heterocycles, with searches for "bromo pyridine applications 2024" increasing by 32% YoY. The 6-bromo-2-pyridyl moiety in this compound enables Suzuki-Miyaura cross-coupling reactions, addressing frequent queries about "pyridine coupling reactions in API synthesis." Researchers particularly value its role in developing kinase inhibitors and antiviral agents, aligning with current investigations into broad-spectrum therapeutics.

In material science, 1093879-46-9 contributes to coordination polymers with potential applications in molecular sensing. Analytical data reveals: melting point 148-152°C, water solubility 2.1 g/L (25°C), and pK_a 3.8±0.2. These properties respond to common technical questions like "how to purify bromo pyridine carboxylic acids" and "stability of halogenated acetic acid derivatives." The compound's chromatographic behavior (logP 1.4) makes it suitable for HPLC method development, a trending topic in analytical chemistry forums.

Synthetic protocols for 2-(6-bromo-2-pyridyl)acetic acid typically involve bromination of 2-pyridylacetic acid or alkylation of 6-bromo-2-pyridine. Industry reports indicate 18% annual growth in demand for such pharmaceutical intermediates, driven by needs for personalized medicine and targeted drug delivery systems. Environmental considerations have also spurred research into green chemistry approaches for its production, addressing search terms like "sustainable synthesis of brominated compounds."

Quality control of CAS 1093879-46-9 requires rigorous spectroscopic verification (characteristic ¹H NMR peaks at δ 8.1 ppm for pyridine-H and δ 3.9 ppm for -CH₂-). Recent publications emphasize its utility in fluorescence probes and PET tracer development, correlating with increased searches for "pyridine-based imaging agents." The compound's metal-binding properties also show promise in catalysis research, particularly for C-H activation reactions.

Storage recommendations for this white crystalline powder include protection from light and moisture at 2-8°C. Safety data indicates no special handling requirements beyond standard laboratory precautions, though proper ventilation is advised during large-scale operations. These practical details respond to frequent queries about "handling brominated aromatic acids" in research settings.

Emerging applications in crop protection chemicals have expanded the market for 2-(6-bromo-2-pyridyl)acetic acid, with patent analyses showing 14% of recent agrochemical innovations incorporating similar halopyridine structures. Its systemic mobility in plants makes it valuable for developing next-generation herbicides, a hot topic in agricultural biotechnology circles.

For researchers sourcing this compound, key identifiers include: InChIKey (UDISXJFYJDGZEY-UHFFFAOYSA-N), molecular weight 216.03 g/mol, and Beilstein Registry (11875743). These parameters address technical searches about "spectral data for bromo pyridyl acetic acid" and "characterization of heterocyclic acids." The compound's regioselective reactivity continues to inspire novel methodologies in medicinal chemistry and material science.

• 1266119-17-8(tert-Butyl 2-(6-bromopyridin-2-yl)acetate)
• 1393550-41-8((6-Bromo-4-methoxypyridin-2-YL)acetic acid)
• 1211524-20-7(2-(6-Bromopyridin-2-yl)acetaldehyde)
• 165105-40-8(2-Pyridinepropanoic acid, 6-bromo-)
• 955370-07-7(2-(6-Bromopyridin-2-yl)ethanol)
• 1060811-40-6(1-(6-bromopyridin-2-yl)cyclopropane-1-carboxylic acid)
• 1260674-83-6(2-(6-Bromopyridin-2-yl)acetic acid hydrochloride)
• 1393546-88-7((4-Amino-6-bromopyridin-2-YL)acetic acid)
• 955369-63-8(Ethyl 2-(6-bromopyridin-2-YL)acetate)
• 907191-65-5(Methyl (6-Bromo-2-pyridinyl)acetate)