• 1. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 2. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 3. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 4. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 5. An amorphous lanthanum–iridium solid solution with an open structure for efficient water splitting?
  Wei Sun,Chenglong Ma,Xinlong Tian,Jianjun Liao,Ji Yang,Chengjun Ge,Weiwei Huang J. Mater. Chem. A, 2020,8, 12518-12525

Comprehensive Overview of 1-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperazine (CAS No. 1093211-85-8)

1-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperazine (CAS No. 1093211-85-8) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research. This compound features a unique benzodioxol core substituted with difluoro groups and a piperazine moiety, making it a versatile building block for drug discovery and material science applications. Its molecular structure combines aromaticity with nitrogen-based functionality, offering a balance of stability and reactivity that is highly sought after in modern synthetic chemistry.

The growing interest in 1-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperazine stems from its potential applications in central nervous system (CNS) drug development. Researchers are particularly intrigued by its structural similarity to known bioactive compounds that interact with neurotransmitter systems. The difluoro-benzodioxol component enhances metabolic stability, while the piperazine group provides excellent solubility and binding properties, making this compound a promising candidate for further pharmacological studies.

In recent years, CAS 1093211-85-8 has emerged as a key intermediate in the synthesis of novel antidepressant and antipsychotic compounds. The pharmaceutical industry's focus on developing more effective neuropsychiatric medications with fewer side effects has driven demand for such specialized building blocks. The compound's fluorinated aromatic system contributes to improved blood-brain barrier penetration, a critical factor in CNS drug design, while the piperazine tail allows for diverse structural modifications to optimize receptor binding.

From a chemical perspective, 1-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperazine demonstrates remarkable stability under various conditions, making it suitable for diverse synthetic applications. The difluoro substitution on the benzodioxol ring enhances electron-withdrawing properties without significantly increasing molecular weight, an important consideration in drug design. Meanwhile, the piperazine nitrogen atoms offer multiple sites for further functionalization, enabling the creation of compound libraries for high-throughput screening.

The synthesis of CAS 1093211-85-8 typically involves multi-step organic reactions starting from commercially available precursors. Modern synthetic approaches emphasize atom economy and green chemistry principles, reflecting the pharmaceutical industry's commitment to sustainable practices. Researchers have developed optimized routes that minimize hazardous byproducts while maintaining high yields of this valuable intermediate.

Analytical characterization of 1-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperazine employs advanced techniques including NMR spectroscopy, mass spectrometry, and HPLC purity analysis. These methods confirm the compound's structural integrity and ensure it meets the stringent quality standards required for pharmaceutical applications. The presence of both fluorine atoms and nitrogen heterocycles provides distinctive spectroscopic signatures that facilitate precise identification and quantification.

Beyond pharmaceutical applications, CAS 1093211-85-8 has shown promise in materials science, particularly in the development of specialty polymers and liquid crystals. The compound's rigid aromatic core combined with flexible amine functionality makes it an interesting monomer for creating materials with unique thermal and optical properties. Researchers are exploring its potential in organic electronics and advanced coatings, where fluorinated aromatic compounds often exhibit superior performance characteristics.

The commercial availability of 1-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperazine has expanded in recent years to meet growing research demand. Suppliers typically offer this compound with various purity grades, from technical grade for material science applications to pharmaceutical grade for drug development purposes. Proper storage conditions (typically cool, dry environments protected from light) ensure long-term stability of this valuable chemical intermediate.

Regulatory considerations for CAS 1093211-85-8 vary by region and application. While not classified as hazardous under standard regulations, researchers should consult current chemical safety guidelines when handling this compound. Standard laboratory precautions including proper ventilation and personal protective equipment are recommended when working with this or any chemical substance.

Future research directions for 1-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperazine include exploration of its potential in targeted drug delivery systems and bioconjugation chemistry. The compound's modular structure lends itself well to these cutting-edge applications, particularly in the development of theranostic agents that combine therapeutic and diagnostic capabilities. As synthetic methodologies continue to advance, we can expect to see novel derivatives of this scaffold with enhanced biological activities and material properties.

The scientific literature contains numerous references to CAS 1093211-85-8 and related structures, reflecting the compound's importance in contemporary research. Recent publications have highlighted its use in medicinal chemistry programs targeting various neurological disorders, as well as its application in catalysis and materials engineering. These studies collectively demonstrate the versatility and potential of this fascinating chemical entity.

For researchers seeking to work with 1-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperazine, it's essential to source high-quality material from reputable suppliers. Key specifications to evaluate include chemical purity, isomeric composition, and residual solvent content. Many suppliers now provide comprehensive analytical data packages to support research and development efforts involving this compound.

In conclusion, CAS 1093211-85-8 represents an important addition to the toolkit of synthetic and medicinal chemists. Its unique combination of fluorinated aromatic and piperazine moieties offers numerous opportunities for innovation in drug discovery and materials science. As research into this compound and its derivatives continues to expand, we anticipate significant advancements stemming from applications of this versatile chemical scaffold.

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