• 1. Rhodium-catalyzed addition of sulfonyl hydrazides to allenes: regioselective synthesis of branched allylic sulfones
  Vahid Khakyzadeh,Yu-Hsuan Wang,Bernhard Breit Chem. Commun. 2017 53 4966
• 2. Tracer diffusion in proton-exchanged congruent LiNbO3 crystals as a function of hydrogen content
  Lars D?rrer,René Heller,Harald Schmidt Phys. Chem. Chem. Phys. 2022 24 16139
• 3. C–H deuteration of organic compounds and potential drug candidates
  Gaurav Prakash,Nilanjan Paul,Gwyndaf A. Oliver,Daniel B. Werz,Debabrata Maiti Chem. Soc. Rev. 2022 51 3123
• 4. Silver trifluoroacetate as a bifunctional reagent for palladium-catalyzed oxidative carbonylative [4 + 1] annulation of aromatic acids
  Zhuang-Zhuang Li,Wan-Di Li,Juan Fan,Jun-Ting Li,Zhong-Wen Liu,Xian-Ying Shi Org. Chem. Front. 2023 10 2243
• 5. Silver trifluoroacetate as a bifunctional reagent for palladium-catalyzed oxidative carbonylative [4 + 1] annulation of aromatic acids
  Zhuang-Zhuang Li,Wan-Di Li,Juan Fan,Jun-Ting Li,Zhong-Wen Liu,Xian-Ying Shi Org. Chem. Front. 2023 10 2243

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acids

Benzoic Acid-d5: Applications and Significance in Modern Chemical Research

Benzoic Acid-d5, with the chemical formula C?H?D?O?, is a deuterated derivative of benzoic acid (CAS No. 1079-02-3). This compound has gained significant attention in the field of chemical biology and pharmaceutical research due to its unique properties and applications. The introduction of deuterium atoms into the benzoic acid molecule enhances its stability and isotopic purity, making it an invaluable tool for various scientific studies.

The CAS No. 1079-02-3 of benzoic acid-d5 is a critical identifier that distinguishes it from its non-deuterated counterpart. This numerical code ensures precise identification and tracking of the compound in laboratory settings, facilitating accurate experimental outcomes. The benzoic acid-d5 derivative is particularly useful in nuclear magnetic resonance (NMR) spectroscopy, where the deuterated atoms provide a clear distinction between the target compound and other substances present in a mixture.

In recent years, the use of isotopically labeled compounds like benzoic acid-d5 has expanded significantly in pharmaceutical research. These compounds are employed to study metabolic pathways, drug interactions, and the mechanisms of enzymatic reactions. The deuterium-labeled version of benzoic acid allows researchers to monitor the degradation and absorption of drugs more effectively, providing insights that are not possible with non-deuterated analogs.

One of the most compelling applications of benzoic acid-d5 is in the field of mass spectrometry (MS). The additional mass from deuterium atoms improves the resolution and sensitivity of MS analyses, enabling researchers to detect trace amounts of compounds with high accuracy. This capability is particularly crucial in clinical diagnostics, where early detection of biomarkers can significantly impact patient outcomes.

The pharmaceutical industry has also leveraged benzoic acid-d5 in the development of new drugs. By incorporating deuterium atoms into drug molecules, researchers can enhance their pharmacokinetic properties. For instance, deuterated drugs often exhibit longer half-lives and reduced metabolic clearance, leading to more efficient therapeutic effects. This approach has been successfully applied in the development of antiviral and antibacterial agents, where sustained drug activity is essential for treatment efficacy.

Another area where benzoic acid-d5 has made a notable impact is in environmental chemistry. The compound serves as a reference standard for analyzing environmental pollutants, such as benzoic acid derivatives found in water sources. Its isotopic purity ensures that measurements are accurate and reliable, aiding in the assessment of environmental contamination levels.

The synthesis of benzoic acid-d5 involves advanced chemical techniques that require precise control over reaction conditions. Researchers often employ catalytic hydrogenation or isotopic exchange methods to introduce deuterium atoms into the benzene ring or carboxyl group. These synthetic processes highlight the compound's complexity and the expertise required to produce high-quality benzoic acid-d5 for research applications.

In conclusion, benzoic acid-d5 (CAS No. 1079-02-3) is a versatile and highly valuable compound in modern chemical research. Its applications span across pharmaceuticals, environmental science, and analytical chemistry, underscoring its importance in advancing scientific knowledge and innovation. As research methodologies continue to evolve, the demand for isotopically labeled compounds like benzoic acid-d5 is expected to grow, further solidifying its role as a cornerstone in scientific exploration.

• 1335014-65-7(3,5-DIMETHYLBENZOIC-D9 ACID)
• 23074-26-2(Methoxy, (4-methylphenyl)oxo-)
• 74920-45-9(benzoic acid-ring-ul-14c)
• 103362-90-9(1,4-Benzenedimethanol, monobenzoate)
• 68309-47-7(Linseed oil, polymer with isophthalic acid and trimethylolethane)
• 1219798-76-1(p-Toluic Acid-d7)
• 8013-63-6(Caswell No. 081)
• 17217-84-4(Benzoic Acid-18O2)
• 1219798-71-6(P-TOLUIC-2,3,5,6-D4 ACID)
• 181522-18-9(1,3-Benzenedicarboxylic acid, 5-(hydroxymethyl)-)