• 1. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 2. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 3. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 4. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 5. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739

Introduction to 2,6-diethoxybenzaldehyde (CAS No. 107694-28-0)

2,6-diethoxybenzaldehyde, identified by the Chemical Abstracts Service Number (CAS No.) 107694-28-0, is a significant organic compound that has garnered considerable attention in the field of pharmaceutical chemistry and synthetic organic chemistry. This aromatic aldehyde features a benzene ring substituted with two ethoxy groups at the 2- and 6-positions, coupled with a formyl group at the 1-position. Its unique structural attributes make it a versatile intermediate in the synthesis of various pharmacologically active molecules, including potential candidates for medicinal applications.

The compound’s chemical formula is C₁₀H₁₂O₂, reflecting its composition of ten carbon atoms, twelve hydrogen atoms, and two oxygen atoms. As an aldehyde derivative, 2,6-diethoxybenzaldehyde exhibits characteristic reactivity patterns typical of aromatic aldehydes, including electrophilic aromatic substitution and condensation reactions. These properties have positioned it as a valuable building block in organic synthesis, particularly in the construction of more complex molecular architectures.

In recent years, there has been growing interest in exploring the pharmacological potential of 2,6-diethoxybenzaldehyde and its derivatives. The presence of ethoxy groups at the 2- and 6-positions introduces steric and electronic effects that can modulate the compound’s biological activity. Preliminary studies have suggested that derivatives of this scaffold may exhibit properties relevant to neurological and anti-inflammatory applications. For instance, modifications to the benzene ring or the aldehyde functionality could lead to compounds with enhanced binding affinity to specific biological targets.

The synthesis of 2,6-diethoxybenzaldehyde typically involves multi-step organic transformations starting from commercially available precursors. One common approach involves the ethylation of a hydroxylated benzaldehyde precursor followed by formylation at the appropriate position. Advances in catalytic methods have enabled more efficient and sustainable routes to this compound, aligning with the broader goals of green chemistry. These innovations not only improve yield but also reduce waste, making the production of 2,6-diethoxybenzaldehyde more environmentally friendly.

From a research perspective, 2,6-diethoxybenzaldehyde serves as a key intermediate in the development of novel therapeutic agents. Its structural motif is reminiscent of several known bioactive compounds, suggesting that it could be a precursor to drugs targeting various diseases. For example, analogs with similar substitution patterns have shown promise in preclinical studies for their ability to interact with enzymes or receptors involved in metabolic disorders. The aldehyde group provides a reactive site for further functionalization, allowing chemists to tailor the molecule’s properties for specific applications.

The compound’s stability under various conditions makes it suitable for both laboratory-scale investigations and potential industrial applications. Storage conditions typically involve keeping it in an inert atmosphere at controlled temperatures to prevent degradation. Solubility studies have indicated that 2,6-diethoxybenzaldehyde is moderately soluble in organic solvents such as ethanol and dichloromethane but poorly soluble in water, which influences its handling and formulation in pharmaceutical formulations.

In conclusion,2,6-diethoxybenzaldehyde (CAS No. 107694-28-0) is a structurally interesting and synthetically useful compound with significant implications in medicinal chemistry. Its role as an intermediate in drug discovery underscores its importance in modern chemical research. As methodologies for organic synthesis continue to evolve,2,6-diethoxybenzaldehyde will likely remain a relevant and valuable component in the quest for new therapeutic solutions.

• 708-76-9(4,6-Dimethoxysalicylaldehyde)
• 22042-72-4(2-(2-Hydroxyethoxy)benzaldehyde)
• 3392-97-0(2,6-Dimethoxybenzaldehyde)
• 58026-14-5(4-Benzyloxy-2-methoxybenzaldehyde)
• 613-69-4(2-Ethoxybenzaldehyde)
• 830-79-5(2,4,6-Trimethoxybenzaldehyde)
• 18278-34-7(4-Hydroxy-2-methoxybenzaldehyde)
• 700-44-7(2-Hydroxy-6-methoxybenzaldehyde)
• 613-45-6(2,4-Dimethoxybenzaldehyde)
• 19523-57-0(2-ethoxynaphthalene-1-carbaldehyde)