Cas no 1076198-18-9 (ortho Gliclazide)
Ortho Gliclazide is a sulfonylurea derivative used primarily in the management of type 2 diabetes mellitus. It functions by stimulating insulin secretion from pancreatic beta cells, thereby improving glycemic control. Key advantages include its selective action on ATP-sensitive potassium channels, which enhances glucose-dependent insulin release and minimizes hypoglycemic risk. Ortho Gliclazide also exhibits antioxidant properties, potentially reducing oxidative stress associated with diabetes. Its modified-release formulation ensures prolonged pharmacokinetic stability, allowing for once-daily dosing and improved patient compliance. The compound demonstrates high bioavailability and low protein binding, contributing to consistent therapeutic effects. It is particularly suitable for patients requiring precise glycemic regulation with a reduced incidence of adverse effects.
ortho Gliclazide structure
Product Name:ortho Gliclazide
CAS No:1076198-18-9
MF:C15H21N3O3S
MW:323.41054224968
CID:1060002
PubChem ID:46780435
Update Time:2025-05-28
ortho Gliclazide Chemical and Physical Properties
Names and Identifiers
-
- ortho Gliclazide
- 1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(2-methylphenyl)sulfonylurea
- Gliclazide impurity F
- 1-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-[(2-methylphenyl)sulphonyl]urea
- N-[[(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-2-methylbenzenesulfonamide
- STL450903
- 1076198-18-9
- ortho-Gliclazide
- N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-2-methylbenzenesulfonamide
- ortho Gliclazide (Gliclazide Impurity)
- N-((Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)carbamoyl)-2-methylbenzenesulfonamide
- N-[[(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-2-methyl benzenesulfonamide
- DTXSID50675626
- 1-(2-methylbenzenesulfonyl)-3-{octahydrocyclopenta[c]pyrrol-2-yl}urea
- N-[(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)carbamoyl]-2-methylbenzene-1-sulfonamide
- 1-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-[(2-methylphenyl)sulphonyl]urea; Gliclazide Imp. F (EP); Gliclazide Impurity F
- N-[[(HEXAHYDROCYCLOPENTA [C]PYRROL-2(1H)-YL)AMINO]CARBONYL]-2-METHYL BENZENESULFONAMIDE
-
- Inchi： 1S/C15H21N3O3S/c1-11-5-2-3-8-14(11)22(20,21)17-15(19)16-18-9-12-6-4-7-13(12)10-18/h2-3,5,8,12-13H,4,6-7,9-10H2,1H3,(H2,16,17,19)
- InChI Key： XLSAYFQNZDWDHT-UHFFFAOYSA-N
- SMILES： S(C1C=CC=CC=1C)(NC(NN1CC2CCCC2C1)=O)(=O)=O
Computed Properties
- Exact Mass: 323.13000
- Monoisotopic Mass: 323.13
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 22
- Rotatable Bond Count: 3
- Complexity: 505
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 2
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 86.9A^2
- XLogP3: 3
Experimental Properties
- Density: 1.35±0.1 g/cm3 (20 oC 760 Torr),
- Melting Point: 160 - 164°C
- Solubility: Very slightly soluble (0.12 g/l) (25 o C),
- PSA: 90.38000
- LogP: 3.24380
ortho Gliclazide Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：-20?°C Freezer
ortho Gliclazide Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | G409880-100mg |
ortho Gliclazide |
1076198-18-9 | 100mg |
$ 221.00 | 2023-09-07 | ||
| TRC | G409880-1g |
ortho Gliclazide |
1076198-18-9 | 1g |
$ 1669.00 | 2023-09-07 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | G0326012 |
ortho Gliclazide |
1076198-18-9 | European Pharmacopoeia (EP) Reference Standard | ￥2654.27 | 2022-02-23 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | BP366 |
Gliclazide impurity F |
1076198-18-9 | British Pharmacopoeia (BP) Reference Standard | ￥2261.2 | 2022-02-22 | ||
| Chemenu | CM197333-1g |
N-((hexahydrocyclopenta[c]pyrrol-2(1H)-yl)carbamoyl)-2-methylbenzenesulfonamide |
1076198-18-9 | 95% | 1g |
$899 | 2023-03-07 | |
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | -30mg |
Gliclazide impurity F |
1076198-18-9 | 30mg |
￥1897.11 | 2023-09-09 | ||
| TRC | G409880-1000mg |
ortho Gliclazide |
1076198-18-9 | 1g |
$1669.00 | 2023-05-18 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | BP366 |
1076198-18-9 | 30MG |
￥2339.9 | 2023-01-06 | |||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | G0326012 |
1076198-18-9 | ￥1556.7 | 2023-01-14 | ||||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | BP366-30mg |
Gliclazide impurity F |
1076198-18-9 | 30mg |
￥1958.23 | 2025-01-16 |
ortho Gliclazide Related Literature
-
Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
-
Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
-
Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
-
Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
-
Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
1076198-18-9 (ortho Gliclazide) Related Products
- 38173-52-3(Carboxy Gliclazide)
- 1188264-75-6([2H7]-Gliclazide)
- 1443-94-3(Benzenesulfonamide,4-methyl-N-[(1-piperidinylamino)carbonyl]-)
- 1443-97-6(Benzenesulfonamide,N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-)
- 21187-99-5(Benzenesulfonamide,4-chloro-N-[[(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-)
- 21187-98-4(Gliclazide)
- 1156-19-0(Tolazamide)
- 1185039-30-8(Gliclazide-d4)
- 3074-35-9(1H-Indene-5-sulfonamide,N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-2,3-dihydro-)
- 87368-00-1(Hydroxy Gliclazide)
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