• 1. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 2. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 3. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 4. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 5. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

Introduction to 3-Chloro-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS No. 1073353-71-5)

3-Chloro-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS No. 1073353-71-5) is a versatile compound that has gained significant attention in the fields of organic synthesis and medicinal chemistry. This compound is a pyridine derivative functionalized with a chloro and fluoro substituent on the aromatic ring and a boronic acid pinacol ester group. The unique combination of these functional groups makes it an attractive building block for the synthesis of complex molecules with potential applications in pharmaceuticals and materials science.

The boronic acid pinacol ester group in 3-Chloro-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is particularly noteworthy due to its reactivity in Suzuki-Miyaura coupling reactions. These reactions are widely used in the synthesis of biologically active compounds and pharmaceutical intermediates. The presence of the boronic acid pinacol ester allows for efficient and selective coupling with various aryl and vinyl halides, making it a valuable reagent in the development of new drugs.

The chloro and fluoro substituents on the pyridine ring contribute to the compound's electronic properties and reactivity. Chlorine and fluorine are known for their strong electron-withdrawing effects, which can influence the reactivity of adjacent functional groups. This property is particularly useful in fine-tuning the reactivity and selectivity of intermediates in synthetic pathways. Additionally, the presence of these halogens can enhance the solubility and bioavailability of final products, which is crucial for pharmaceutical applications.

Recent research has highlighted the potential of 3-Chloro-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine in the development of novel therapeutics. For instance, a study published in the Journal of Medicinal Chemistry demonstrated that this compound can be used as a key intermediate in the synthesis of potent inhibitors of protein-protein interactions (PPIs). PPI inhibitors are an emerging class of drugs that target protein interactions involved in various diseases, including cancer and neurodegenerative disorders.

In another study, researchers at a leading pharmaceutical company utilized 3-Chloro-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine to synthesize a series of pyridine-based compounds with antiviral activity. The resulting compounds showed promising efficacy against several viral strains, including influenza and hepatitis C viruses. This research underscores the compound's potential as a platform for developing new antiviral agents.

The versatility of 3-Chloro-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine extends beyond pharmaceutical applications. In materials science, this compound has been explored for its use in the synthesis of functional polymers and organic semiconductors. The unique electronic properties conferred by the chloro and fluoro substituents make it suitable for applications in organic electronics and photovoltaic devices.

In conclusion, 3-Chloro-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS No. 1073353-71-5) is a highly versatile compound with significant potential in both medicinal chemistry and materials science. Its unique combination of functional groups makes it an invaluable building block for the synthesis of complex molecules with diverse applications. Ongoing research continues to uncover new possibilities for this compound, further solidifying its importance in modern chemical research.

• 458532-86-0(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine)
• 458532-90-6(3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine)
• 2711075-63-5(3-chloro-2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-4,6-d2)
• 2241870-40-4(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3,5,6-d3)
• 937595-72-7(5-Chloro-2-fluoropyridine-3-boronic acid pinacol ester)
• 1220219-73-7(3-Chloro-2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine)
• 1257641-28-3(3,5-Dichloro-4-pyridineboronic acid pinacol ester)
• 1204333-58-3(2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine)
• 1310383-58-4(5-Chloro-2-fluoropyridine-4-boronic acid pinacol ester)
• 1146615-89-5(2-Chloro-6-fluoropyridine-4-boronic Acid Pinacol Ester)