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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Fluorobenzenes

2,3-Difluorophenylboronic Acid Pinacol Ester (CAS No. 1073339-17-9): Properties, Applications, and Market Insights

The 2,3-Difluorophenylboronic acid pinacol ester (CAS No. 1073339-17-9) is a highly valuable boronic ester compound widely used in organic synthesis, pharmaceutical research, and material science. This fluorinated phenylboronic ester is known for its stability and reactivity, making it a preferred choice for Suzuki-Miyaura cross-coupling reactions, a key methodology in modern synthetic chemistry.

With the increasing demand for fluorinated organic compounds in drug discovery and agrochemical development, 2,3-difluorophenylboronic acid derivatives have gained significant attention. Researchers are particularly interested in how the pinacol ester group enhances the compound's stability while maintaining its reactivity in various coupling reactions. This makes CAS 1073339-17-9 an essential building block for creating complex molecular structures.

The 2,3-difluoro substitution pattern on the phenyl ring offers unique electronic properties that influence the compound's behavior in chemical reactions. Many scientists are exploring how this difluorophenyl boronate can be used to develop new PET imaging agents and biologically active molecules, especially in the context of neurodegenerative disease research and cancer therapeutics.

From a synthetic chemistry perspective, the pinacol protecting group in 2,3-difluorophenylboronic acid pinacol ester provides several advantages. It protects the boronic acid functionality from unwanted side reactions while allowing for clean deprotection when needed. This characteristic has made CAS 1073339-17-9 particularly valuable in multi-step synthetic routes where selective reactivity is crucial.

Recent trends in green chemistry have highlighted the importance of boronic ester compounds like 2,3-difluorophenylboronic acid pinacol ester in developing more sustainable synthetic methodologies. Their ability to participate in metal-catalyzed cross-coupling reactions under mild conditions aligns well with the pharmaceutical industry's push toward environmentally friendly processes.

The stability of 2,3-difluorophenylboronic acid pinacol ester makes it particularly suitable for storage and transportation compared to its boronic acid counterpart. This practical advantage, combined with its synthetic versatility, explains why many chemical suppliers now offer difluorophenyl boronic esters as standard catalog items for research laboratories.

In material science applications, researchers are investigating how fluorinated phenylboronic esters can be incorporated into advanced polymers and electronic materials. The unique electronic properties imparted by the 2,3-difluoro substitution may lead to materials with improved performance in organic electronics and sensor technologies.

Quality control of 2,3-difluorophenylboronic acid pinacol ester typically involves rigorous analytical techniques including NMR spectroscopy, HPLC analysis, and mass spectrometry. These methods ensure the compound meets the high purity standards required for pharmaceutical applications and sensitive synthetic transformations.

The global market for boronic acid derivatives continues to expand, with 2,3-difluorophenylboronic acid pinacol ester representing a growing segment. Pharmaceutical companies and contract research organizations are increasingly sourcing this compound for drug discovery programs targeting various therapeutic areas.

When handling 2,3-difluorophenylboronic acid pinacol ester, standard laboratory precautions for organic compounds should be followed. While not classified as hazardous under normal conditions, proper storage in cool, dry environments helps maintain the compound's stability and shelf life.

Future research directions for CAS 1073339-17-9 may explore its potential in catalytic systems and as a precursor for novel fluorinated materials. The continued development of boron-containing compounds in medicinal chemistry suggests that 2,3-difluorophenylboronic acid pinacol ester will remain an important research chemical for years to come.

For synthetic chemists working on complex molecule construction, understanding the reactivity patterns of difluorophenyl boronic esters is essential. The 2,3-difluorophenyl moiety often imparts desirable pharmacokinetic properties to drug candidates, making this compound particularly valuable in medicinal chemistry applications.

As the demand for fluorinated building blocks grows, suppliers of 2,3-difluorophenylboronic acid pinacol ester are expanding their production capabilities. This ensures researchers have reliable access to high-quality material for their synthetic needs across various chemical disciplines.

• 863868-37-5(2,6-Difluorophenylboronic acid, pinacol ester)
• 408492-24-0(2,2',2''-(2,4,6-Trifluorobenzene-1,3,5-triyl)tris(4,4,5,5-tetramethyl-1,3,2-dioxaborolane))
• 876062-39-4(2-(2-Fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
• 936618-92-7(3-Fluorophenylboronic acid pinacol ester)
• 303006-90-8(2-[2,5-difluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
• 819057-45-9(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline)
• 1073339-12-4(5-Bromo-2,3-difluorophenylboronic Acid Pinacol Ester)
• 288101-48-4(2,4-Difluorophenylboronic acid, pinacol ester)
• 827614-70-0(4,4,5,5-Tetramethyl-2-(3,4,5-trifluorophenyl)-1,3,2-dioxaborolane)
• 325142-81-2(4,4,5,5-Tetramethyl-2-(perfluorophenyl)-1,3,2-dioxaborolane)