Production Method 1

1193-55-1

1070-62-8

818-38-2

Reaction Conditions

1.1 Reagents: Potassium peroxymonosulfate Solvents: Ethanol ;  18 h, rt

Reference

Direct oxidative cleavage of α- and β-dicarbonyls and α-hydroxy ketones to diesters with KHSO5

Yan, Jun; et al, Journal of Organic Chemistry, 2004, 69(26), 9299-9302

Ethyl hydrogen glutarate Raw materials

• 2-Methylcyclohexane-1,3-dione

Ethyl hydrogen glutarate Preparation Products

• Ethyl hydrogen glutarate (1070-62-8)
• Diethyl glutarate (818-38-2)

• 1. Investigation on the structural features of Zhundong subbituminous coal through ruthenium ion-catalyzed oxidation
  Jing-Hui Lv,Xian-Yong Wei,Ying-Hua Wang,Tie-Min Wang,Jing Liu,Dong-Dong Zhang,Zhi-Min Zong RSC Adv. 2016 6 11952

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acid esters
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Recent Advances in the Study of Ethyl Hydrogen Glutarate (CAS 1070-62-8): A Comprehensive Research Brief

Ethyl hydrogen glutarate (EHG), with the CAS number 1070-62-8, is a chemical compound of significant interest in the field of chemical biology and pharmaceutical research. This ester derivative of glutaric acid has garnered attention due to its potential applications in drug synthesis, biodegradable polymers, and as an intermediate in organic synthesis. Recent studies have explored its physicochemical properties, biological activities, and industrial applications, making it a versatile candidate for further research and development.

One of the key areas of focus in recent research has been the role of EHG in drug delivery systems. A 2023 study published in the Journal of Controlled Release demonstrated that EHG-based polymers exhibit excellent biocompatibility and controlled release properties, making them suitable for encapsulating hydrophobic drugs. The study highlighted that EHG's unique ester linkage allows for tunable degradation rates, which can be tailored to specific therapeutic needs. This finding opens new avenues for designing targeted drug delivery systems with improved efficacy and reduced side effects.

In addition to its pharmaceutical applications, EHG has been investigated for its potential in green chemistry. A recent paper in Green Chemistry (2024) reported the use of EHG as a bio-based solvent for organic reactions. The study emphasized EHG's low toxicity and high biodegradability, positioning it as a sustainable alternative to traditional organic solvents. Researchers also noted that EHG's ability to dissolve a wide range of organic compounds makes it particularly valuable for environmentally friendly synthesis processes.

Another groundbreaking study, published in Biomacromolecules in early 2024, explored the use of EHG in the development of biodegradable plastics. The research team successfully synthesized a series of polyesters using EHG as a monomer, which exhibited remarkable mechanical strength and biodegradability under environmental conditions. These findings suggest that EHG-derived polymers could play a pivotal role in addressing the global plastic waste crisis, offering a viable alternative to petroleum-based plastics.

From a biological perspective, EHG has shown promise in antimicrobial applications. A 2023 study in the European Journal of Medicinal Chemistry investigated the antimicrobial activity of EHG derivatives against multidrug-resistant bacterial strains. The results indicated that certain EHG analogs exhibited potent antibacterial effects, particularly against Gram-positive bacteria. This research underscores the potential of EHG as a scaffold for developing novel antimicrobial agents in an era of increasing antibiotic resistance.

Despite these advancements, challenges remain in the large-scale production and purification of EHG. Recent technical reports have highlighted the need for more efficient synthetic routes and purification methods to make EHG commercially viable for various applications. Ongoing research is focusing on enzymatic synthesis and continuous flow chemistry as potential solutions to these challenges.

In conclusion, Ethyl hydrogen glutarate (CAS 1070-62-8) continues to emerge as a multifunctional compound with diverse applications in pharmaceuticals, green chemistry, and materials science. The recent studies discussed in this brief demonstrate its versatility and potential for addressing critical challenges in these fields. Future research directions may include further optimization of EHG-based drug delivery systems, exploration of its therapeutic potential beyond antimicrobial applications, and scaling up production methods for industrial use.

• 42232-59-7(Octadecanoic acid, heneicosyl ester)
• 2380-17-8
• 64885-13-8(1,18,35,52-TETRAOXACYCLOOCTAHEXACONTANE-2,19,36,53-TETRONE)
• 101083-38-9
• 42231-45-8(Octanoic acid, eicosyl ester)
• 42231-47-0(Octanoic acid, docosyl ester)
• 42231-43-6(Octanoic acid, heptadecyl ester)
• 64885-11-6(1,18,35-TRIOXACYCLOHENPENTACONTANE-2,19,36-TRIONE)
• 64885-15-0(1,10,19-TRIOXACYCLOHEPTACOSANE-2,11,20-TRIONE)
• 42231-42-5(Octanoic acid, pentadecyl ester)