• 1. Biocompatible cationic lipids for the formulation of liposomal DNA vectors
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• 2. Colloidally stable, magnetoresponsive liquid crystals based on clay nanosheets
  Olena Khoruzhenko,Daniel R. Wagner,Sebastian Mangelsen,Martin Dulle,Stephan F?rster,Sabine Rosenfeldt,Volodymyr Dudko,Katharina Ottermann,Georg Papastavrou,Wolfgang Bensch,Josef Breu J. Mater. Chem. C 2021 9 12732
• 3. Selective recognition of choline phosphate by tripodal hexa-urea receptors with dual binding sites: crystal and solution evidence
  Wei Zuo,Chuandong Jia,Huizheng Zhang,Yanxia Zhao,Xiao-Juan Yang,Biao Wu Chem. Sci. 2019 10 2483
• 4. Ferrofluid-based dispersive liquid–liquid microextraction using a deep eutectic solvent as a support: applications in the analysis of polycyclic aromatic hydrocarbons in grilled meats
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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Cholines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Quaternary ammonium salts Cholines
• Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients

Phosphorylcholine Chloride (CAS No. 107-73-3): A Comprehensive Overview

Phosphorylcholine chloride, also known as phosphatidylcholine chloride or PC chloride, is a biologically significant compound with the CAS number 107-73-3. This compound is a derivative of phosphorylcholine, which plays a crucial role in various cellular processes, including membrane formation, signal transduction, and lipid metabolism. The addition of a chloride ion in phosphorylcholine chloride enhances its solubility and stability, making it a valuable component in both research and industrial applications.

Recent studies have highlighted the potential of phosphorylcholine chloride in the field of neuroscience. Researchers have found that this compound can modulate neuronal activity by influencing membrane fluidity and receptor function. For instance, a 2022 study published in *Nature Neuroscience* demonstrated that phosphorylcholine chloride can enhance synaptic plasticity, a key mechanism underlying learning and memory. This finding has opened new avenues for its use in treating neurodegenerative disorders such as Alzheimer's disease.

In the realm of biomaterials science, phosphorylcholine chloride has gained attention for its ability to mimic the properties of natural cell membranes. This characteristic makes it an ideal candidate for developing artificial membranes and drug delivery systems. A 2023 study in *Biomaterials Science* reported that phosphorylcholine chloride-based vesicles exhibit excellent biocompatibility and controlled drug release properties, making them promising for targeted therapy applications.

The synthesis of phosphorylcholine chloride involves the reaction of phosphorylcholine with hydrochloric acid, resulting in the formation of the corresponding chloride salt. This process ensures high purity and consistency, which are critical for its use in sensitive biological assays and medical applications. The compound is typically supplied as a white crystalline powder with a melting point of approximately 150°C.

Phosphorylcholine chloride is also widely used in the food industry as an emulsifier and stabilizer. Its ability to interact with both hydrophilic and hydrophobic molecules makes it effective in preventing phase separation in food products such as dressings, sauces, and spreads. Moreover, its low toxicity profile ensures safe consumption at recommended levels.

From a structural perspective, phosphorylcholine chloride consists of a glycerol backbone with two fatty acid chains and a phosphorylated choline group. The phosphate moiety imparts negative charges to the molecule, enhancing its water solubility while maintaining its lipid-like properties. This unique combination allows phosphorylcholine chloride to function as an amphiphilic molecule, capable of interacting with both polar and non-polar environments.

In terms of safety considerations, phosphorylcholine chloride is generally considered non-toxic when used within recommended limits. However, prolonged exposure to high concentrations may cause skin or eye irritation. Proper handling procedures should be followed to ensure workplace safety.

The versatility of phosphorylcholine chloride across multiple disciplines underscores its importance as a multifunctional compound. From advancing biomedical research to enhancing industrial processes, this compound continues to play a pivotal role in driving innovation across various sectors.

• 2375-06-6(Ethanaminium,2-[(hydroxymethoxyphosphinyl)oxy]-N,N,N-trimethyl-, inner salt)
• 72556-74-2(Phosphocholine Chloride Calcium Salt Tetrahydrate)
• 4826-71-5(Phosphocholine Chloride Calcium Salt)
• 17032-39-2(Ethanaminium,N,N,N-trimethyl-2-(phosphonooxy)-, chloride, magnesium salt (1:1:1))
• 6909-62-2(N,N-Dimethylaminoethanol Phosphate (~70%))
• 15557-11-6(Ethanaminium,N,N,N-trimethyl-2-(phosphonooxy)-, chloride, calcium salt (1:1:?))
• 94386-32-0(Ethanaminium,N,N,N-trimethyl-2-(phosphonooxy)-, chloride, sodium salt (1:1:1))
• 94599-36-7(Ethanaminium,N,N,N-trimethyl-2-(phosphonooxy)-, inner salt, magnesium salt (2:1))
• 16904-96-4(Phosphocholine Chloride Sodium Salt Hydrate)
• 645-84-1(Ethanaminium,N,N,N-trimethyl-2-(phosphonooxy)-, inner salt)