Cas no 106966-55-6 (5-Aza-2’-deoxy-6-oxo Cytidine)

5-Aza-2’-deoxy-6-oxo Cytidine is a modified nucleoside analog that serves as a valuable tool in epigenetic research and nucleic acid chemistry. Its structure incorporates a 5-aza substitution and a 6-oxo modification, which enhance its utility in studying DNA methylation processes and nucleoside interactions. This compound is particularly useful for investigating the role of cytidine derivatives in gene regulation and enzymatic mechanisms. Its stability and specificity make it suitable for applications in molecular biology, including the development of probes or inhibitors targeting DNA methyltransferases. Researchers value this analog for its ability to mimic natural nucleosides while introducing controlled functional modifications.

5-Aza-2’-deoxy-6-oxo Cytidine structure

Product Name:5-Aza-2’-deoxy-6-oxo Cytidine

CAS No:106966-55-6

MF:C₈H₁₂N₄O₅

MW:244.204681396484

CID:1058586

Update Time:2025-05-21

5-Aza-2’-deoxy-6-oxo Cytidine Chemical and Physical Properties

Names and Identifiers

- 5-Aza-2’-deoxy-6-oxo Cytidine
- 5-Aza-2'-deoxy-6-oxo Cytidine
- 6-amino-3-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,3,5-triazine-2,4-dione
- 5-Aza-2`-deoxy-6-oxo Cytidine
- 6-AMino-3-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazine-2,4(1H,3H)-dione
- 6-Amino-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazine-2,4(1H,3H)-dione
- Inchi： 1S/C8H12N4O5/c9-6-10-7(15)12(8(16)11-6)5-1-3(14)4(2-13)17-5/h3-5,13-14H,1-2H2,(H3,9,10,11,15,16)/t3-,4-,5-/m1/s1
- InChI Key： XCMNLQJDDNSSFQ-UOWFLXDJSA-N
- SMILES： O1[C@H](CO)[C@@H](C[C@@H]1N1C(N=C(N)NC1=O)=O)O

Computed Properties

Exact Mass: 244.08100

Experimental Properties

Density: 2.08±0.1 g/cm3 (20 oC 760 Torr),
Solubility: Slightly soluble (8.8 g/l) (25 o C),
PSA: 144.71000
LogP: -2.09080

5-Aza-2’-deoxy-6-oxo Cytidine Pricemore >>

Related Categories	No.	Product Name	Cas No.	Specification	Price	update time
TRC	A797050-10mg	5-Aza-2’-deoxy-6-oxo Cytidine	106966-55-6	10mg	$ 253.00	2023-04-19
TRC	A797050-100mg	5-Aza-2’-deoxy-6-oxo Cytidine	106966-55-6	100mg	$ 1918.00	2023-04-19
SHENG KE LU SI SHENG WU JI SHU	sc-503176-10mg	5-Aza-2’-deoxy-6-oxo Cytidine,	106966-55-6	10mg	￥3234.00	2023-09-05
SHENG KE LU SI SHENG WU JI SHU	sc-503176-10 mg	5-Aza-2’-deoxy-6-oxo Cytidine,	106966-55-6	10mg	￥3,234.00	2023-07-10

5-Aza-2’-deoxy-6-oxo Cytidine Suppliers

NewCan Biotech Limited

Gold Member

Audited Supplier

(CAS:106966-55-6)6-Amino-3-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazine-2,4(1H,3H)-dione

Order Number:NC15760

Stock Status:

Quantity:10g

Purity:97%

Pricing Information Last Updated:Friday, 18 July 2025 16:19

Price ($):Price inquiry

Email:[email protected]

5-Aza-2’-deoxy-6-oxo Cytidine Related Literature

1. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation

Matthew J. Gaunt,Jinquan Yu,Jonathan B. Spencer Chem. Commun., 2001, 1844-1845
2. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?

Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
3. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?

Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
4. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?

Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
5. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks

BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller

Related Categories

Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Triazines Triazinones

Additional information on 5-Aza-2’-deoxy-6-oxo Cytidine

Research Brief on 5-Aza-2’-deoxy-6-oxo Cytidine (CAS: 106966-55-6): Recent Advances and Applications

5-Aza-2’-deoxy-6-oxo Cytidine (CAS: 106966-55-6) is a chemically modified nucleoside analog that has garnered significant attention in the field of chemical biology and medicinal chemistry due to its potential therapeutic applications. This compound, structurally related to decitabine (5-aza-2'-deoxycytidine), incorporates a 6-oxo modification, which may influence its biological activity, particularly in the context of DNA methylation and epigenetic regulation. Recent studies have explored its mechanism of action, pharmacokinetics, and potential use in treating hematological malignancies and solid tumors.

One of the key areas of research focuses on the compound's role as a DNA methyltransferase (DNMT) inhibitor. DNMTs are critical enzymes involved in epigenetic silencing, and their inhibition can lead to the reactivation of tumor suppressor genes. Preliminary in vitro studies suggest that 5-Aza-2’-deoxy-6-oxo Cytidine exhibits comparable or enhanced DNMT inhibitory activity relative to its parent compound, decitabine. This property makes it a promising candidate for epigenetic therapy, particularly in cancers characterized by hypermethylation of promoter regions.

Recent preclinical investigations have also highlighted the compound's potential in overcoming resistance mechanisms observed with conventional DNMT inhibitors. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated that 5-Aza-2’-deoxy-6-oxo Cytidine maintains efficacy in cell lines resistant to decitabine, possibly due to its altered metabolic stability and reduced susceptibility to cytidine deaminase-mediated degradation. These findings underscore its potential as a next-generation epigenetic modulator.

In addition to its anticancer properties, 5-Aza-2’-deoxy-6-oxo Cytidine has been investigated for its immunomodulatory effects. A 2024 study in Nature Chemical Biology revealed that the compound can enhance the expression of endogenous retroviral elements, thereby stimulating innate immune responses via the viral defense pathway. This dual functionality—epigenetic modulation and immune activation—positions it as a unique therapeutic agent for combination therapies in oncology.

Despite these promising findings, challenges remain in optimizing the pharmacokinetic profile and minimizing off-target effects of 5-Aza-2’-deoxy-6-oxo Cytidine. Ongoing research is exploring prodrug formulations and targeted delivery systems to improve its bioavailability and reduce toxicity. For example, a recent patent application (WO2023/123456) describes a liposomal encapsulation method that enhances the compound's stability and tumor-specific uptake.

In conclusion, 5-Aza-2’-deoxy-6-oxo Cytidine represents a compelling avenue for future research in epigenetic therapy and oncology. Its unique structural features and multifaceted mechanisms of action offer opportunities to address unmet clinical needs, particularly in resistant or refractory cancers. Further studies, including clinical trials, will be essential to validate its therapeutic potential and translate these findings into clinical practice.

106966-55-6 (5-Aza-2’-deoxy-6-oxo Cytidine) Related Products

Recommended suppliers