• 1. Fe3O4 nanosphere@microporous organic networks: enhanced anode performances in lithium ion batteries through carbonization?
  Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
• 2. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 3. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 4. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 5. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbohydrates and carbohydrate conjugates Glycosyl compounds

Comprehensive Overview of 5-Azauridine (CAS No. 1476-82-0): Mechanism, Applications, and Research Insights

5-Azauridine (CAS No. 1476-82-0), a pyrimidine nucleoside analog, has garnered significant attention in biochemical and pharmaceutical research due to its unique properties. This compound, also known as 5-AZUR or Azauracil riboside, is structurally similar to uridine but features a nitrogen substitution at the 5-position of the pyrimidine ring. This modification confers distinct biological activities, making it a valuable tool in studying RNA metabolism and epigenetic regulation. Researchers frequently search for terms like "5-Azauridine mechanism of action" or "5-Azauridine vs. 5-Azacytidine", highlighting its relevance in comparative studies with other nucleoside analogs.

The primary mechanism of 5-Azauridine involves its incorporation into RNA, where it disrupts normal nucleic acid synthesis. Unlike 5-Azacytidine, which primarily targets DNA methylation, 5-Azauridine exerts its effects through RNA interference, making it a subject of interest in antiviral research and cancer therapy. Recent studies explore its potential in modulating gene expression and immune response, aligning with trending topics like "RNA-targeted therapeutics" and "epigenetic drugs". Its ability to inhibit orotidine-5'-monophosphate decarboxylase (OMP decarboxylase) further links it to metabolic disorders, a hot topic in precision medicine.

In the context of drug discovery, 5-Azauridine is often compared to newer nucleoside analogs, with searches like "5-Azauridine clinical trials" reflecting user interest in its translational potential. While not yet FDA-approved, preclinical data suggest applications in viral infections (e.g., flaviviruses) and autoimmune diseases. Its low toxicity profile in non-proliferating cells enhances its appeal for chronic conditions, a key focus in long-term therapeutic strategies.

From a technical perspective, 5-Azauridine is soluble in water and dimethyl sulfoxide (DMSO), facilitating in vitro experiments. Researchers frequently inquire about "5-Azauridine solubility" or "stability in cell culture", underscoring practical considerations for experimental design. Its molecular formula (C₈H₁₁N₃O₆) and molar mass (245.19 g/mol) are critical for dosage calculations, particularly in high-throughput screening assays.

Emerging trends also tie 5-Azauridine to RNA epigenetics (e.g., m⁶A modification studies) and senescence research, areas gaining traction in aging biology. Queries like "5-Azauridine and telomerase" indicate interdisciplinary interest. As synthetic biology advances, its role in nucleoside engineering may expand, particularly for modified mRNA therapeutics—a field revolutionized by COVID-19 vaccine development.

In summary, 5-Azauridine (CAS No. 1476-82-0) remains a versatile compound with untapped potential. Its dual role as a research reagent and investigational therapeutic aligns with current demands for multi-target agents and RNA-based interventions. Continued exploration of its structure-activity relationships and synergistic combinations (e.g., with kinase inhibitors) will likely shape future applications in biomedicine.

• 22432-96-8(1,3,5-Triazine-2,4,6(1H,3H,5H)-trione,1-b-D-ribofuranosyl-)
• 18771-50-1(3,4,5,6-Tetrahydrouridine (>80%))
• 114522-22-4(1,3,5-Triazine-2,4(1H,3H)-dione,dihydro-1-b-D-ribofuranosyl-)
• 57350-36-4(1,3,5-Triazine-2,4(1H,3H)-dione,1-(2-deoxy-b-D-erythro-pentofuranosyl)dihydro-5-methyl-)
• 64623-35-4(Urea, N-b-D-arabinofuranosyl-N,N'-dimethyl-)
• 64623-28-5(Urea, N-b-D-arabinofuranosyl-N'-methyl-)
• 30100-83-5(5,6-Dihydro-ara-uridine)
• 22432-97-9(s-Triazine-2,4,6(1H,3H,5H)-trione,1-methyl-3-b-D-ribofuranosyl- (8CI))
• 5627-05-4(5,6-Dihydrouridine)
• 52019-17-7(6-Oxa-2,4-diazabicyclo[3.2.1]octan-3-one,8-hydroxy-7-(hydroxymethyl)-4-methyl-, [1S-(exo,syn)]- (9CI))