• 1. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 2. An integrated system for field analysis of Cd(ii) and Pb(ii) via preconcentration using nano-TiO2/cellulose paper composite and subsequent detection with a portable X-ray fluorescence spectrometer?
  Xiaofeng Lin RSC Adv., 2016,6, 9002-9006
• 3. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535
• 4. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 5. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Oxazoles 2,5-disubstituted oxazoles

Comprehensive Guide to Ethyl 2-bromo-1,3-oxazole-5-carboxylate (CAS No. 1060816-22-9): Properties, Applications, and Market Insights

Ethyl 2-bromo-1,3-oxazole-5-carboxylate (CAS No. 1060816-22-9) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research. This oxazole derivative serves as a versatile building block in organic synthesis, particularly in the development of novel bioactive molecules. With its unique brominated oxazole structure and ester functionality, this compound offers researchers a valuable tool for constructing complex molecular architectures.

The growing demand for ethyl 2-bromo-1,3-oxazole-5-carboxylate reflects its importance in modern drug discovery programs. Recent studies highlight its application in creating potential therapeutic agents targeting various diseases, aligning with current trends in precision medicine and small molecule drug development. The compound's CAS number 1060816-22-9 serves as a unique identifier that helps researchers track its use across different applications and publications.

From a chemical perspective, ethyl 2-bromo-1,3-oxazole-5-carboxylate exhibits several noteworthy characteristics. The bromine substituent at the 2-position of the oxazole ring provides an excellent site for further functionalization through cross-coupling reactions, making it particularly valuable in medicinal chemistry applications. The ester group at the 5-position offers additional versatility, allowing for hydrolysis or transesterification to create various derivatives.

In the context of current research trends, this compound has shown promise in the development of new antimicrobial agents, addressing the global challenge of antibiotic resistance. Scientists are particularly interested in how modifications of the oxazole core structure can lead to compounds with improved biological activity and selectivity. The presence of both bromine and ester functionalities in ethyl 2-bromo-1,3-oxazole-5-carboxylate makes it an ideal starting point for such investigations.

The synthesis and application of CAS 1060816-22-9 have been subjects of numerous recent publications, reflecting its growing importance in chemical research. Many researchers are exploring its use in click chemistry applications and as a precursor for functional materials with potential electronic or optical properties. These applications align well with current interests in green chemistry and sustainable synthesis methods.

Market analysis indicates increasing demand for ethyl 2-bromo-1,3-oxazole-5-carboxylate across pharmaceutical and biotechnology sectors. The compound's unique structural features make it valuable for drug discovery platforms and combinatorial chemistry approaches. Suppliers specializing in heterocyclic building blocks have reported growing interest in this specific oxazole derivative, particularly from research institutions focused on infectious disease therapeutics.

Quality control aspects of ethyl 2-bromo-1,3-oxazole-5-carboxylate production have become increasingly important as its applications expand. Analytical methods such as HPLC and NMR spectroscopy are routinely employed to ensure the purity and consistency of this compound, especially when used in sensitive pharmaceutical applications. The specific CAS number 1060816-22-9 helps maintain traceability throughout the supply chain.

Recent advancements in synthetic methodology have improved access to ethyl 2-bromo-1,3-oxazole-5-carboxylate, making it more available to the research community. These developments support the compound's growing role in high-throughput screening programs and structure-activity relationship studies. The ability to readily modify both the bromine position and ester group allows for efficient exploration of chemical space around this scaffold.

Storage and handling recommendations for CAS 1060816-22-9 follow standard protocols for organic compounds with similar properties. Proper storage conditions help maintain the stability of this oxazole derivative, ensuring consistent performance in research applications. Researchers working with this compound should consult the relevant safety data sheets and implement appropriate laboratory practices.

The future outlook for ethyl 2-bromo-1,3-oxazole-5-carboxylate appears promising, with potential applications extending beyond its current uses. Emerging research areas such as proteolysis targeting chimeras (PROTACs) and covalent inhibitors may benefit from the unique properties of this heterocyclic building block. As synthetic methods continue to evolve, we can anticipate broader adoption of this compound in diverse research programs.

In conclusion, ethyl 2-bromo-1,3-oxazole-5-carboxylate (CAS No. 1060816-22-9) represents a valuable tool for modern chemical research, particularly in pharmaceutical development. Its combination of reactivity and structural versatility makes it an important component in the toolkit of medicinal chemists and materials scientists alike. As research into oxazole-based compounds continues to advance, this specific derivative will likely play an increasingly significant role in scientific discovery and innovation.

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