• 1. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 2. An alternative biorefinery approach to address microalgal seasonality: blending with spent coffee grounds
  Andre Prates Pereira,Tao Dong,Eric P. Knoshaug,Nick Nagle,Ryan Spiller,Bonnie Panczak,Christopher J. Chuck,Philip T. Pienkos Sustainable Energy Fuels, 2020,4, 3400-3408
• 3. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 4. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 5. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471

Chemical Profile of 4-Bromo-2-(4-methylpiperazino)pyridine (CAS No. 1060812-92-1)

4-Bromo-2-(4-methylpiperazino)pyridine, identified by its Chemical Abstracts Service (CAS) number 1060812-92-1, is a significant intermediate in the field of pharmaceutical chemistry. This compound belongs to the class of pyridine derivatives, characterized by its brominated aromatic ring and piperazine moiety. The structural features of this molecule make it a valuable building block for synthesizing more complex pharmacologically active agents.

The bromine substituent at the 4-position of the pyridine ring and the 4-methylpiperazine side chain contribute to the compound's reactivity and versatility in medicinal chemistry. These functional groups are particularly useful in facilitating further chemical transformations, such as nucleophilic aromatic substitution or Suzuki-Miyaura cross-coupling reactions, which are commonly employed in drug development.

In recent years, 4-Bromo-2-(4-methylpiperazino)pyridine has garnered attention in the synthesis of novel therapeutic agents. Its structural motif is reminiscent of several known bioactive compounds, suggesting potential applications in the development of drugs targeting neurological disorders, infectious diseases, and cancer. The piperazine ring, known for its ability to interact with biological targets such as receptors and enzymes, enhances the compound's pharmacological profile.

One of the most compelling aspects of this compound is its role in the synthesis of kinase inhibitors. Kinases are enzymes that play a crucial role in cell signaling pathways, and dysregulation of these pathways is implicated in various diseases, particularly cancer. Researchers have leveraged the reactivity of 4-Bromo-2-(4-methylpiperazino)pyridine to develop inhibitors that target specific kinases by incorporating this scaffold into more elaborate molecular structures.

Recent studies have highlighted the compound's utility in generating small-molecule probes for biochemical assays. These probes are essential tools for understanding the mechanisms of drug action at the molecular level. By using 4-Bromo-2-(4-methylpiperazino)pyridine as a starting material, scientists have been able to develop highly selective inhibitors that modulate kinase activity with high precision.

The methyl group on the piperazine ring is another key feature that influences the compound's behavior. This substituent can affect solubility, metabolic stability, and binding affinity to biological targets. The presence of a methyl group often enhances lipophilicity, which can be advantageous for drug delivery systems that require membrane penetration.

Another area where 4-Bromo-2-(4-methylpiperazino)pyridine has shown promise is in the development of antiviral agents. The bromine atom provides a handle for further functionalization, allowing researchers to attach groups that can interfere with viral replication cycles. For instance, derivatives of this compound have been explored as inhibitors of viral proteases and polymerases.

The synthesis of 4-Bromo-2-(4-methylpiperazino)pyridine itself is an interesting process that highlights modern synthetic methodologies. Traditional approaches often involve multi-step sequences involving halogenation and amination reactions. However, recent advances in catalytic coupling reactions have enabled more efficient synthetic routes, reducing both reaction times and waste generation.

In conclusion, 4-Bromo-2-(4-methylpiperazino)pyridine (CAS No. 1060812-92-1) is a versatile intermediate with broad applications in pharmaceutical research and drug development. Its unique structural features make it an invaluable tool for synthesizing novel bioactive compounds targeting various therapeutic areas. As research continues to uncover new applications for this compound, its importance in medicinal chemistry is likely to grow further.

• 1201643-59-5(1-(4-bromo-2-pyridyl)piperazine)
• 1142194-28-2(4-Bromo-N,N-diethylpyridin-2-amine)
• 73406-97-0(5-Bromo-2-(piperazin-1-yl)pyridine)
• 364794-57-0(5-Bromo-2-(4-ethylpiperidino)pyridine)
• 1289089-99-1(N2-(4-bromo-2-pyridinyl)-N1,N1-dimethyl-1,2-Ethanediamine)
• 863665-35-4(ISOQUINOLINE, 7-BROMO-1-(4-METHYL-1-PIPERAZINYL)-)
• 1246441-88-2(7-Bromo-1-(piperazin-1-yl)isoquinoline hydrochloride)
• 364794-58-1(5-Bromo-2-(4-methylpiperazin-1-yl)pyridine)
• 1187386-40-8(5-Bromo-2-piperazinopyridine Hydrochloride)
• 1254514-23-2(6-Bromo-1-(piperazin-1-yl)isoquinoline)