• 1. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 2. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
  Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
• 3. An approach to biodegradable star polymeric architectures using disulfide coupling?
  Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584
• 4. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 5. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives 2-halopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines 2-halopyridines

Comprehensive Analysis of CAS 1055306-54-1 and A-Ethyl-2-Fluoro-3-Pyridinemethanol: Properties, Applications, and Industry Trends

The compound CAS 1055306-54-1, chemically known as A-Ethyl-2-Fluoro-3-Pyridinemethanol, is a fluorinated pyridine derivative gaining significant attention in pharmaceutical and agrochemical research. This heterocyclic molecule features a unique combination of ethyl, fluoro, and hydroxymethyl functional groups, making it a versatile intermediate for synthesizing bioactive compounds. Its molecular structure (C8H10FNO) offers excellent potential for hydrogen bonding and lipophilic interactions, crucial for drug-receptor binding.

Recent studies highlight the growing demand for fluorinated pyridine derivatives in medicinal chemistry, particularly for developing kinase inhibitors and CNS-targeting drugs. The fluoro substitution at the 2-position enhances metabolic stability, while the hydroxymethyl group at the 3-position provides a handle for further derivatization. Researchers are actively exploring its applications in creating novel antiviral agents and anti-inflammatory compounds, aligning with current global health priorities.

From a synthetic chemistry perspective, A-Ethyl-2-Fluoro-3-Pyridinemethanol demonstrates remarkable regioselectivity in nucleophilic substitution reactions. The electron-withdrawing effect of the fluoro group activates adjacent positions for cross-coupling reactions, making it valuable for constructing complex molecular architectures. Process chemists have developed efficient synthetic routes using microwave-assisted synthesis and continuous flow chemistry techniques to improve yield and purity.

The compound's physicochemical properties include a molecular weight of 155.17 g/mol, moderate water solubility (enhanced by the hydroxymethyl group), and optimal logP for blood-brain barrier penetration. These characteristics make it particularly interesting for central nervous system drug discovery programs. Stability studies show excellent resistance to oxidation under standard storage conditions, though protection from moisture is recommended for long-term storage.

In agrochemical applications, derivatives of CAS 1055306-54-1 have shown promise as plant growth regulators and pest control agents. The fluorine atom improves bioavailability in plant systems while the pyridine core offers structural diversity for targeting specific enzymes in pathogens. Recent patent literature reveals innovative formulations combining this scaffold with biodegradable adjuvants for sustainable agriculture solutions.

Analytical characterization of A-Ethyl-2-Fluoro-3-Pyridinemethanol typically involves HPLC with UV detection (λmax ≈ 265 nm), GC-MS for purity assessment, and comprehensive NMR profiling (1H, 13C, 1?F). The fluorine NMR signal appears as a characteristic doublet due to coupling with adjacent protons, serving as a valuable fingerprint for quality control. Advanced techniques like LC-HRMS and X-ray crystallography have been employed to study its conformational properties.

The commercial availability of CAS 1055306-54-1 has expanded significantly, with suppliers offering various packaging options from milligram to kilogram quantities. Current market trends indicate growing interest from contract research organizations and academic laboratories engaged in fragment-based drug discovery. Pricing remains competitive due to optimized manufacturing processes employing green chemistry principles and catalytic fluorination methods.

Safety evaluations classify this compound as requiring standard laboratory precautions, with no extraordinary hazards reported. Proper handling includes using personal protective equipment and working in well-ventilated areas. Environmental fate studies demonstrate moderate biodegradability, prompting recommendations for responsible waste management practices in industrial settings.

Future research directions for A-Ethyl-2-Fluoro-3-Pyridinemethanol include exploration in proteolysis targeting chimeras (PROTACs) and covalent inhibitor design. The scaffold's ability to serve as a hydrogen bond donor/acceptor makes it particularly valuable for protein-protein interaction modulation. Computational chemistry studies using AI-assisted molecular docking predict several promising biological targets worth experimental validation.

For researchers sourcing this compound, key considerations include supplier reliability, batch-to-batch consistency, and availability of comprehensive analytical data. Many manufacturers now provide certificates of analysis with detailed impurity profiles and stability-indicating methods. The development of custom synthesis services allows for structural modifications to meet specific research requirements.

In conclusion, CAS 1055306-54-1 represents an important building block in modern organic synthesis, with applications spanning multiple industries. Its balanced physicochemical properties and synthetic versatility position it as a valuable tool for researchers developing next-generation therapeutics and agrochemicals. As the scientific community continues to explore fluorinated heterocycles, A-Ethyl-2-Fluoro-3-Pyridinemethanol will likely remain a compound of significant interest in both academic and industrial settings.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)