• 1. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 4. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 5. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinones
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Hydropyridines Pyridinones

Comprehensive Overview of 5-(Trifluoromethoxy)-1H-pyridin-2-one (CAS No. 1052722-33-4): Properties, Applications, and Industry Insights

5-(Trifluoromethoxy)-1H-pyridin-2-one (CAS No. 1052722-33-4) is a fluorinated heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural and electronic properties. The presence of the trifluoromethoxy group (-OCF₃) enhances the molecule's lipophilicity and metabolic stability, making it a valuable scaffold for drug discovery. Researchers frequently search for "5-(trifluoromethoxy)-1H-pyridin-2-one synthesis" or "CAS 1052722-33-4 applications," reflecting its growing relevance in medicinal chemistry.

The compound's pyridin-2-one core is a privileged structure in bioactive molecules, often associated with anti-inflammatory, antiviral, and kinase inhibitory activities. Recent studies highlight its potential in targeting neurodegenerative diseases and oncology, aligning with trending searches like "fluorinated compounds in CNS drugs" and "trifluoromethoxy derivatives for cancer therapy." Its hydrogen-bonding capacity and electron-withdrawing effects make it a versatile building block for rational drug design.

From an industrial perspective, CAS 1052722-33-4 is often explored in "green chemistry approaches" due to increasing regulatory demands for sustainable synthesis. Patent analyses reveal its incorporation in crop protection agents, addressing global concerns about food security and pesticide resistance. The compound's halogenated motif also attracts interest in materials science, particularly for OLEDs and liquid crystals, where its thermal stability and electronic properties are advantageous.

Analytical characterization of 5-(trifluoromethoxy)-1H-pyridin-2-one typically involves NMR (notably ¹⁹F-NMR), HPLC-MS, and X-ray crystallography, with researchers frequently querying "spectral data for CAS 1052722-33-4." Computational studies using DFT calculations predict its reactivity patterns, supporting the optimization of synthetic routes. The compound's logP and pKa values are critical parameters for pharmacokinetic modeling, as noted in ADMET-focused publications.

Emerging applications include its use as a proteolysis-targeting chimera (PROTAC) linker component, tapping into the booming targeted protein degradation field. This connects with high-traffic search terms like "fluorinated linkers in bifunctional molecules." Safety evaluations confirm its compatibility with REACH compliance, though proper handling protocols are essential given its fluorine content.

Market trends indicate rising demand for 1052722-33-4 in contract research organizations, driven by pharmaceutical outsourcing. Suppliers emphasize cGMP-grade availability and custom synthesis options, responding to queries such as "bulk suppliers of trifluoromethoxy pyridinones." The compound's patent landscape shows strategic filings in US, EP, and CN jurisdictions, reflecting global R&D interest.

In summary, 5-(trifluoromethoxy)-1H-pyridin-2-one exemplifies how fluorine chemistry enables modern molecular innovation. Its dual utility in life sciences and advanced materials ensures continued research momentum, with interdisciplinary collaborations unlocking novel applications. The compound's trajectory mirrors broader shifts toward precision therapeutics and sustainable chemical solutions.

• 130318-75-1(5-(difluoromethoxy)-1,2-dihydropyridin-2-one)
• 1804772-62-0(2-(Aminomethyl)-6-hydroxy-3-methoxy-4-(trifluoromethoxy)pyridine)
• 1804316-06-0(6-Hydroxy-3-methoxy-2-methyl-4-(trifluoromethoxy)pyridine)
• 1806760-81-5(5-(Trifluoromethoxy)-2,3,4-trihydroxypyridine)
• 95907-07-6(2-Pyridinol, 5-methoxy-)
• 1806732-00-2(6-Hydroxy-4-methoxy-2-methyl-3-(trifluoromethoxy)pyridine)
• 1361737-94-1(4-(trifluoromethoxy)pyridin-2-ol)
• 1361904-51-9(2-Cyano-6-hydroxy-3-(trifluoromethoxy)pyridine)
• 110860-88-3(2(1H)-Pyridinone, 5-(1,1,2,2-tetrafluoroethoxy)-)
• 61941-79-5(5-methoxypyridin-2-ol)