Pyridinones
Pyridinones are a class of organic compounds characterized by the presence of a pyridine ring with one or more carbonyl groups attached. These molecules exhibit diverse structural and functional properties, making them valuable in various applications across pharmaceuticals, agrochemicals, and materials science.
Structurally, pyridinone derivatives often contain a six-membered heterocyclic ring with an imidazole-like nitrogen atom, which contributes to their unique reactivity and physicochemical properties. The carbonyl group can be positioned at different positions on the pyridine ring, leading to various functional groups such as ketones, esters, or amides.
In pharmaceuticals, pyridinones are used in drugs targeting inflammation, pain relief, and other therapeutic areas due to their anti-inflammatory and analgesic properties. For example, they can inhibit COX enzymes involved in prostaglandin synthesis. In agrochemicals, these compounds may act as fungicides or insecticides by disrupting essential biological processes of pests.
The diverse structural nature of pyridinones allows for the design of molecules with specific functional groups and properties tailored to meet the needs of different applications. Their synthesis can be achieved through various methods including condensation reactions, amidation, and esterification, offering flexibility in their preparation.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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2(1H)-Pyridinone, 3,6-dimethyl- | 53428-02-7 | C7H9NO |
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2(1H)-Pyridinone, 3-iodo-4-methoxy-1-methyl- | 571168-90-6 | C7H8INO2 |
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4-(propan-2-yl)pyridin-2-ol | 408335-38-6 | C8H11NO |
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2(1H)-Pyridinone,1-hydroxy-5-methoxy-6-methyl- | 72731-33-0 | C7H9NO3 |
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2(1H)-Pyridinone,3-fluoro-4-methyl- | 34610-81-6 | C6H6FNO |
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5-Bromo-2,3-dihydroxypyridine | 34206-49-0 | C5H4BrNO2 |
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3-(Hydroxymethyl)-6-methylpyridin-2-ol | 374706-74-8 | C7H9NO2 |
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2(1H)-Pyridinone, 1-methyl-5-pyrazinyl- | 89996-13-4 | C10H9N3O |
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Pyridinetriol, methyl- | 95508-57-9 | C6H7NO3 |
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3-(2-Oxopyridin-1(2H)-yl)propanoic acid | 68634-48-0 | C8H9NO3 |
Related Literature
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Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
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Yang Chen,Di Zhou,Zheyi Meng,Jin Zhai Chem. Commun., 2016,52, 10020-10023
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Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
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Sandip Gangadhar Balwe,Yeon Tae Jeong Org. Biomol. Chem., 2018,16, 1287-1296
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