• 1. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
• 2. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 3. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 4. Fe3O4 nanosphere@microporous organic networks: enhanced anode performances in lithium ion batteries through carbonization?
  Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
• 5. Exciting clusters, what does off-resonance actually mean??
  Goonay Yousefalizadeh,Shideh Ahmadi,Nicholas J. Mosey,Kevin G. Stamplecoskie Nanoscale, 2021,13, 242-252

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives
• Other Chemical Reagents Derivatization Reagents
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Comprehensive Overview of 2-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (CAS No. 1052686-67-5)

2-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (CAS No. 1052686-67-5) is a highly specialized boron-containing heterocyclic compound that has garnered significant attention in pharmaceutical and materials science research. This compound, often referred to as a pyrimidine boronic ester, is a key intermediate in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern organic synthesis. Its unique structure, featuring a tetramethyl-1,3,2-dioxaborolane moiety, enhances stability and reactivity, making it invaluable for constructing complex molecular architectures.

The growing demand for boron-based compounds in drug discovery, particularly for kinase inhibitors and proteolysis-targeting chimeras (PROTACs), has propelled interest in CAS No. 1052686-67-5. Researchers are increasingly exploring its utility in covalent drug design, where boronic acids and esters play a pivotal role due to their reversible binding with biological targets. This aligns with current trends in precision medicine and targeted therapy, addressing unmet medical needs in oncology and inflammatory diseases.

From a synthetic chemistry perspective, 2-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine exemplifies the convergence of scalability and functional group tolerance. Its air-stable nature simplifies handling compared to traditional boronic acids, while the methyl-substituted pyrimidine core offers versatility for further derivatization. These properties are critical for industrial applications, where process optimization and green chemistry principles dominate discussions.

In materials science, this compound contributes to advancements in organic electronics and photovoltaic materials. The dioxaborolane group facilitates π-conjugation extension, a sought-after feature in OLED emitters and organic semiconductors. With the global push toward sustainable energy solutions, researchers are investigating its potential in perovskite solar cells and flexible displays, answering frequent search queries about "next-generation electronic materials."

Analytical characterization of CAS No. 1052686-67-5 typically involves NMR spectroscopy (particularly ¹¹B and ¹³C NMR) and high-resolution mass spectrometry, topics frequently searched by synthetic chemists. The compound's crystalline form and solubility profile (favorable in THF and DMSO) are well-documented, addressing common experimental concerns. Recent publications highlight its use in automated synthesis platforms, reflecting the pharmaceutical industry's shift toward AI-driven molecular design.

Regulatory and safety profiles of this compound adhere to standard laboratory chemical protocols, with particular emphasis on handling moisture-sensitive reagents—a frequently searched topic among junior researchers. Its non-classified status under major chemical inventories makes it accessible for global research collaborations, though proper risk assessment remains essential, as with all synthetic intermediates.

The commercial availability of 2-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine through specialized fine chemical suppliers has increased significantly, with purity grades ranging from 95% to 99% to meet diverse research needs. This availability supports its growing application in high-throughput screening and combinatorial chemistry, areas of intense interest in both academic and industrial settings.

• 321724-19-0(5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine)
• 1235450-87-9(2-ethyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine)
• 1631981-66-2(2-[5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl]acetonitrile)
• 2058051-01-5(5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-ylmethanol)
• 1820679-54-6(2-Isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine)
• 1795453-09-6(2-cyclobutyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine)
• 1025708-31-9(2-Cyanopyrimidine-5-boronic acid pinacol ester)
• 1375301-91-9(2-cyclopropyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine)
• 1402166-11-3(2-cyclohexyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine)
• 1476076-45-5(4,6-dideuterio-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine)