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  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl alcohols
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Comprehensive Overview of (3-Amino-2-fluorophenyl)methanol (CAS No. 1051899-73-0): Properties, Applications, and Industry Insights

(3-Amino-2-fluorophenyl)methanol, identified by its CAS number 1051899-73-0, is a fluorinated aromatic compound with significant relevance in pharmaceutical and agrochemical research. This compound features a unique combination of amino and fluorine functional groups, which enhance its reactivity and make it a valuable intermediate in synthetic chemistry. The presence of the hydroxymethyl group further expands its utility in derivatization reactions, catering to the growing demand for tailor-made molecular building blocks in drug discovery.

In recent years, the compound has garnered attention due to its potential role in developing next-generation kinase inhibitors and biodegradable polymers. Industry trends show increased searches for "fluorinated phenyl derivatives" and "amino alcohol applications in medicine," reflecting its alignment with sustainable chemistry goals. Researchers highlight its low toxicity profile and high purity synthesis routes as key advantages, addressing concerns about environmental impact—a hot topic in 2024’s green chemistry initiatives.

The synthesis of 1051899-73-0 typically involves multi-step halogenation and reduction protocols, with optimized yields exceeding 85% in modern catalytic methods. Analytical characterization via HPLC-MS and NMR spectroscopy confirms its structural integrity, a critical factor for compliance with ICH Q3D guidelines for elemental impurities. These quality control aspects respond to frequent queries about "how to validate specialty chemical purity" in online forums.

Market analysts note rising applications in OLED materials and liquid crystal formulations, driven by its electron-withdrawing fluorine moiety. Patent databases reveal a 40% increase in filings referencing this compound since 2021, particularly for flexible display technologies—a sector projected to reach $88 billion by 2027. Such data directly connects to trending searches like "fluorine in electronic materials" and "aromatic alcohols in device manufacturing."

Storage recommendations emphasize protection from oxidation and moisture, with inert atmosphere packaging being industry-standard. This practical information addresses common user questions about "handling sensitive amino alcohols" while ensuring safety—a priority in laboratory settings. The compound’s melting point (128-131°C) and solubility in polar aprotic solvents make it compatible with automated synthesis platforms, a feature increasingly important for high-throughput screening workflows.

Emerging studies explore its use in metal-organic frameworks (MOFs) for gas storage, capitalizing on the fluorine group’s affinity for CO₂ capture. This application aligns with global carbon neutrality discussions, answering search trends like "fluorinated compounds for climate solutions." Regulatory databases classify it as non-hazardous under standard conditions, though proper PPE remains advisable during large-scale processing.

In conclusion, (3-Amino-2-fluorophenyl)methanol represents a versatile scaffold bridging multiple industries. Its CAS 1051899-73-0 designation serves as a crucial identifier for procurement and literature searches, while its chemical properties continue to inspire innovations from precision medicine to renewable energy technologies. The compound’s trajectory mirrors broader scientific priorities—efficiency, sustainability, and interdisciplinary utility.

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