• 1. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 2. An integrated microfluidic 3D tumor system for parallel and high-throughput chemotherapy evaluation?
  Dan Liu,Rui Hu,Zhongchao Huang,Meilin Sun,Kai Han Analyst, 2020,145, 6447-6455
• 3. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 4. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 5. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
  Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Triazoles

Methyl 2-Methyl-1,2,3-Triazole-4-Carboxylate: A Comprehensive Overview

Methyl 2-Methyl-1,2,3-triazole-4-carboxylate (CAS No. 105020-39-1) is a versatile organic compound that has garnered significant attention in the fields of chemistry and materials science. This compound is characterized by its unique structure, which combines a methyl ester group with a substituted triazole ring. The triazole moiety, in particular, has been extensively studied for its potential applications in various industries. This article delves into the properties, synthesis methods, and recent advancements in the utilization of this compound.

The molecular structure of Methyl 2-Methyl-1,2,3-triazole-4-carboxylate is notable for its triazole ring, a heterocyclic aromatic compound with three nitrogen atoms. The presence of the methyl group at the 2-position of the triazole ring introduces steric effects that can influence the compound's reactivity and stability. Additionally, the ester group at the 4-position plays a crucial role in determining its solubility and compatibility with various solvents. These structural features make it a valuable building block in organic synthesis.

Recent studies have highlighted the synthesis methods for Methyl 2-Methyl-1,2,3-triazole-4-carboxylate as a key area of research. Traditional approaches often involve multi-step reactions, including nucleophilic substitutions and cyclizations. However, advancements in catalytic chemistry have enabled more efficient and environmentally friendly production methods. For instance, researchers have explored the use of transition metal catalysts to facilitate the formation of the triazole ring under mild conditions. These innovations not only enhance yield but also reduce the environmental footprint associated with large-scale production.

The applications of Methyl 2-Methyl-1,2,3-triazole-4-carboxylate are diverse and expanding rapidly. In pharmaceuticals, this compound serves as an intermediate in the synthesis of bioactive molecules targeting various therapeutic areas such as oncology and infectious diseases. Its ability to act as a linker in drug delivery systems has further enhanced its utility in targeted therapies. In materials science, it has been employed as a precursor for advanced polymers and coatings due to its excellent thermal stability and mechanical properties.

One of the most promising areas of research involves the use of Methyl 2-Methyl-1,2,3-triazole-4-carboxylate in click chemistry reactions. Click chemistry is a rapidly growing field that focuses on creating robust chemical bonds under mild conditions. The triazole group's ability to participate in [1+2] cycloadditions with azides or alkynes has made it an invaluable tool for constructing complex molecules efficiently. Recent studies have demonstrated its application in synthesizing nanomaterials such as metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), which hold potential for gas storage and catalysis.

In addition to its chemical applications, Methyl 2-Methyl-1,2,3-triazole-4-carboxylate has shown promise in biotechnology. Its compatibility with biological systems makes it an attractive candidate for use in enzyme immobilization and biosensor development. Researchers have explored its ability to form stable conjugates with proteins and nucleic acids without compromising their functionality. This property opens new avenues for diagnostic tools and therapeutic agents.

From an environmental perspective, understanding the degradation pathways of Methyl 2-Methyl-1,2,3-triazole-4-carboxylate is critical for assessing its ecological impact. Studies have shown that under aerobic conditions, this compound undergoes hydrolysis to form carboxylic acids and other byproducts that are less harmful to aquatic life. Regulatory agencies are increasingly focusing on ensuring that industrial processes involving this compound adhere to strict environmental guidelines to minimize pollution risks.

In conclusion,Methyl 2-Methyl-1,2,3-triazole-4-carboxylate (CAS No. 105020-39-1) stands out as a multifaceted compound with wide-ranging applications across various scientific disciplines. Its unique structure enables it to serve as a versatile building block in organic synthesis while offering innovative solutions in materials science and biotechnology. As research continues to uncover new potential uses for this compound,the demand for sustainable production methods will remain a focal point for future advancements.

• 707-94-8(4,5-dimethyl 1H-1,2,3-triazole-4,5-dicarboxylate)
• 60419-70-7(Methyl 5-methyl-1H-1,2,3-triazole-4-carboxylate)
• 4967-77-5(Methyl 1H-1,2,3-triazole-4-carboxylate)
• 40594-98-7(1H-1,2,3-Triazole-5-carboxylic Acid Ethyl Ester)
• 69457-70-1(2H-1,2,3-Triazole-4-carboxylicacid, 2-ethenyl-, methyl ester)
• 215868-68-1(methyl 2-ethyl-2H-1,2,3-triazole-4-carboxylate)
• 501368-69-0(2H-1,2,3-Triazole-4,5-dicarboxylic acid, 2-methyl-, dimethyl ester)
• 877309-59-6(Methyl 2H-1,2,3-triazole-4-carboxylate)
• 509953-41-7
• 497855-39-7(2H-1,2,3-Triazole-4-carboxylicacid,2-propyl-,methylester(9CI))